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"Antibody Persistence and Immunological Memory at Age 4 Years After Meningococcal Group C Conjugate Vaccination in Children in the United Kingdom"Immunization Newsbriefs (c) Copyright Information Inc., Bethesda, MD. Brought to you by the National Network for Immunization Information (NNii). Visit NNii's new website at http://www.immunizationinfo.org.
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November 15, 2002
INTERNATIONAL IMMUNIZATION NEWS
"Antibody Persistence and Immunological Memory at Age 4 Years After Meningococcal Group C Conjugate Vaccination in Children in the United Kingdom" Journal of Infectious Diseases (www.journals.uchicago.edu/JID/home.html) (11/01/2002) Vol. 186, No. 9, P. 1353; Borrow, Ray; Goldblatt, David; Andrews, Nick
Children were primed with two different formulations of a meningococcal group C conjugate vaccine, with either 2 micrograms or 10 micrograms of meningococcal C polysaccharide at two months, three months, and four months of age. In order to determine the antibody persistence and immunological priming of the formulations, the children were administered booster vaccines between the ages of 13 months and 16 months and again at four years with 10 micrograms of unconjugated meningococcal C polysaccharide. At four years, tests showed that geometric mean titers, concentrations of meningococcal C-specific immunoglobulin G, and concentrations of serum bactericidal antibody had dropped to levels seen before vaccination. One month after the year-four booster, meningococcal C immunoglobulin G and serum bactericidal antibody levels had risen significantly. The 2-microgram vaccination provided a greater post-booster reaction than the 10-microgram vaccination, the researchers said. ALL INFORMATION, DATA, AND
MATERIAL CONTAINED, PRESENTED, OR PROVIDED HERE IS FOR GENERAL INFORMATION
PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS REFLECTING THE KNOWLEDGE OR OPINIONS
OF THE PUBLISHER, AND IS NOT TO BE CONSTRUED OR INTENDED AS PROVIDING MEDICAL OR
LEGAL ADVICE. THE DECISION WHETHER OR NOT TO VACCINATE IS AN IMPORTANT AND
COMPLEX ISSUE AND SHOULD BE MADE BY YOU, AND YOU ALONE, IN CONSULTATION WITH
YOUR HEALTH CARE PROVIDER.
DISCLAIMER: All information, data, and material contained, presented, or provided here is for general information purposes only and is not to be construed as reflecting the knowledge or opinions of the publisher, and is not to be construed or intended as providing medical or legal advice. The decision whether or not to vaccinate is an important and complex issue and should be made by you, and you alone, in consultation with your health care provider.
Copyright 2012 by Vaccination News, A Non-Profit Corporation. All Rights Reserved. This content may not be copied unless permission in writing from Sandy Gottstein has been obtained. 
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 "A foolish faith in authority is the worst enemy of truth." -- Albert Einstein, letter to a friend, 1901 "I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education." -- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820 "What's the point of vaccination if it doesn't protect you from the unvaccinated?" -- Sandy Gottstein "Who gets to decide what the greater good is and how many will be sacrificed to it?" -- Sandy Gottstein |