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Egg White Allergy Doesn't Preclude Influenza Vaccination

A DGReview of :"[Immediate adverse reactions after administration of the influenza vaccine to patients with positive CAP-RAST to egg white]"
Arerugi

09/12/2002
By Elda Hauschildt
 

Most patients with positive allergic to egg whites, either after eating the egg or through testing positive on CAP-RAST, can receive influenza vaccinations, Japanese researchers report.

Investigators from Kochi Medical School in Kochi used Sandwich ELISA to measure the content of OVA in influenza vaccine preparations. They found concentrations ranged from 2 nanograms per millilitre to 8 ng/mL.

Thirty six high-risk patients were vaccinated with influenza vaccine. The participants had positive CAP-RAST scores greater than four to egg white and/or had experienced immediate hypersensitivity after eating egg.

Only one participant experienced local swelling after vaccine administration. All of the remaining 35 patients had no serious systemic adverse reactions.

The researchers also examined the incidence of immediate adverse vaccination reaction in 104 patients with positive CAP-RAST to egg white. They compared these results with those of 98 patients with negative CAP-RAST.

They found no significant difference in adverse reactions between the two groups of patients.
Arerugi, 2002; 51: 559-564 "[Immediate adverse reactions after administration of the influenza vaccine to patients with positive CAP-RAST to egg white]"

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