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Pneumococcal disease in the young -- what can we do to stop Streptococcus pneumoniae infection? Medscape Pediatrics 4(1) 2002 http://www.medscape.com/viewprogram/1807?srcmp=ped-042602

Read summaries of the latest articles from JAMA, Pediatrics, and more. Medscape Pediatrics 4(1) 2002 http://www.medscape.com/viewarticle/432078?srcmp=ped-042602

RACIAL AND ETHNIC DISPARITIES IN INFANT MORTALITY RATES --- 60 LARGEST U.S. CITIES, 1995--1998 Overall, blacks have higher IMRs, mostly due to a higher percentage of low-birth-weight infants. MMWR 51(15) 2002 http://www.medscape.com/viewarticle/432133?srcmp=ped-042602

ARE SLEEP PROBLEMS LINKED TO INATTENTION AND HYPERACTIVITY? Children who show symptoms of sleep-disordered breathing are more likely to have problems with inattention. Brown University Child and Adolescent Psychopharmacology Update 4(4) 2002 http://www.medscape.com/viewarticle/431307?srcmp=ped-042602

A recent NIAAA study reveals that college drinking is more extensive and destructive than previously thought. Alcoholism & Drug Abuse Weekly 14(15) 2002 http://www.medscape.com/viewarticle/431692?srcmp=ped-042602

PEAK FLOW METERS HELPFUL IN PEDIATRIC ASTHMA MONITORING Asthmatic children who use meters to monitor peak expiratory flow appear to do better than those who rely on symptoms alone to guide management. Reuters Health Information 2002 http://www.medscape.com/viewarticle/432481?srcmp=ped-042602

MIXING DTAP VACCINES DOES NOT AFFECT SAFETY, IMMUNOGENICITY Diphtheria-tetanus-acellular pertussis (DTaP) vaccines may be interchangeable for at least some vaccinations within the 3-dose sequence. MedscapeWire 2002 http://www.medscape.com/viewarticle/432633?srcmp=ped-042602

SAQUINAVIR SUBOPTIMAL IN HIV-POSITIVE CHILDREN UNLESS COMBINED WITH OTHER PIS In HIV-infected children, saquinavir alone does not maintain consistently efficacious plasma levels. Reuters Health Information 2002 http://www.medscape.com/viewarticle/432287?srcmp=ped-042602

CCR5 DENSITY ON CD4 CELLS GOVERNS COURSE OF HIV INFECTION IN CHILDREN The density of CC chemokine receptor 5 (CCR5) molecules on the surface of inactivated CD4 cells correlates with disease progression and with treatment response in children vertically infected with HIV. Reuters Health Information 2002 http://www.medscape.com/viewarticle/432289?srcmp=ped-042602

NEW DRUG COMBINATION FOR MALARIA EFFECTIVE IN AFRICAN CHILDREN A combination of artesunate and amodiaquine improved treatment outcomes of malaria among children in Gabon and Kenya, and was equivalent to amodiaquine-only treatment in Senegal. Reuters Health Information 2002 http://www.medscape.com/viewarticle/432284?srcmp=ped-042602

The combination of amodiaquine and artesunate was superior to amodiaquine alone for the treatment of uncomplicated Plasmodium falciparum malaria in African children. MedscapeWire 2002 http://www.medscape.com/viewarticle/432125?srcmp=ped-042602

PROCALCITONIN BETTER MARKER FOR MENINGOCOCCAL DISEASE THAN C-REACTIVE PROTEIN In children presenting with fever and a rash, the procalcitonin level is an accurate indicator of meningococcal disease. Reuters Health Information 2002 http://www.medscape.com/viewarticle/432456?srcmp=ped-042602

TERBINAFINE FOR TWO WEEKS FOUND BEST FOR TREATMENT OF TINEA CAPITIS In terms of efficacy and compliance, 14 days of treatment with terbinafine appears to be optimal for patients with Trichophyton tinea capitis. Reuters Health Information 2002 http://www.medscape.com/viewarticle/432264?srcmp=ped-042602

CYCLOPHOSPHAMIDE USE CUTS RISK OF SECOND CANCERS IN PEDIATRIC HODGKIN'S DISEASE Use of cyclophosphamide instead of nitrogen mustard in chemotherapy regimens for childhood Hodgkin's lymphoma is credited for a low incidence of second malignancies. Reuters Health Information 2002 http://www.medscape.com/viewarticle/432318?srcmp=ped-042602

AMIFOSTINE AN EFFECTIVE CYTOPROTECTANT IN CHILDREN BEING TREATED FOR OSTEOSARCOMA Amifostine, a drug currently approved in the US for its cytoprotective properties in cancer therapy, reduces myelotoxicity in children and adolescents undergoing chemotherapy for osteosarcoma. Reuters Health Information 2002 http://www.medscape.com/viewarticle/432607?srcmp=ped-042602

INTRAMEDULLARY RODDING EFFECTIVE FOR FEMUR FRACTURES IN SKELETALLY MATURE CHILDREN Intramedullary rodding, a common treatment for femur fractures in adults, also is also effective in children with these fractures, provided they are skeletally mature. Reuters Health Information 2002 http://www.medscape.com/viewarticle/432489?srcmp=ped-042602

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