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http://www.journals.uchicago.edu/JID/journal/issues/v186n12/020743/brief/020743.abstract.html

The Journal of Infectious Diseases    2002;186:1840-1843
© 2002 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2002/18612-0020$15.00

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CONCISE COMMUNICATION

Fc Receptor IIIA Polymorphism as a Risk Factor for Acute Poliomyelitis

Tiina Rekand,¹ Nina Langeland,² Johan A. Aarli,¹ and Christian A. Vedeler¹

Departments of ¹Neurology and ²Internal Medicine, Haukeland University Hospital, Bergen, Norway

Received 24 June 2002; revised 28 August 2002; electronically published 19 November 2002.

Poliomyelitis is a viral infection that causes flaccid paralysis in 1% of cases. The Fc receptors for immunoglobulin G (FcR) are associated with modifying effects of several infectious and autoimmune diseases. To assess the influence of FcR polymorphisms on the acute and late course of poliomyelitis, 110 Norwegian patients with well-defined histories of acute poliomyelitis were genotyped, of whom 50 suffered from the postpolio syndrome (PPS). In comparison with healthy control subjects without a history of poliomyelitis, significantly fewer patients had the FcRIIIA genotype V/V (P < .01). However, this genotype was not an independent risk factor for PPS. The FcRIIA and IIIB genotypes and allele frequencies did not differ between the patients and control subjects. The FcRIIIA V/V genotype may lower the risk for contracting acute poliomyelitis through better clearance of poliovirus.

     Informed consent was obtained from all patients and controls. Study protocol follows the ethical standards established in the 1964 Helsinki Declaration.
     The study was approved by the Regional Research Ethics committee.
     Financial support: Sophies Minde Foundation.

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