"Effect of Vaccination With Carrier Protein on Response to Meningococcal C Conjugate Vaccines"

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September 16, 2002

 

INTERNATIONAL IMMUNIZATION NEWS

 

"Effect of Vaccination With Carrier Protein on Response to Meningococcal C Conjugate Vaccines" Infection and Immunity Online (iai.asm.org) (09/02/02) Vol. 70, No. 9, P. 4946; Burrage, Moya; Robinson, Andrew; Borrow, Ray

 

A Phase II trial was conducted to see whether an interaction existed between meningococcal C (MCC) vaccines conjugated to tetanus toxoid or a derivative of diphtheria toxin and diphtheria-tetanus vaccines.  While vaccine response was inhibited by prior immunization with a tetanus-containing vaccine, sufficient protection from the pathogen was provided. The MCC vaccine's effectiveness was not affected by diphtheria-containing vaccine.  The enzyme-linked immunosorbent assays of the enzyme-linked vaccines and those that measure high-avidity antibodies to meningococcal C polysaccharide correlated similarly with assays that measure serum bactericidal antibodies.

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