A highly respected and well-published scientist at the
Utah State University, Vijendra K. Singh has further linked autism to the MMR vaccine.
His study published in New Foundation of Biology, Elsevier Science BV 2001:
447-58 titled Neuro-immunopathogenesis in Autism provides brain autoantibody
and virus serology evidence that links autism to MMR and postulates autism as a
neuroautoimmune response that occurs at the neuroimmune biological interface.
Singh found that autoantibodies to myelin basic proteins
were present in 80% of autistic children but that none were found in the normal
children control group and only rarely in all other controls. These autoantibodies
attack the basic proteins that constitute myelin, which surrounds the sheaths
of nerve fibers. Regarding the virus serology, autistic children had a
significantly higher level of measles virus antibodies as compared to controls,
which suggests a temporal link of measles virus with autoimmunity in autism.
Furthermore, Singh found a very important serological
association between measles antibody level and antiMBP, which showed that the
higher the measles antibody titer the greater the chance of autoantibodies to myelin
basic protein. The shocking fact is that none of the children had a wild-type
measles infection, but they all had the measles mumps rubella (MMR) vaccine.
Singh also offers hope. He notes an open label trial of
oral Sphingolin (myelin containing autoantigen) is being assessed. Preliminary
results show significant improvement in autistic people, which further support the
neuroimmune pathogenesis in autism.
·
transcribed by Susan E. Kreider
Vijendra K. Singh, Department of Biology and Biotechnology
Center, Utah
State University, Logan, Utah, USA 84322-5305
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