Picks of the Day May 8, 2010


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May 22, 2010 - Destination brain - Inhaled pollutants may inflame more than the lungs - Science News

* May 8, 2010 - Government looking to settle hepatitis B needle lawsuits - Kyodo News via The Japan Times

* May 8, 2010 - Three in four teenagers 'unprotected against Meningitis C' - Three in four teenagers could be unprotected against Meningitis C because the effects of a vaccine against the deadly infection have worn off, according to a new study. - The Telegraph, UK - "The findings have led experts to call for secondary schoolchildren to be given an extra 'booster' jab."

* May 8, 2010 - Meningitis C vaccine 'wears off in early teens' - Three-quarters of children vaccinated against meningitis C lose their protection against the disease by their early teens, research suggests. - BBC - "Professor Pollard said: 'This study is just the latest to show that the personal protection given by meningitis C vaccines in early childhood doesn't last forever and several countries have now responded to these findings by introducing teenage boosters, before protection fails in the population.'"

* May 8, 2010 - Shoppers warned of measles danger - Infected child visited two malls - Calgary Herald - "People shopping at two locations Monday -- the Huntington Superstore in northwest Calgary between 12:45 and 3 p.m. and CrossIron Mills shopping mall in Balzac between 1:45 and 7 p.m. -- are being urged to monitor for symptoms of the measles."

* May 8, 2010 - Docs urge vaccination despite flu season end - The Journal Gazette

* May 8, 2010 - FDA Wants To Control Everything Your Family Eats - NewsWithViews.com

* May 8, 2010 - Tylenol linked to autism - Foodconsumer.org

* May 7, 2010 - Panel Tells FDA to Keep Rotavirus Vaccines Available - MedPage Today - "Members of an FDA advisory panel agreed that the two approved rotavirus vaccines -- Merck's RotaTeq and GlaxoSmithKline's Rotarix -- should continue to be used, despite known contamination with a pig virus. ... In both cases, PCV was detected using a new and more sensitive test than was previously used, and the panel warned that more contaminants will likely be found as labs start to implement advance detection methods to test vaccines for viruses and other contaminants. 'There are some very difficult times ahead,' warned panel chairman Jack Stapleton, MD, director of infectious diseases at the University of Iowa Hospital Clinic."

* May 7, 2010 - Benefits trump risks of rotavirus vaccine-US panel - The benefits of rotavirus vaccines from GlaxoSmithKline Plc (GSK.L) and Merck & Co Inc (MRK.N) outweigh any risk from recently discovered contamination with a pig virus, members of a U.S. advisory panel said on Friday. - Reuters - " Any risks "are at best theoretical," said Dr. Melinda Wharton, a panelist and deputy director of the Center for Disease Control and Prevention's National Center for Immunization and Respiratory Diseases. 'Based on where we are with current knowledge, to me the known benefits clearly outweigh the risks,' she said."

* May 7, 2010 - Porcine circovirus DNA found in RotaTeq - Virology Blog - "The source of porcine circovirus type 1 DNA in both Rotarix and RotaTeq is likely to be trypsin used during propagation of the cell cultures necessary for vaccine production. The enzyme is produced from porcine pancreas."

* May 7, 2010 - GSK Statement on FDA Advisory Committee Meeting on Rotavirus Vaccines - press release - GlaxoSmithKline via PRNewswire-FirstCall

* May 7, 2010 - Bhutan launches national vaccination programme on Merck's cervical cancer product - Pharmabiz.com

* May 7, 2010 - Optimal Pandemic Influenza Vaccine Allocation Strategies for the Canadian Population - Elites TV.com

* May 7, 2010 - Vaccines against whooping cough - mysuncoast.com

* May 7, 2010 - Ageing and immunity: Addressing immune senescence to ensure healthy ageing - journal article (Vaccine)

* May 7, 2010 - Balancing safety and immunogenicity in live-attenuated mycobacterial vaccines for use in humans at risk for HIV: Response to Misleading comments in Ranganathan et al. “Recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8+ T cell responses against human immunodeficiency virus type 1 Env and M. tuberculosis in neonatal mice” - journal article (Vaccine)

