Parental medication use and risk of childhood acute lymphoblastic leukemia

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Online ISSN: 1097-0142    Print ISSN: 0008-543X
Cancer
Volume 95, Issue 8, 2002. Pages: 1786-1794

Published Online: 3 Oct 2002
 

Copyright © 2002 American Cancer Society

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 Original Article
 

Parental medication use and risk of childhood acute lymphoblastic leukemia
Wanqing Wen, M.D. 1, Xiao Ou Shu, M.D., Ph.D. 1 *, John D. Potter, M.D., Ph.D. 2, Richard K. Severson, Ph.D. 3, Jonathan D. Buckley, M.D., Ph.D. 4, Gregory H. Reaman, M.D. 5, Leslie L. Robison, Ph.D. 6
1Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee
2Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, Washington
3Karmanos Cancer Institute, Detroit, Michigan
4School of Medicine, University of Southern California, Los Angeles, California
5Department of Pediatric Hematology/Oncology, Children's National Medical Canter, Washington, DC
6Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
 
email: Xiao Ou Shu (Xiao-Ou.Shu@mcmail.vanderbilt.edu)

*Correspondence to Xiao Ou Shu, Department of Medicine, Vanderbilt Children's Hospital, 6th Floor, Medical Center East, Room 6009, Nashville, TN 37232-8300

Fax: (615) 936-1269

Funded by:
 National Cancer Institute; Grant Number: CA 49450, CA 13539
 National Institutes of Health
 Department of Health and Human Services
 Children's Cancer Research Fund

 

Keywords
medication • child • acute lymphoblastic leukemia

 

Abstract

BACKGROUND
Few studies have examined the risk of childhood acute lymphoblastic leukemia (ALL) associated with parental medication use. As part of a large case-control study conducted by the Children's Cancer Group, we evaluated the association between maternal and paternal medication use and the risk of ALL in offspring.

METHODS
Information on selected medication use in the year before and during the index pregnancy was obtained by telephone interview. Participants included 1842 children of 14 years or younger with newly diagnosed and immunophenotypically defined ALL and 1986 individually matched controls. Data were analyzed using logistic regression models and stratified by immunophenotypes of ALL and age at diagnosis of cases.

RESULTS
After adjusting for potential confounders and other medication use, we found that maternal use of vitamins (odds ratio [OR] = 0.7, 99% confidence interval [CI]: 0.5-1.0) and iron supplements (OR = 0.8, 99% CI: 0.7-1.0) only during the index pregnancy was associated with a decreased risk of ALL. Parental use of amphetamines or diet pills and mind-altering drugs before and during the index pregnancy was related to an increased risk of childhood ALL, particularly among children where both parents reported using these drugs (OR = 2.8, 99% CI: 0.5-15.6 for amphetamines or diet pills, OR = 1.8, 99% CI: 1.1-3.0 for mind-altering drugs). Stratified analyses showed that maternal use of antihistamines or allergic remedies and parental use of mind-altering drugs were strongly associated with infant ALL, whereas patterns of association between childhood ALL and parental medication use did not influence markedly the immunophenotypic subgroup of ALL.

CONCLUSIONS
The findings of this study suggest that certain parental medication use immediately before and during the index pregnancy may influence risk of ALL in offspring. Cancer 2002;95:1786-94. © 2002 American Cancer Society.
DOI 10.1002/cncr.10859

Received: 23 October 2001; Revised: 14 May 2002; Accepted: 20 May 2002

 

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10.1002/cncr.10859  About DOI


 

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