http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2107522&dopt=Abstract
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Pediatrics 1990 Apr;85(4 Pt 2):698-704 |
Disease caused by Haemophilus influenzae type
b in the immediate period after homologous immunization: immunologic
investigation.
Sood SK, Daum RS.
Department of Pediatrics, Tulane University School of Medicine, New Orleans,
Louisiana.
Several Haemophilus influenzae type b vaccines have been licensed and
recommended for administration to children in the United States. These vaccines
have consisted of purified polyribosylribitol-phosphate (PRP), the capsular
polysaccharide of H influenzae type b, alone or covalently bound to one of
several carrier proteins. Two of these saccharide-protein conjugate vaccines
are now licensed, a polysaccharide-diphtheria toxoid conjugate (PRP-D) and an
oligosaccharide-mutant diphtheria toxin conjugate (HbOC). Two others, a
polysaccharide-Neisseria meningitidis outer membrane protein conjugate
(PRP-OMPC) and a polysaccharide-tetanus toxoid conjugate (PRP-T), are currently
in clinical trials. One concern with the use of PRP vaccine was the suggestion
that the incidence of invasive disease caused by H influenzae type b in the
immediate period after immunization might be increased; this idea was supported
by evidence from several sources. In a case-control study of the efficacy of
PRP vaccine, Black et al found that 4 children were hospitalized for invasive
disease within 1 week of immunization, a rate of invasive disease 6.4 times
greater (95% confidence interval [CI], 2.1 to 19.2) than the background rate in
unvaccinated children. In Minnesota, the relative risk for invasive disease in
the first week after immunization was 6.2 (95% CI, 0.6 to 45.9), and the
results of a study conducted by the Centers for Disease Control in six areas of
the United States revealed a 1.8-fold (95% CI, 0.3 to 10.2) increase in the occurrence
of invasive disease caused by H influenzae type b in the first week after
immunization.(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Types:
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Review
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Review, Tutorial
PMID: 2107522 [PubMed - indexed for MEDLINE]
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