Polysaccharide Vaccines for Prevention of Encapsulated Bacterial Infections: Part 2

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http://www.medscape.com/viewarticle/433131?srcmp=ped-052402

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Polysaccharide Vaccines for Prevention of Encapsulated Bacterial Infections: Part 2


 

from Infections in Medicine ®

Chi-Jen Lee, ScD, Lucia H. Lee, MD, Kaio Koizumi, PhD


 

Abstract and Introduction

Abstract

Variability in the effect of Haemophilus influenzae type b (Hib) polysaccharide vaccines led to the development of Hib conjugate vaccines. Combination vaccines with an Hib conjugate offer continued protection to infants and young children and reduce the number of injections needed. The success of Hib conjugate vaccines has led to conjugate vaccines against other encapsulated pathogens.

 

Introduction

The first part of this article (Infect Med. 2002;19:127-133) discussed the rationale for development of conjugate vaccines and reviewed the status of vaccines against Neisseria meningitidis and Salmonella typhi. This second part examines the prospects for new glycoconjugate vaccines against infection with Haemophilus influenzae type b (Hib) and for development of vaccines for S typhi, group B Streptococcus (GBS), Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

 

 

 

Section 1 of 7 Continue

 
Chi-Jen Lee, ScD, Lucia H. Lee, MD,The Center for Biologics Evaluation and Research, FDA, Bethesda, Md; Kaio Koizumi, PhD; The Microbiological Institute of Tsukuba, Ibaraki, Japan
 


Infect Med 19(4):179-182, 2002. © 2002 Cliggott Publishing, Division of SCP Communications



 

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