* May 7, 2010 - Phenotypic and genotypic characteristics of Japanese encephalitis attenuated live vaccine virus SA14-14-2 and their stabilities - journal article (Vaccine)

* May 7, 2010 - Immune response induced by a linear DNA vector: Influence of dose, formulation and route of injection - journal article (Vaccine)

* May 7, 2010 - A dynamic model of pneumococcal infection in the United States: Implications for prevention through vaccination - journal article (Vaccine)

* May 7, 2010 - Scalable production of influenza virus in HEK-293 cells for efficient vaccine manufacturing - journal article (Vaccine)

* May 7, 2010 - A novel mitogen fusion protein against CD40+ cells with potent vaccine adjuvant properties - journal article (Vaccine)

* May 7, 2010 - Reactogenicity and immunogenicity of live attenuated Salmonella enterica serovar Paratyphi A enteric fever vaccine candidates - journal article (Vaccine)

* May 7, 2010 - A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus - journal article (Vaccine)

* May 7, 2010 - Prescription Drug Could Boost Effects of Vaccines for HIV and Other Diseases - A prescription drug already approved to treat genital warts and skin cancer may have a new use in boosting the effectiveness of future vaccines for bacterial and viral diseases, such as hepatitis C and HIV (the AIDS virus). These findings appear in ACS' Molecular Pharmaceutics, a bi-monthly journal. - American Chemical Society, via EurekAlert! via ScienceDaily

* May 7, 2010 - Health care providers push for H1N1 immunizations - The Sun

* May 7, 2010 - No Link Between Childhood Infections, Autism - Study of 1.4 million Danish children finds no connection - Archives of Pediatrics & Adolescent Medicine via HealthDay News via Business Week

* May 7, 2010 - FDA's Risk Aversion Is Endangering Children - The agency has sown confusion by asking physicians to stop administering a vaccine that even they admit is safe. - opinion - Forbes

* May 7, 2010 - Merck Vaccine Recalled in Hong Kong, to Remain in Use in U.S. - FairWarning

* May 7, 2010 - Software glitch hampers child flu vaccine records - Medical Observer - "Professor Terry Nolan, the chair of the Australian Technical Advisory Group on Immunisation, said while WA GPs last year had been required to provide a manual line listing of paediatric flu vaccinations, this year the State Government decided to rely on the ACIR. However, a software problem with at least one major product had prevented GPs from uploading the data, he said, arguing it was vital to obtain baseline numbers of vaccinated children to accurately determine the rate of adverse events."

* May 7, 2010 - U.S. lawmaker seeks details on Tylenol recall - Another U.S. lawmaker asked regulators on Friday for information about Johnson & Johnson's recall of Children's Tylenol and other over-the-counter pediatric medicines. - Reuters

* May 7, 2010 - Who gets $15 billion for disease prevention? - Public health officials, nonprofits tout competing strategies for funds - MSNBC

* May 7, 2010 - 1 Year Later, H1N1 Risk 'Very Minimal' - Current H1N1 Strain Will Be Part Of Fall's Seasonal Flu Vaccine - KETV Omaha - "While the reduced threat is welcome news, it also means that Douglas County had a lot of wasted vaccine. More than 34,000 doses have already expired and 28,000 more will have to be thrown away by the end of the month."

* May 7, 2010 - Mercy Flights administering H1N1 vaccines during housecalls (includes video) - KDRV.com

* May 7, 2010 - Study: Adjuvanted H1N1 vaccine was very effective - CIDRAP News

* May 7, 2010 - FDA Accepts Novartis Vaccines' sBLA to Expand Indication of Menveo(R) to Children 2-10 Years of Age - Menveo vaccine was licensed in February 2010 for use in people 11-55 years of age to help protect against four vaccine-preventable meningococcal serogroups(1) - FDA also accepted separate sBLA including data which describes persistence of meningococcal antibodies in adolescents 22 months postvaccination - Novartis plans to seek licensure of Menveo for infants in 2011 - press release - Novartis Vaccines via Marketwire via MarketWatch

* May 7, 2010 - Mystery Disease Linked to Missing Israeli Scientist - truthout - "Several researchers in California also note that the Cryptococcus gatti fungus has been researched for decades, extending back to the 1950's, at the US Army's biological warfare center, Fort Detrick, in Frederick, Maryland. One microbiologist at the University of California at Los Angeles recounted that the fungus was first brought to the attention of Fort Detrick researchers by British scientists experimenting with the bark of eucalyptus trees from Australia."

