Immune impairment in autism re: medical exemption from vaccination by Teresa Binstock
Families with autism merit exemptions from forced vaccinations. A range
of
immune impairments are documented in autism. Some of these impairments can be
acquired, some are *genetic*. Those that are genetic are thus *familial* -- in
that the father or mother is carrying the immune-impairing gene (eg, a null
allele for C4b). Siblings may also carry such gene alleles.
As a result, autistic children and their families should be exempted from
dangerous vaccinations. Furthermore, the genetic immune weaknesses identified in
autism will extend to other family members, ie, to individuals outside the
autistic child's immediate family. Without specific genetic testing of the
autistic child's extended family, there is no way to know in advance which
extended family-member has a genetic immune weakness that will incline that
individual towards adverse effects from "smallpox" vaccination via the vaccinia
virus.
Categories of exempted individuals and their families must include families with
autism and their relatives. Herewith are 42 citations documenting immune
irregularities in autism. A law that does not call attention to autistic
families ought not be passed.
Teresa Binstock
Researcher in Developmental & Behavioral Neuroanatomy
References:
1: Jyonouchi H, Sun S, Itokazu N.
Innate Immunity Associated with Inflammatory Responses and Cytokine Production
against Common Dietary Proteins in Patients with Autism Spectrum Disorder.
Neuropsychobiology. 2002;46(2):76-84.
PMID: 12378124 [PubMed - in process]
2: Krause I, He XS, Gershwin ME, Shoenfeld Y.
Brief report: immune factors in autism: a critical review.
J Autism Dev Disord. 2002 Aug;32(4):337-45.
PMID: 12199139 [PubMed - in process]
3: Kidd PM.
Autism, an extreme challenge to integrative medicine. Part: 1: The knowledge
base.
Altern Med Rev. 2002 Aug;7(4):292-316. Review.
PMID: 12197782 [PubMed - indexed for MEDLINE]
4: Vojdani A, Campbell AW, Anyanwu E, Kashanian A, Bock K, Vojdani E.
Antibodies to neuron-specific antigens in children with autism: possible
cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae
and Streptococcus group A.
J Neuroimmunol. 2002 Aug;129(1-2):168-77.
PMID: 12161033 [PubMed - indexed for MEDLINE]
5: Singh VK, Lin SX, Newell E, Nelson C.
Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with
autism.
J Biomed Sci. 2002 Jul-Aug;9(4):359-64.
PMID: 12145534 [PubMed - in process]
6: Wakefield AJ, Puleston JM, Montgomery SM, Anthony A, O'Leary JJ, Murch SH.
Review article: the concept of entero-colonic encephalopathy, autism and opioid
receptor ligands.
Aliment Pharmacol Ther. 2002 Apr;16(4):663-74. Review.
PMID: 11929383 [PubMed - indexed for MEDLINE]
7: Korvatska E, Van de Water J, Anders TF, Gershwin ME.
Genetic and immunologic considerations in autism.
Neurobiol Dis. 2002 Mar;9(2):107-25. Review.
PMID: 11895365 [PubMed - indexed for MEDLINE]
8: Jyonouchi H, Sun S, Le H.
Proinflammatory and regulatory cytokine production associated with innate and
adaptive immune responses in children with autism spectrum disorders and
developmental regression.
J Neuroimmunol. 2001 Nov 1;120(1-2):170-9.
PMID: 11694332 [PubMed - indexed for MEDLINE]
9: Hornig M, Lipkin WI.
Infectious and immune factors in the pathogenesis of neurodevelopmental
disorders: epidemiology, hypotheses, and animal models.
Ment Retard Dev Disabil Res Rev. 2001;7(3):200-10. Review.
PMID: 11553936 [PubMed - indexed for MEDLINE]
10: Torres AR, Maciulis A, Odell D.
The association of MHC genes with autism.
Front Biosci. 2001 Aug 1;6:D936-43. Review.
PMID: 11487481 [PubMed - indexed for MEDLINE]
11: Malek-Ahmadi P.
Cytokines and etiopathogenesis of pervasive developmental disorders.
Med Hypotheses. 2001 Mar;56(3):321-4.
PMID: 11359354 [PubMed - indexed for MEDLINE]
12: Binstock T.
Intra-monocyte pathogens delineate autism subgroups.
Med Hypotheses. 2001 Apr;56(4):523-31.
