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MMR Urabe vaccine (Pluserix & Immravax)
MMR vaccines

On september 14, 1992 two measles vaccines (Pluserix & Immravax) were banned in the UK after it was revealed that children had developed meningitis.  On Sept 16, 1992 the New Zealand government withdrew Pluserix

"In 1990, scientists from the Queen’s Medical Centre Nottingham found some children developed a form of meningitis after receiving it. But despite this the Government went on using it for more than two years.  The Canadian Government, also using the vaccine, immediately switched to a safer version. It was not until September 1992 that the UK Department of Health issued pharmacists with emergency supplies of a safer brand with instructions to withdraw existing batches."--Sunday Express

[Media UK, April 2001 MMR] Jab risk was ignored

1997 Brazil:
OUTBREAK OF ASEPTIC MENINGITIS ASSOCIATED WITH MASS VACCINATION WITH A URABE CONTAINING MMR VACCINE

"When notifications of meningitis (from MMR vaccine) from physicians were included; when the vaccine records of hospital cases of meningitis were included; when cross linkage of vaccine records from laboratory reports (4 laboratories) was performed and included the figure was increased to 1 in 11,000. It should be noted that in the case of one particular laboratory, this was 1 in 4,000. "----- Paul Shattock and Dawn Savery,  Autism Research Unit, University of Sunderland, Sunderland, UK.   The Role of Vaccines in the Causation of Autism and Related Disorders---Paul Shattock and Dawn Savery, Autism Research Unit, University of Sunderland, Sunderland, UK.1997

"Out of the 90 children on that list, 24 received a vaccine called Pluserix-MMR manufactured by SmithKline Beecham. It was withdrawn in the UK on the 14th September 1992 because of "reports of mild transient meningitis."    "Of the children that received Pluserix-MMR on that list, 3 died (1 after meningitis) , 4 had meningitis symptoms, 5 epilepsy, 5 had become autistic, 1 suffered from rheumatoid arthritis, 1 had severe urticaria and 2 had mumps. 6 had their speech affected - forgetting language skills they had acquired, 1 went deaf. 6 from this time suffered from delayed development and 4 were very very disturbed. One of the deaths was from the Guillain-Barré syndrome - where antibodies are produced that attack the body's own cells . 7 or more suffered frequent fits or convulsions, 1 had terrible screaming fits.  Thirteen of the children on that list received Immravax made by the French company, Merieux UK Ltd. This was also withdrawn on the same date and for the same reason as Pluserix-MMR - because of "reports of mild transient meningitis.".   Of the children that received Immravax; 6 became epileptic, 1 nearly died from encephalitis, 3 had meningitis, 1 measles and 1 mumps, 5 had speech and communication problems, 3 became slow developers, 7 had frequent fits and convulsions, 2 went into the kind of terrible screaming fits that are associated with brain trauma."---Jani Roberts http://www.gn.apc.org/inquirer/jabs.html

"The Urabe strain, he writes, was replaced here in 1992 after it was "rarely" associated with "severe headaches".  Actually the Urabe strain was used in the MMR vaccines, Immravax and Pluserix, in this country between 1988 and 1992. Both were hastily withdrawn in 1992 after they were found to cause not "rare" but unusually high rates (more than I in 11,000) of potentially fatal aseptic mumps meningitis— er, a little more than a "severe headache", the Eye would suggest. And Watson should know because his company, then Merieux UK, manufactured the dodgy Immravax. Smith Kline Beecham produced the other.
    And here are two more important "facts" he left out. When those MMR vaccines were licensed here in 1988, an identical vaccine containing the Urabe strain produced by Smith Kline Beecham and called Trivirex had already been withdrawn from Canada because of suspected links to aseptic mumps meningitis. This no doubt would have passed unnoticed by our government scientists responsible for licensing because — as we now know courtesy of the BSE inquiry — the department was then a shambles. But it could not have passed unnoticed by MMR manufacturers.
    Yet as late as 1997 the Smith Kline Beecham Urabe MMR jab was used in a mass vaccination programme in Brazil and caused, yes, an outbreak of aseptic meningitis."---Private Eye

[Media June 2000, MMR--meningitis & death] Mother’s regret over son who still suffers

