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: J Travel Med 2000 Jan;7(1):35-36 |
Reactive arthritis associated with typhoid
vaccination in travelers: report of two cases with negative HLA-B27.
Adachi JA, D'Alessio FR, Ericsson CD.
Department of Medicine, Division of Infectious Diseases, University of Texas
Houston Medical School, Houston, Texas 77030, USA.
As international travel to developing countries increases, more people seek
medical advice concerning food and water-borne diseases, including typhoid
fever. Prevention of typhoid fever in high-risk groups (travelers to endemic
areas, laboratory workers and household contacts of typhoid carriers) should
rely primarily on prevention of exposure. However, immunization is an important
adjunct. The decision to immunize against typhoid fever should be
individualized, taking into account the benefits versus the risk of possible
adverse reactions. Cases of reactive arthritis have been associated with the
heat-phenol inactivated 'whole cell' parenteral vaccine, but to our knowledge
reactive arthritis has not been previously reported with the oral form (Ty21a).
This is a report of HLA-B27 negative reactive arthritis occurring in two
travelers after the administration of oral Ty21a typhoid vaccine.
PMID: 10689239 [PubMed - indexed for MEDLINE]