Quantitative neuropathological analysis of Sudden Infant Death Syndrome

Vaccination News Home Page

http://www.blackwell-synergy.com/servlet/useragent?func=synergy&synergyAction=showAbstract&doi=10.1046/j.1365-2214.2002.00001.x

Home > List of Issues > Table of Contents > Abstract

Abstract

Child: Care, Health & Development
Volume 28 Issue s1 Page 3 - September 2002

Quantitative neuropathological analysis of Sudden Infant Death Syndrome

T. Ansari, P. D. Sibbons, A. Parsons and M. L. Rossi*

Abstract

Detailed stereological analyses of specific regions of brains of children who had died from Sudden Infant Death Syndrome (SIDS) was undertaken to determine whether global evidence of an underlying pathology exists, contributing to an increased susceptibility to SIDS. A significant reduction in the total number of neocortical neurones and neurone volume was observed in SIDS normal birth weight (NBW) infants in comparison to controls. A significant reduction in both volume and total neurone number were also noted in the dorsal motor nucleus of the vagus in SIDS NBW group when compared with controls. Anomalies in regions of the brain involved with cardiorespiratory control (brainstem) and arousal (brainstem and neocortex) may play a crucial role in the chain of events resulting in a SIDS event.

QuickSearch in:

for

Authors:

T. Ansari

P. D. Sibbons

A. Parsons

M. L. Rossi

Keywords

stereology

brainstem nuclei

neocortex

corpus callosum

sudden infant death syndrome

Affiliations

Department of Surgical Research, Northwick Park Institute for Medical Research, Northwick Park Hospital, Harrow, and*Department of Neuropathology, Walton Centre for Neurology and Neurosurgery, Fazakerely Hospital, Liverpool, UK

Correspondence

Tahera Ansari, Department of Surgical Research, Northwick Park Institute for Medical Research, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK E-mail: T.I.Ansari@ic.ac.uk

To cite this article
Ansari, T., Sibbons, P. D., Parsons, A. & Rossi, M. L.
Quantitative neuropathological analysis of Sudden Infant Death Syndrome.
Child: Care, Health & Development 28 (s1), 3-6.
doi: 10.1046/
j.1365-2214.2002.00001.x

Vaccination News Home Page

ALL INFORMATION, DATA, AND MATERIAL CONTAINED, PRESENTED, OR PROVIDED HERE IS FOR GENERAL INFORMATION PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS REFLECTING THE KNOWLEDGE OR OPINIONS OF THE PUBLISHER, AND IS NOT TO BE CONSTRUED OR INTENDED AS PROVIDING MEDICAL OR LEGAL ADVICE. THE DECISION WHETHER OR NOT TO VACCINATE IS AN IMPORTANT AND COMPLEX ISSUE AND SHOULD BE MADE BY YOU, AND YOU ALONE, IN CONSULTATION WITH YOUR HEALTH CARE PROVIDER.