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Pediatric Neurology
Volume 28, Issue 4 , April 2003, Pages 292-294


 

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doi:10.1016/S0887-8994(02)00627-6    How to cite or link using doi (opens new window) Cite or link using doi  
Copyright © 2003 Elsevier Science Inc. All rights reserved.

Original article

 

Elevated levels of measles antibodies in children with autism

 

Vijendra K. Singh PhD*, Corresponding Author Contact Information and Ryan L. Jensen BS

* Department of Biology and Biotechnology Center, Utah State University, Logan, Utah, USA

Received 23 July 2002;  accepted 28 October 2002. ; Available online 27 February 2003.


 

Abstract

Virus-induced autoimmunity may play a causal role in autism. To examine the etiologic link of viruses in this brain disorder, we conducted a serologic study of measles virus, mumps virus, and rubella virus. Viral antibodies were measured by enzyme-linked immunosorbent assay in the serum of autistic children, normal children, and siblings of autistic children. The level of measles antibody, but not mumps or rubella antibodies, was significantly higher in autistic children as compared with normal children (P = 0.003) or siblings of autistic children (P less-than or equal to 0.0001). Furthermore, immunoblotting of measles vaccine virus revealed that the antibody was directed against a protein of approximately 74 kd molecular weight. The antibody to this antigen was found in 83% of autistic children but not in normal children or siblings of autistic children. Thus autistic children have a hyperimmune response to measles virus, which in the absence of a wild type of measles infection might be a sign of an abnormal immune reaction to the vaccine strain or virus reactivation.

Author Keywords: Autism; measles virus; vaccine; viral antibodies; mumps virus; rubella virus


 

Corresponding Author Contact InformationCorresponding author. Communications should be addressed to: Dr. Singh; Biotechnology Center; Utah State University; 4700 Old Main Hill; , Logan, Utah, 84322, , USA.



 
 
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Pediatric Neurology
Volume 28, Issue 4 , April 2003 , Pages 292-294



 

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