http://www.journals.uchicago.edu/JID/journal/issues/v186n9/020594/brief/020594.abstract.html
The Journal of Infectious Diseases 2002;186:1358-1361
© 2002 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2002/18609-0022$15.00
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CONCISE COMMUNICATION
Combinations of Protein Polysaccharide Conjugate Vaccines for Intranasal Immunization
Mildred Ugozzoli, Massimo Mariani, Giuseppe Del Giudice, Elawati Soenawan and Derek T. O'Hagan
Chiron Corporation, Emeryville, California
Received 22 May 2002; revised 10 July 2002; electronically published 8 October 2002.
| The ability of 2 mutants of heat-labile
Escherichia coli enterotoxin (LTK63 and LTR72) to enhance the
immunogenicity of 2 protein polysaccharide conjugate
vaccines, Neisseria meningitidis group C (MenC) and
Haemophilus influenzae type B (Hib), both of which
are conjugated to the nontoxic mutant of diphtheria
toxin (CRM197), after intranasal (inl) immunization in
mice was evaluated. In addition, the question of
whether combining both vaccines in a single
formulation with heat-labile E. coli enterotoxin mutants
reduced the response to either vaccine was
investigated. The results showed that potent serum
antibody responses against MenC and Hib could be
elicited by inl immunization in combination with the
mucosal adjuvants. Moreover, IgA mucosal responses were
induced only in animals immunized through the inl
route. Finally, the coadministration of 2 conjugate
vaccines simultaneously did not adversely affect the
responses against either. These studies support the
rationale for developing mucosal vaccines, based on
combining protein polysaccharide conjugates with heat-labile
E. coli enterotoxin mutants, for infants and young
children.
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