http://www.elsevier.com/gej-ng/10/42/35/80/25/43/abstract.html
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Vaccine, Vol. 21 (1-2) (2002) pp. 138-145
© 2002 Elsevier Science Ltd. All rights reserved.
PII: S0264-410X(02)00348-1
a Swedish Institute for Infectious Disease Control,
Solna, Sweden
b Department of Microbiology, Universidad Nacional
Autónoma de Nicaragua, León, Sweden
c SBL Vaccin AB, Solna, Sweden
d GlaxoSmithKline, P.O. Box 528, 183 25 Taby,
Stockholm, Sweden
Received 16 January 2001; received in revised form 3 April 2002; accepted 8 July 2002
Serum responses to oral cholera vaccines were assessed in three paediatric vaccine trials, two in León, Nicaragua and one in Stockholm, Sweden. A calibrated anti-cholera toxin B subunit (CTB) IgA ELISA was used together with an assay for vibriocidal antibodies. Swedish children had lower pre-vaccination levels of antibody, but serum responses were more pronounced in Swedish children than in Nicaraguan children. Post-vaccination levels of anti-toxin antibody were generally above those found after natural infections with enterotoxigenic Escherichia coli, that cross-reacts serologically with Vibrio cholerae. Adverse events seen after vaccination were generally mild and of little clinical significance.
Keywords: Serum response; Cholera vaccine; Technique
*Corresponding author. Tel.: +46-8-638-93-57; fax: +46-8-638-94-60.
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