* May 7, 2010 - Case of measles confirmed in Calgary - Those exposed should monitor symptoms - Calgary Herald - "If the potentially exposed people haven’t already had measles or been vaccinated, they could be at risk for developing the disease, said Dr. Judy MacDonald, AHS medical officer of health for Calgary. ... A child under the age of five is recovering at home after contracting the disease, MacDonald said. It’s not yet certain where the child was first exposed to measles, although health officials are looking into whether a relative who had similar symptoms may have had the disease. The child had received the first dose of vaccination but wasn’t yet old enough to receive the second dose, MacDonald said."

* May 7, 2010 - Teva, Baxter ordered to pay $500 mln in Hep C case * Teva ordered to pay $356 mln; Baxter to pay $144 mln * Lawsuit stems from largest Hepatitis C outbreak * Lawyer says more cases to come - Reuters

* May 7, 2010 - HIV Vaccine Secret Found in 'Elite Controllers' - Genetic Mutation Allows Some People to Never Get AIDS - Nature via WebMD

* May 6, 2010 - Optimal Pandemic Influenza Vaccine Allocation Strategies for the Canadian Population - journal article (PLoS One)

* May 6, 2010 - Parents with more education less likely to let their daughters get HPV shots - The Canadian Press via Fort Frances Times Online - "Girls from two-parent households were less likely to have been given permission to get the shot. And parents with more education were more likely to have said no. Ogilvie called it “the main surprise” of the study. “This is a flip from our traditional understanding,” she said. But Offit said this has also been spotted by researchers looking into trends in childhood vaccine rates."

* May 6, 2010 - 255 scientists: 'deeply disturbed' by 'political assaults on scientists' - Science behind climate change remains robust, according to researchers. - MongaBay.com

* May 6, 2010 - FDA: Pa. Plant That Made Recalled Children's Medicine Had Dust, Grime (includes video) - WPXI.com Pittsburgh - "A report by the Food and Drug Administration found the McNeil Consumer Healthcare plant in Fort Washington apparently wasn't checking for bacteria, storing materials safely or training employees properly. It said general quality control was nonexistent."

* May 6, 2010 - Low vitamin D common even among southern teens - Pediatrics via Reuters Health

* May 6, 2010 - U.S. Panel Criticized as Overstating Cancer Risks (requires registration) - The New York Times - "A dire government report on cancer risks from chemicals and other hazards in the environment has drawn criticism from the American Cancer Society, which says government experts are overstating their case."

* May 6, 2010 - Study: More parents skip or postpone vaccines - The Mommy Files via San Francisco Chronicle

* May 6, 2010 - Novartis in thicket of H1N1 vaccine cancellations - FiercePharma

* May 3, 2010 - Exposure to bisphenol A may alter hormone levels in men. - Environmental Science and Technology via Environmental Health News

* May 3, 2010 - Studies find remarkably high levels of flame retardants in California's children. - Environmental Research via Environmental Health News

* May 2010 - Antibody Response Patterns to Bordetella pertussis Antigens in Vaccinated (Primed) and Unvaccinated (Unprimed) Young Children with Pertussis - journal article (Clinical and Vaccine Immunology)

* May 2010 - Disruption of antigenic variation is crucial for effective parasite vaccine - journal article (Nature Medicine)

* May 2010 - Vaccine contamination prompts safety review - journal article (Nature Medicine)

* April 28, 2010 - Cellular immunity in children with successful immunoprophylactic treatment for mother-to-child transmission of hepatitis B virus (pdf) - journal article (BMC Infectious Diseases)

* April 20, 2010 - Title: Antibodies against and methods for producing vaccines for respiratory syncytial virus (patent) - MedImmune, LLC (Gaithersburg, MD) via www.pharmcast.com

* April 20, 2010 - Title: Compositions and methods for enhancing the immunogenicity of antigens (patent) - The Trustees of the University of Pennsylvania (Philadelphia, PA) via www.pharmcast.com