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Diminished Antibody Response to Hepatitis B Immunization in Children With Sickle Cell Diseasehttp://ipsapp003.lwwonline.com/content/getfile/3183/16/10/abstract.htm
Diminished Antibody Response to Hepatitis B Immunization in Children With Sickle Cell DiseaseSummary:Hepatitis B surface antibody titers were routinely measured in 150 children with sickle cell disease (SCD) after immunization, and the seroconversion rate was found to be lower than that in the general population (89% vs. 97%, P = 0.002). Most of the children who did not seroconvert after the series of 3 immunizations responded to booster injections (93%). Therefore, we recommend the measurement of hepatitis B surface antibody titers after immunization in those children with SCD at greatest risk for hepatitis B infection. An additional dose of hepatitis B vaccine should be administered to those without evidence of seroconversion.
Key Words:
Submitted for publication November 1, 2001; accepted December 10, 2001. From the Departments of Pediatric Hematology/Oncology, Children's Hospital Medical Center of Akron, Akron, Ohio (J.H.); Pediatric Hematology/Oncology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania (B.W.); Medical Oncology, Astrazeneca Pharmaceuticals, Wilmington, Delaware (M.K.); Pediatric Hematology/Oncology, University of North Carolina, Chapel Hill, North Carolina (J.B.); Family Medicine and Clinical Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania (J.J.); and St. Jude Children's Research Hospital, Memphis, Tennessee (J.M.). Address correspondence and reprint requests to Jeffrey D. Hord, M.D., Division of Pediatric Hematology/Oncology, Children's Hospital Medical Center of Akron, One Perkins Square, Akron, OH 44308. E-mail: jhord@ chmca.org.
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DISCLAIMER: All information, data, and material contained, presented, or provided here is for general information purposes only and is not to be construed as reflecting the knowledge or opinions of the publisher, and is not to be construed or intended as providing medical or legal advice. The decision whether or not to vaccinate is an important and complex issue and should be made by you, and you alone, in consultation with your health care provider.
Copyright 2012 by Vaccination News, A Non-Profit Corporation. All Rights Reserved. This content may not be copied unless permission in writing from Sandy Gottstein has been obtained. 
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 "A foolish faith in authority is the worst enemy of truth." -- Albert Einstein, letter to a friend, 1901 "I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education." -- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820 "What's the point of vaccination if it doesn't protect you from the unvaccinated?" -- Sandy Gottstein "Who gets to decide what the greater good is and how many will be sacrificed to it?" -- Sandy Gottstein |
