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: Pediatrics 1999 Nov;104(5):e59 |
Books
Increased susceptibility to measles in
infants in the United States.
Papania M, Baughman AL, Lee S, Cheek JE, Atkinson W, Redd SC, Spitalny K,
Finelli L, Markowitz L.
National Immunization Program, Epidemiology Program Office, Centers for Disease
Control and Prevention, Atlanta, Georgia 30333, USA.
BACKGROUND: Women born in the United States after measles vaccine licensure in
1963 transfer less measles antibody to their infants than do older women. This
may result in increased susceptibility to measles among infants. OBJECTIVE: To
determine the effect of maternal year of birth on the risk for measles in
infants. METHODS: We enrolled 128 unvaccinated infants </=15 months of age
who had documented exposure to measles from 1990 through 1992 in a
retrospective cohort study. We interviewed their mothers by telephone to obtain
demographic data, medical and vaccination history, and details of measles
exposure and outcome. We used logistic regression analysis to estimate the
effect of maternal year of birth. RESULTS: Infants whose mothers were born
after 1963 had a measles attack rate of 33%, compared with 12% for infants of
older mothers. In logistic regression analysis, the adjusted odds ratio for
maternal year of birth (born after 1963) was 7.5 (95% confidence interval 1.8,
30.6). Other significant risk factors were older infant age, mothers who
developed measles after delivery, and exposure within 2 days of the rash onset
of the exposing case. CONCLUSIONS: Infants whose mothers were born after 1963
are more susceptible to measles than are infants of older mothers. An
increasing proportion of infants born in the United States may be susceptible
to measles. Infants at high risk of exposure to measles should be vaccinated at
12 months of age. Vaccination programs that reduce transmission of the measles
virus in the general population reduce the risk of infant exposure to measles.
PMID: 10545585 [PubMed - indexed for MEDLINE]
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