PMID: 11339860 [PubMed - indexed for MEDLINE]
13: Gupta S.
Immunological treatments for autism.
J Autism Dev Disord. 2000 Oct;30(5):475-9.
PMID: 11098887 [PubMed - indexed for MEDLINE]
14: Fiumara A, Sciotto A, Barone R, D'Asero G, Munda S, Parano E, Pavone L.
Peripheral lymphocyte subsets and other immune aspects in Rett syndrome.
Pediatr Neurol. 1999 Sep;21(3):619-21.
PMID: 10513687 [PubMed - indexed for MEDLINE]
15: Comi AM, Zimmerman AW, Frye VH, Law PA, Peeden JN.
Familial clustering of autoimmune disorders and evaluation of medical risk
factors in autism.
J Child Neurol. 1999 Jun;14(6):388-94.
PMID: 10385847 [PubMed - indexed for MEDLINE]
16: Connolly AM, Chez MG, Pestronk A, Arnold ST, Mehta S, Deuel RK.
Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other
neurologic disorders.
J Pediatr. 1999 May;134(5):607-13.
PMID: 10228297 [PubMed - indexed for MEDLINE]
17: Gupta S.
Treatment of children with autism with intravenous immunoglobulin.
J Child Neurol. 1999 Mar;14(3):203-5. No abstract available.
PMID: 10190273 [PubMed - indexed for MEDLINE]
18: Singh VK, Lin SX, Yang VC.
Serological association of measles virus and human herpesvirus-6 with brain
autoantibodies in autism.
Clin Immunol Immunopathol. 1998 Oct;89(1):105-8.
PMID: 9756729 [PubMed - indexed for MEDLINE]
19: Gupta S, Aggarwal S, Rashanravan B, Lee T.
Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism.
J Neuroimmunol. 1998 May 1;85(1):106-9.
PMID: 9627004 [PubMed - indexed for MEDLINE]
20: Plioplys AV.
Intravenous immunoglobulin treatment of children with autism.
J Child Neurol. 1998 Feb;13(2):79-82.
PMID: 9512308 [PubMed - indexed for MEDLINE]
21: Messahel S, Pheasant AE, Pall H, Ahmed-Choudhury J, Sungum-Paliwal RS,
Vostanis P.
Urinary levels of neopterin and biopterin in autism.
Neurosci Lett. 1998 Jan 23;241(1):17-20.
PMID: 9502205 [PubMed - indexed for MEDLINE]
22: Singh VK, Warren R, Averett R, Ghaziuddin M.
Circulating autoantibodies to neuronal and glial filament proteins in autism.
Pediatr Neurol. 1997 Jul;17(1):88-90.
PMID: 9308986 [PubMed - indexed for MEDLINE]
23: Warren RP, Odell JD, Warren WL, Burger RA, Maciulis A, Daniels WW, Torres
AR.
Brief report: immunoglobulin A deficiency in a subset of autistic subjects.
J Autism Dev Disord. 1997 Apr;27(2):187-92. No abstract available.
PMID: 9105969 [PubMed - indexed for MEDLINE]
24: Singh VK, Singh EA, Warren RP.
Hyperserotoninemia and serotonin receptor antibodies in children with autism but
not mental retardation.
Biol Psychiatry. 1997 Mar 15;41(6):753-5. No abstract available.
PMID: 9067002 [PubMed - indexed for MEDLINE]
25: van Gent T, Heijnen CJ, Treffers PD.
Autism and the immune system.
J Child Psychol Psychiatry. 1997 Mar;38(3):337-49. Review.
PMID: 9232480 [PubMed - indexed for MEDLINE]
26: Gupta S, Aggarwal S, Heads C.
Dysregulated immune system in children with autism: beneficial effects of
intravenous immune globulin on autistic characteristics.
J Autism Dev Disord. 1996 Aug;26(4):439-52. No abstract available.
PMID: 8863094 [PubMed - indexed for MEDLINE]
27: Warren RP, Odell JD, Warren WL, Burger RA, Maciulis A, Daniels WW, Torres
AR.
Strong association of the third hypervariable region of HLA-DR beta 1 with
autism.
J Neuroimmunol. 1996 Jul;67(2):97-102.
PMID: 8765331 [PubMed - indexed for MEDLINE]
28: Singh VK.
