Illness after influenza vaccination reported through a nationwidesurveillance system, 1976-1977.
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Illness after influenza vaccination reported through a nationwide
surveillance system, 1976-1977.
In 1976, the Center for Disease Control coordinated nationwide surveillance for
illnesses after influenza vaccination as part of an effort to vaccinate the
nation against influenza A/New Jersey/76. For the 48,161,019 persons vaccinated
in 1976, a total of 4733 reports of illness were received which included
reports of 223 deaths. When Guillain-Barre syndrome was reported in vaccine
recipients, an investigation was begun to examine this possible association.
Other than the Guillain-Barre syndrome and rare cases of anaphylaxis, no
serious illnesses were causally associated with influenza vaccination by this
type of surveillance. Widespread underreporting of illness and death in the
passive phase of this surveillance system, however, impaired the ability to
draw conclusions about reactions to vaccine from the reports of illness
received.
PMID: 7361749 [PubMed - indexed for MEDLINE]
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