Preadolescent non- and hyporesponders following three doses of hepatitis B vaccine need only one more dose

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http://www.elsevier.com/gej-ng/10/42/35/60/75/28/abstract.html

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Vaccine, Vol. 20 (31-32) (2002) pp. 3632-3634
© 2002 Elsevier Science Ltd. All rights reserved.
PII: S0264-410X(02)00377-8
 

Short communication

Preadolescent non- and hyporesponders following three doses of hepatitis B vaccine need only one more dose

Bernard Duval a,b * bernard.duval@ssss.gouv.qc.ca , Nicole Boulianne a,b, Gaston De Serres a,b, Philippe De Wals a,b, Richard Massé c and Gisèle Trudeau c

a Institut National de Santé Publiqùe du Québec, 2400 rue d'Estimauville, Beauport, Qué., Canada G1E 7G9
b Unité de recherche en santé publique, Centre hospitalier universitaire de Québec, Institut National de santé publique du Québec, Université Laval, Québec, Qué., Canada
c Ministère de la Santé et des Services sociaux, du Québec, Québec, Qué., Canada G1T 2K4

Received 17 March 2002; received in revised form 15 July 2002; accepted 26 July 2002

Abstract

A small proportion of healthy children fail to develop antibodies against hepatitis B after three doses of vaccine. Few data are available regarding the optimal re-immunization strategy. We measured the immune response 1 month after a single supplementary dose of recombinant hepatitis B vaccines in 18 young preadolescents who were non- or hyporesponsive after a regular primary course of three doses of recombinant hepatitis B vaccines. Among them, 100% seroconverted and 89% reached the seroprotective titer of 10milli-International Units (mIU)/ml. Most healthy children, particularly if they are hyporesponders, will have reached the seroprotective level after one dose and will not need further injections.

Keywords: Hepatitis B vaccine; Revaccination; Preadolescents

*Corresponding author. Tel.: +418-666-7000x234; fax: +418-666-2776.

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