Plasma increase of interleukin-12 and interferon-gamma. Pathological
significance in autism.
J Neuroimmunol. 1996 May;66(1-2):143-5.
PMID: 8964908 [PubMed - indexed for MEDLINE]
29: Warren RP, Singh VK, Averett RE, Odell JD, Maciulis A, Burger RA, Daniels
WW, Warren WL.
Immunogenetic studies in autism and related disorders.
Mol Chem Neuropathol. 1996 May-Aug;28(1-3):77-81. Review.
PMID: 8871944 [PubMed - indexed for MEDLINE]
30: Daniels WW, Warren RP, Odell JD, Maciulis A, Burger RA, Warren WL, Torres
AR.
Increased frequency of the extended or ancestral haplotype B44-SC30-DR4 in
autism.
Neuropsychobiology. 1995;32(3):120-3.
PMID: 8544967 [PubMed - indexed for MEDLINE]
31: Warren RP, Yonk J, Burger RW, Odell D, Warren WL.
DR-positive T cells in autism: association with decreased plasma levels of the
complement C4B protein.
Neuropsychobiology. 1995;31(2):53-7.
PMID: 7760985 [PubMed - indexed for MEDLINE]
32: Warren RP, Burger RA, Odell D, Torres AR, Warren WL.
Decreased plasma concentrations of the C4B complement protein in autism.
Arch Pediatr Adolesc Med. 1994 Feb;148(2):180-3.
PMID: 8118537 [PubMed - indexed for MEDLINE]
33: Plioplys AV, Greaves A, Kazemi K, Silverman E.
Lymphocyte function in autism and Rett syndrome.
Neuropsychobiology. 1994;29(1):12-6.
PMID: 8127418 [PubMed - indexed for MEDLINE]
34: Warren RP, Singh VK, Cole P, Odell JD, Pingree CB, Warren WL, DeWitt CW,
McCullough M.
Possible association of the extended MHC haplotype B44-SC30-DR4 with autism.
Immunogenetics. 1992;36(4):203-7.
PMID: 1639438 [PubMed - indexed for MEDLINE]
35: Warren RP, Singh VK, Cole P, Odell JD, Pingree CB, Warren WL, White E.
Increased frequency of the null allele at the complement C4b locus in autism.
Clin Exp Immunol. 1991 Mar;83(3):438-40.
PMID: 2004485 [PubMed - indexed for MEDLINE]
36: Yonk LJ, Warren RP, Burger RA, Cole P, Odell JD, Warren WL, White E, Singh
VK.
CD4+ helper T cell depression in autism.
Immunol Lett. 1990 Sep;25(4):341-5.
PMID: 1979061 [PubMed - indexed for MEDLINE]
37: Warren RP, Yonk LJ, Burger RA, Cole P, Odell JD, Warren WL, White E, Singh
VK.
Deficiency of suppressor-inducer (CD4+CD45RA+) T cells in autism.
Immunol Invest. 1990 Jun;19(3):245-51.
PMID: 2142123 [PubMed - indexed for MEDLINE]
38: Warren RP, Foster A, Margaretten NC.
Reduced natural killer cell activity in autism.
J Am Acad Child Adolesc Psychiatry. 1987 May;26(3):333-5. No abstract available.
PMID: 3597287 [PubMed - indexed for MEDLINE]
39: Warren RP, Margaretten NC, Pace NC, Foster A.
Immune abnormalities in patients with autism.
J Autism Dev Disord. 1986 Jun;16(2):189-97.
PMID: 2941410 [PubMed - indexed for MEDLINE]
40: Weizman A, Weizman R, Szekely GA, Wijsenbeek H, Livni E.
Abnormal immune response to brain tissue antigen in the syndrome of autism.
Am J Psychiatry. 1982 Nov;139(11):1462-5.
PMID: 6182806 [PubMed - indexed for MEDLINE]
41: Stubbs EG, Crawford ML.
Depressed lymphocyte responsiveness in autistic children.
J Autism Child Schizophr. 1977 Mar;7(1):49-55.
PMID: 139400 [PubMed - indexed for MEDLINE]
42: Stubbs EG.
Autistic children exhibit undetectable hemagglutination-inhibition antibody
titers despite previous rubella vaccination.
J Autism Child Schizophr. 1976 Sep;6(3):269-74.
PMID: 1036494 [PubMed - indexed for MEDLINE]
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