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: Rev Rhum Engl Ed 1997 Apr;64(4):227-232 |
Comment in:
·
Rev Rhum Engl Ed. 1998 Oct;65(10):598
Inflammatory joint disease after
immunizations. A report of two cases.
Ferrazzi V, Jorgensen C, Sany J.
Immunorheumatology Department, Lapcyronie Hospital, Montpellier, France.
Serious adverse effects of immunizations are uncommon. The hepatitis B vaccine
has been implicated in a few dozen cases of extraarticular, systemic, or
inflammatory joint disorders. We report two cases in which hepatitis A
vaccination (Havrix, Smith Kline Beecham) was followed by a connective tissue
disorder or a spondylarthropathy in two healthy males aged 50 and 24 years,
respectively. Both patients were HLA B27-negative but carried the HLA DR1
and/or DR4 antigen. The outcome was favorable after treatment with a
corticosteroid or a nonsteroidal antiinflammatory agent. The pathophysiology of
immunization-related rheumatic disorders may involve circulating immune
complexes and/or a mechanism similar to that seen in reactive arthritis, i.e.,
a genetically-determined susceptibility to the bacterial or viral antigens
contained in vaccines.
Publication Types:
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Review
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Review of reported cases
PMID: 9178394 [PubMed - indexed for MEDLINE]
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