"Effect of Vaccination With Carrier Protein on Response to Meningococcal C Conjugate Vaccines"
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"Effect of Vaccination With Carrier Protein on
Response to Meningococcal C Conjugate Vaccines" Infection and Immunity Online (iai.asm.org)
(09/02/02) Vol. 70, No. 9, P. 4946; Burrage, Moya; Robinson, Andrew; Borrow, Ray
A Phase II trial was conducted to see whether an
interaction existed between meningococcal C (MCC) vaccines conjugated to tetanus
toxoid or a derivative of diphtheria toxin and diphtheria-tetanus vaccines.
While vaccine response was inhibited by prior immunization with a
tetanus-containing vaccine, sufficient protection from the pathogen was
provided. The MCC vaccine's effectiveness was not affected by
diphtheria-containing vaccine. The enzyme-linked immunosorbent assays of the
enzyme-linked vaccines and those that measure high-avidity antibodies to
meningococcal C polysaccharide correlated similarly with assays that measure
serum bactericidal antibodies.
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