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October 2001 Click here to send this page to a friend!

Lymphoma Vaccine

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TAMPA, Fla. (Ivanhoe Newswire) — Modern science has given us vaccines to fight off tetanus, influenza and measles. However, is it possible to create a vaccine that can fight cancer? The key ingredient in an experimental vaccine against Non-Hodgkin's lymphoma may lie within the patient's own body.

For years, attorney Ron Wigginton never worried about his health. "If there was anyone who ever thought they were immortal, I probably, I probably did," he says.

Then a large, painless lump developed on his forehead.

Wigginton says, "Initially intended to go to a plastic surgeon to have it cut out."

Instead, Wigginton was told it was serious — Non-Hodgkin's lymphoma, a common, but often incurable cancer of the lymph glands. According to the National Cancer Institute, average survival time for advanced cases is 10 years. Chemotherapy can put it into remission, but in many cases, the cancer returns, sometimes repeatedly.

"But that remission will be shorter and you can keep doing this over and over again until you get to that 10-year period," says hematologist/oncologist Thomas Loughran, M.D., of the Moffitt Cancer Center in Tampa.

Dr. Loughran is studying a new vaccine designed to keep the lymphoma from coming back. "The vaccine is actually specifically made from the patient's own cancer cells," he says.

The patient's cancer cells are removed, mixed with immune-boosting proteins and saline, and then given back to the patient once the cancer is in remission.

In a small, pilot study of 20 patients, 18 were cancer-free after four years.

Dr. Loughran says, "They developed active killer cells in their blood that specifically recognized their lymphoma."

Wigginton doesn't know yet if the vaccine worked for him, but he hopes it's a step in the right direction for other cancer patients.

The vaccine is being tested on one of the most common types of lymphoma, called follicular Non-Hodgkin's lymphoma. It strikes up to 25,000 people each year in the United States, usually between ages 60 and 65.

If you would like more information, please contact:

Matt Novak

University of South Florida

H. Lee Moffitt Cancer Center

12902 Magnolia Drive

Tampa, Florida 33612-9497

(813) 632-1478

Related Articles:
Hope for Non-Hodgkin's Lymphoma (March 1999)
cancer-Fighting Antibodies (September 1998)

 

ALL INFORMATION, DATA, AND MATERIAL CONTAINED, PRESENTED, OR PROVIDED HERE IS FOR GENERAL INFORMATION PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS REFLECTING THE KNOWLEDGE OR OPINIONS OF THE PUBLISHER, AND IS NOT TO BE CONSTRUED OR INTENDED AS PROVIDING MEDICAL OR LEGAL ADVICE.  THE DECISION WHETHER OR NOT TO VACCINATE IS AN IMPORTANT AND COMPLEX ISSUE AND SHOULD BE MADE BY YOU, AND YOU ALONE, IN CONSULTATION WITH YOUR HEALTH CARE PROVIDER.