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Abstract Journal of Paediatrics and Child Health Volume 38 Issue 5 Page 445  - October 2002   Childhood invasive pneumococcal disease in Tasmania, 19942000 DJF Christie1 DJ Coleman2 X Wan2 MA Jacobs2 and JR Carapetis3 Objective: To describe the burden of invasive pneumococcal disease in Tasmanian children, including age-specific incidence and antibiotic-resistance pattern. Methods: A population-based retrospective study was carried out, examining cases of childhood disease associated with isolates of Streptococcus pneumoniae from normally sterile sites, identified via scrutiny of laboratory records at all major Tasmanian laboratories during a 7-year period between January 1994 and December 2000. Medical records were sub­sequently examined for information describing the clinical syndrome and course of disease. Results: Invasive pneumococcal disease was identified in 76 children during the 7-year period. The incidence per 100 000 children was 28.5 (95% CI 22.036.3) in children under 5 years and 54.3 (95% CI 40.271.8) in children under 2 years. The incidence of meningitis in children younger than 2 years was 12.2 (95% CI 6.121.8). Penicillin resistance was observed in 2.6% of cases, with no high level resistance. Predisposing conditions were identified in 34% of children with invasive disease. Conclusions: The incidence of invasive pneumococcal disease was comparable to many urban populations in Australia. The high rate of predisposing conditions supports the recommendations of the Australian Technical Advisory Group on Immunisation for targeted immunization in this group. The paucity of data describing Indigenous status is an argument for improved data collection in this area. The low level of penicillin resistance necessitates ongoing surveillance, and the lack of serotype information requires prospective data collection.	QuickSearch in: PubMed (MEDLINE) Synergy for Authors: DJF Christie DJ Coleman X Wan MA Jacobs JR Carapetis Key words: age-specific incidence antibiotic resistance Streptococcus pneumoniae surveillance   Affiliations 1Department of Paediatrics, Royal Hobart Hospital, 2Public and Environmental Health Service, Department of Health and Human Services, Hobart, Tasmania and 3Centre for International Child Health, Department of Paediatrics, University of Melbourne, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia   Correspondence Correspondence: Mr DJ Coleman, Public and Environmental Health Service, Department of Health and Human Services, Hobart, Tas. 7000, Australia. Fax: +61 3 6233 6620; email: david.coleman@dhhs.tas.gov.au To cite this article Christie, DJF, Coleman, DJ, Wan, X, Jacobs, MA & Carapetis, JR Childhood invasive pneumococcal disease in Tasmania, 19942000. Journal of Paediatrics and Child Health 38 (5), 445-449. doi: 10.1046/ j.1440-1754.2002.00035.x
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