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Comment in:

·         Rev Rhum Engl Ed. 1998 Oct;65(10):598

Inflammatory joint disease after immunizations. A report of two cases.

Ferrazzi V, Jorgensen C, Sany J.

Immunorheumatology Department, Lapcyronie Hospital, Montpellier, France.

Serious adverse effects of immunizations are uncommon. The hepatitis B vaccine has been implicated in a few dozen cases of extraarticular, systemic, or inflammatory joint disorders. We report two cases in which hepatitis A vaccination (Havrix, Smith Kline Beecham) was followed by a connective tissue disorder or a spondylarthropathy in two healthy males aged 50 and 24 years, respectively. Both patients were HLA B27-negative but carried the HLA DR1 and/or DR4 antigen. The outcome was favorable after treatment with a corticosteroid or a nonsteroidal antiinflammatory agent. The pathophysiology of immunization-related rheumatic disorders may involve circulating immune complexes and/or a mechanism similar to that seen in reactive arthritis, i.e., a genetically-determined susceptibility to the bacterial or viral antigens contained in vaccines.

Publication Types:

·         Review

·         Review of reported cases

PMID: 9178394 [PubMed - indexed for MEDLINE]

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