http://care.diabetesjournals.org/cgi/content/abstract/25/11/1969
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Diabetes Care 25:1969-1975, 2002
© 2002 by the
American Diabetes Association, Inc.
Epidemiology/Health Services/Psychosocial Research
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1 School of Nursing, University of Pennsylvania,
Philadelphia, Pennsylvania
2 Department of Neurosurgery, University of Pittsburgh, Pittsburgh,
Pennsylvania
3 The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
OBJECTIVE—To determine the epidemiology of type 1 diabetes in children in Philadelphia from 1990 to 1994, and to identify whether an epidemic occurred during that time period.
RESEARCH DESIGN AND METHODS—This is a descriptive epidemiological study using a retrospective population-based registry in Philadelphia, PA, a city with large white, African-American, and Hispanic (Puerto Rican) populations. All hospitals in Philadelphia that admit children were identified. All charts meeting the following criteria were reviewed: 1) newly diagnosed type 1 diabetes, 2) children 0–14 years of age, 3) children residing in Philadelphia at the time of diagnosis, and 4) those diagnosed from 1 January 1990 to 31 December 1994. Standard type 1 diabetes registry data were abstracted from the charts. Ascertainment of the completeness of the hospital registry was validated by data from the Philadelphia School District. Communicable disease records were reviewed to identify epidemics from 1987 to 1995.
RESULTS—A total of 209 cases were identified, and the
combined hospital and school registry was determined to be 96%
complete. The overall age-adjusted incidence rate in Philadelphia was
13.3/100,000/year. The highest rate by race continues to be in the
Hispanic population (15.5). The incidence in African-American
children has increased markedly (12.8), particularly in the 10- to
14-year age-group (22.9). An epidemic of type 1 diabetes occurred
from January to June 1993, 
2 years after a
measles epidemic in Philadelphia.
CONCLUSIONS—The overall incidence of type 1 diabetes in Philadelphia is similar to other U.S. registries. The incidence in the Hispanic population continues to be among the highest of any U.S. ethnic group. The marked increase in incidence in the African-American population may be due in part to misclassification of cases actually having type 2 diabetes. The 1993 epidemic may have been due to ß-cell autoimmunity triggered by the measles virus.
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Copyright © 2002 by the American Diabetes Association.
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