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http://www.journals.uchicago.edu/CID/journal/issues/v35n10/020065/brief/020065.abstract.html

Clinical Infectious Diseases    2002;35:000
© 2002 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2002/3510-00XX$15.00

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Antimicrobial Use and Serotype Distribution of Nasopharyngeal Streptococcus pneumoniae Isolates Recovered from Greek Children Younger than 2 Years Old

George A. Syrogiannopoulos, George D. Katopodis, Ioanna N. Grivea, and Nicholas G. Beratis

Department of Pediatrics, Division of Infectious Disease, University of Patras, School of Medicine, General University Hospital, Patras, Greece

 

Received 9 January 2002; accepted 18 July 2002; electronically published 21 October 2002.

The serotype distribution of 781 nasopharyngeal pneumococcal isolates recovered from 2448 unselected children aged 223 months was studied. Only 3.9% of the children for whom cultures were performed attended day care centers. The proportions of pneumococcal isolates that belonged to serotypes related to the 7-, 9- and 11-valent conjugate pneumococcal vaccine were 65%, 66%, and 70%, respectively. The pneumococcal carriage rate among untreated children was 34%; the rates among children treated with antibiotics during the periods 130 or 3160 days before the time of nasopharyngeal sampling were 25% and 36%, respectively. There was a significant positive association between antimicrobial use and carriage of antibiotic-resistant pneumococci, which belonged mainly to vaccine-related serotypes. The proportion of isolates that belonged to vaccine-related serotypes in untreated carriers was 72%; however, the proportions in carriers treated 130 days or 3160 days before sampling were 66% and 56%, respectively. In the nasopharynx, antimicrobial use selects for antibiotic-resistant pneumococci, mainly of vaccine-related serotypes, whereas it may promote an increase in the frequency of colonization with nonvaccine serotypes.

     Presented in part: 3rd International Symposium on Pneumococci and Pneumococcal Diseases, Anchorage, Alaska, May 2002 (abstract P-03, 52A).
     Financial support: Wyeth Vaccines.

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