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Vaccines
expert warns studies are useless
By Lorraine Fraser, Medical Correspondent
(Filed: 27/10/2002)
Most safety studies on childhood vaccines have not been
conducted thoroughly enough to tell whether the jabs cause side effects,
a leading authority on vaccine research has warned.
Dr Thomas Jefferson, who has been funded to investigate
vaccine safety by the European Commission, said that the issue was the
"Cinderella" of public health research and that Government officials had
failed to make it a high priority.
Dr Jefferson is the head of the vaccine division of the
Cochrane Collaboration, an organisation of scientists that aims to make
accurate information about the effects of treatments available worldwide
and promotes high standards in research.
He is also a board member of the European Programme for
Improved Vaccine Safety Surveillance, set up by the commission.
He said: "There is some good research, but it is
overwhelmed by the bad. The public has been let down because the proper
studies have not been done."
His outspoken and unprecedented comments will anger
public health officials in Britain and elsewhere, who fear that any
discussion will undermine parents' confidence in national vaccination
programmes.
Officials at the Department of Health are already
alarmed by the number of parents shunning the triple measles, mumps and
rubella jab (MMR) after claims that it is linked with autism and bowel
disease.
Although Dr Jefferson emphasised that there was no
evidence to suggest that any vaccine now in use was dangerous, he said
that there was a "dearth" of sound studies on the risks and benefits.
As a result, the information available on the safety of
vaccines that are routinely given to babies and toddlers was "simply
inadequate".
Dr Jefferson also disclosed plans for a Europe-wide
electronic register of children's vaccine exposure that would allow
scientists to investigate the risks and benefits of inoculations using
data on thousands of participants. Pilot schemes will start soon in
Sweden and Finland.
"We need such a system urgently," he said. "Governments
are reluctant to accept this but in my view they owe it to future
generations to back this idea."
He was especially concerned, he said, because future
vaccination programmes were likely to involve giving children "five,
six, even seven vaccines all at once".
A vaccine designed to protect children against measles,
mumps, rubella and chickenpox in one shot is already under development.
"For people like me, it is becoming more and more
difficult to tease out what problems may be due to an individual
vaccine," said Dr Jefferson.
"It is almost becoming impossible to do this. We have
to think very carefully about how we will monitor these vaccines.
"We have a responsibility to these children - they are
our future. It is no use having a situation where someone suggests a
possible harm and everyone runs around frantically trying to find bits
of evidence. What is required is good-quality information that has been
systematically collated and assessed."
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