Meningitis & vaccines

MMR vaccine & aseptic meningitis, Japan 1989-1993

Dourado I, Cunha S, Teixeira MG, Farrington CP, Melo A, Lucena R, Barreto ML.Outbreak of aseptic meningitis associated with mass vaccination with a urabe-containing measles-mumps-rubella vaccine: implications for immunization programs. Am J Epidemiol. 2000 Mar 1;151(5):524-30.
PMID: 10707922
A mass immunization campaign with a Urabe-containing measles-mumps-rubella vaccine was carried out in 1997 in the city of Salvador, northeastern Brazil, with a target population of children aged 1-11 years. There was an outbreak of aseptic meningitis following the mass campaign. Cases of aseptic meningitis were ascertained through data collected from the records of children admitted to the local referral hospital for infectious diseases between March and October of 1997, using previously defined eligibility criteria. Vaccination histories were obtained through home visits or telephone calls. Eighty-seven cases fulfilled the study criteria. Of those, 58 cases were diagnosed after the vaccination campaign. An elevated risk of aseptic meningitis was observed 3 weeks after Brazil's national vaccination day compared with the risk in the prevaccination period (relative risk = 14.3; 95% confidence interval: 7.9, 25.7). This result was confirmed by a case series analysis (relative risk = 30.4; 95% confidence interval: 11.5, 80.8). The estimated risk of aseptic meningitis was 1 in 14,000 doses. This study confirms a link between measles-mumps-rubella vaccination and aseptic meningitis. The authors discuss the implications of this for the organization and planning of mass immunization campaigns.

Autret E, Jonville-Bera AP, Galy-Eyraud C, Hessel L.[Aseptic meningitis after mumps vaccination].Therapie. 1996 Nov-Dec;51(6):681-3. French.PMID: 9164005

The aim of this retrospective study was to evaluate the incidence and the characteristics of spontaneously reported aseptic meningitis (AM) in France following mumps vaccination with monovalent or multivalent vaccines containing the Urabe strain. Fifty-four cases of AM were reported to the regional drug surveillance centres or to the manufacturer from the time each vaccine was launched up until June 1992. Twenty cases were associated with the time off administration of a monovalent mumps vaccine and 34 with a trivalent measles, mumps and rubella vaccine (MMR). A mumps virus was isolated in four cases in the cerebrospinal fluid and an Urabe-like strain was characterised twice by polymerase chain reaction (PCR). A probable mumps origin was assumed in 17 other cases where the patients presented with other clinical or biological signs of mumps infection. The clinical outcome of AM was always favourable. The global incidence of mumps vaccine-associated AM was 0.82/100,000 doses, which is significantly lower than the incidence in the unvaccinated population. Even considering that the actual incidence of AM is much higher when assessed by active surveillance studies, the risk/benefit ratio of mumps vaccine remains in favour of vaccination. The incidence of mumps vaccines containing Jeryl Lynn (ROR Vax et Imu ORR) associated with AM needs to be evaluated.

Kimura M, Kuno-Sakai H, Yamazaki S, Yamada A, Hishiyama M, Kamiya H, Ueda K, Murase T, Hirayama M, Oya A, Nozaki S, Murata R.Adverse events associated with MMR vaccines in Japan. Acta Paediatr Jpn. 1996 Jun;38(3):205-11.PMID: 8741307
The largest nationwide active surveillance of four Measles-Mumps-Rubella (MMR) vaccines was conducted in Japan. A total of 1255 pediatricians actively participated in the study, which comprised 8.6% of all members of the Japanese Pediatric Society. The total number of registered recipients of MMR vaccines was 38 203. They were arbitrarily given one of the MMR vaccines produced by three makers (Takeda, Osaka city, Kitasato Minato-ku. Tokyo and Biken Suita city, Japan) or the standard MMR vaccine made of designated strains (Kitasato's measles-AIK-C, Biken's mumps-Urabe Am9 and Takeda's rubella-To336) produced by Takeda, Kitasato and Biken and were observed for 35 days. The rates of virologically confirmed aseptic meningitis per 10,000 recipients were 16.6, 11.6, 3.2 and 0 for the standard MMR, Takeda MMR, Kitasato MMR and Biken MMR vaccines, respectively. The incidence of convulsions between 15 and 35 days was the highest with the standard MMR vaccine and the incidence of fever associated with vomiting occurring between 15 and 35 days (symptoms relevant to aseptic meningitis) were also the highest with the standard MMR vaccine. The incidence of parotid swelling was the lowest with Takeda MMR vaccine. This surveillance revealed that incidences of aseptic meningitis after administration of the standard MMR vaccine and of Biken MMR vaccine were different. This posed questions about the manufacturing consistency of the Urabe Am9 mumps virus vaccines. On the other hand, the National Institute of Health found that the biological characteristics of the Urabe Am9 mumps virus contained in the standard MMR vaccine and in the Biken MMR vaccine were different. The Biken Company reported that the mumps vaccine in the standard MMR vaccine was a mixture of two Urabe Am9 mumps vaccine bulks; one identical to that contained in the Biken MMR vaccine and the other produced by a different manufacturing process. PMID: 8741307

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