* #7 #3 and #6 (7 records)
#6 #4 or #5 (7071 records)
#5 explode 'Autistic-Disorder' / all subheadings in MIME,MJME (5873 records)
#4 autis* (7071 records)
#3 #1 or #2 (19292 records)
#2 explode 'Mercury-' / all subheadings in MIME,MJME (11235 records)
#1 mercury or thimerosal (19292 records)
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Med Hypotheses 2001 Apr;56(4):462-71 Related Articles, 
Books,
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Autism: a novel form of mercury poisoning.
Bernard S, Enayati A, Redwood L, Roger H, Binstock T.
ARC Research, Cranford, New Jersey 07901, USA.
Autism is a syndrome characterized by impairments in social relatedness and communication, repetitive behaviors, abnormal movements, and sensory dysfunction. Recent epidemiological studies suggest that autism may affect 1 in 150 US children. Exposure to mercury can cause immune, sensory, neurological, motor, and behavioral dysfunctions similar to traits defining or associated with autism, and the similarities extend to neuroanatomy, neurotransmitters, and biochemistry. Thimerosal, a preservative added to many vaccines, has become a major source of mercury in children who, within their first two years, may have received a quantity of mercury that exceeds safety guidelines. A review of medical literature and US government data suggests that: (i) many cases of idiopathic autism are induced by early mercury exposure from thimerosal; (ii) this type of autism represents an unrecognized mercurial syndrome; and (iii) genetic and non-genetic factors establish a predisposition whereby thimerosal's adverse effects occur only in some children. Copyright 2001 Harcourt Publishers Ltd.
Publication Types:- Review
- Review, Academic
http://www.vaccinationnews.com/dailynews/july2001/autismuniquemercpoison.htm - to read the entire aritcle
PMID: 11339848 [PubMed - indexed for MEDLINE]
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West Indian Med J 2001 Mar;50(1):87-9 Related Articles, Books,
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The MMR vaccination and autism: a lay person's contribution.
Hamilton M.
Publication Types:- Letter
PMID: 11398299 [PubMed - indexed for MEDLINE]
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Nature 2001 Jun 21;411(6840):882-4 Related Articles, Books,
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The search for autism's roots.
Wong K.
Publication Types:- News
PMID: 11418823 [PubMed - indexed for MEDLINE]
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Environ Health Perspect 2001 Jul;109(7):A303-4 Related Articles, Books,
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Mercury and autistic gut disease.
McGinnis WR.
Publication Types:- Letter
PMID: 11569621 [PubMed - indexed for MEDLINE]
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Environ Health Perspect 2000 Jun;108 Suppl 3:511-33 Related Articles, Books,
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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Rice D, Barone S Jr.
National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, D.C., USA.
Vulnerable periods during the development of the nervous system are sensitive to environmental insults because they are dependent on the temporal and regional emergence of critical developmental processes (i.e., proliferation, migration, differentiation, synaptogenesis, myelination, and apoptosis). Evidence from numerous sources demonstrates that neural development extends from the embryonic period through adolescence. In general, the sequence of events is comparable among species, although the time scales are considerably different. Developmental exposure of animals or humans to numerous agents (e.g., X-ray irradiation, methylazoxymethanol, ethanol, lead, methyl mercury, or chlorpyrifos) demonstrates that interference with one or more of these developmental processes can lead to developmental neurotoxicity. Different behavioral domains (e.g., sensory, motor, and various cognitive functions) are subserved by different brain areas. Although there are important differences between the rodent and human brain, analogous structures can be identified. Moreover, the ontogeny of specific behaviors can be used to draw inferences regarding the maturation of specific brain structures or neural circuits in rodents and primates, including humans. Furthermore, various clinical disorders in humans (e.g., schizophrenia, dyslexia, epilepsy, and autism) may also be the result of interference with normal ontogeny of developmental processes in the nervous system. Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function. This concern is compounded by the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
Publication Types:- Review
- Review, Tutorial
PMID: 10852851 [PubMed - indexed for MEDLINE]
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J Ment Defic Res 1985 Mar;29 ( Pt 1):15-22 Related Articles, Books,
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Trace element concentrations in hair from autistic children.
Wecker L, Miller SB, Cochran SR, Dugger DL, Johnson WD.
The concentrations of 14 elements were determined in scalp hair samples from control, autistic and autistic-like children. Significant differences were noted between normal males and females for calcium, magnesium and mercury. The autistic population had significantly lower levels of calcium, magnesium, copper, manganese and chromium and higher levels of lithium as compared to sex- and age-matched controls. Children with autistic features (autistic-like), classified as having childhood-onset pervasive disorder, had lower levels of magnesium, cadmium, cobalt and manganese as compared to controls. Discriminant function analysis using the 14 trace elements correctly classified 90.5% of the normal and 100% of the autistic population. Using a stepwise procedure, the five elements with the greatest discriminatory power were calcium, copper, zinc, chromium and lithium. Analysis based on these five trace elements led to the correct classification of 85.7% of the normal and 91.7% of the autistic group. Results indicate that the concentrations of trace elements in hair from normal children differ from patterns observed in both autistic and autistic-like children. Furthermore, evidence suggests that hair analysis may have potential use as a diagnostic tool for autism.
PMID: 4009700 [PubMed - indexed for MEDLINE]
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Psychiatr Enfant 1972;15(2):609-13 Related Articles, Books,
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[Characteristic aspects of child psychiatry in Japan]
[Article in French]
Murata T.
PMID: 4681137 [PubMed - indexed for MEDLINE]