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July 24, 2002
INTERNATIONAL IMMUNIZATION NEWS
"Characterization of CHAT and Cox Type 1 Live-Attenuated Poliovirus Vaccine Strains" Journal of Virology (jvi.asm.org) (06/02) Vol. 76, No. 11, P. 5339; Martmn, Javier; Minor, Philip D.
In the 1950s, scientists developed CHAT and Cox type 1 live-attenuated vaccines to prevent polio in humans. An analysis of four isolates from cases of vaccine-associated paralytic poliomyelitis were found to be related to the CHAT vaccine as determined by their genetic and phenotypic properties. Called CHAT-VAPP strain 134, the polio strain is significantly evolved from CHAT, indicating that the vaccine-derived strain has been circulating in the population through replication in the human intestine.
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