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: Bangladesh Med Res Counc Bull 1984 Jun;10(1):24-8 |
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Effect of ascorbic acid in the treatment of
tetanus.
Jahan K, Ahmad K, Ali MA.
The effect of daily intravenous administration of 1000 mg ascorbic acid (AA) in
tetanus patients aged 1-30 years was studied. In the age group of 1-12 years,
31 patients were treated with AA as additional to antitetanus serum, sedatives
and antibiotics. It was found that none of the patients died who received AA
along with the conventional antitetanus therapy. On the other hand, 74.2 per
cent of the tetanus patients who received the conventional antitetanus therapy
without AA (control group) were succumbed to the infection. In the other age
group of 13-30 years, there were 27 and 38 patients in the treatment and
control groups respectively. The mortality in the AA and control groups were 37
percent and 67.8 percent respectively. These results suggest that AA might play
an important role in reducing the mortality of tetanus. This was supported by
the fact that AA was found to mitigate the toxic effects of strychnine
producing tetanus like condition in young chicks in the present study.
PMID: 6466264 [PubMed - indexed for MEDLINE]
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