Lack of Antibody Production Following Immunization in Old
Age: Association with CD8(+)CD28(-) T Cell Clonal Expansions and an Imbalance in
the Production of Th1 and Th2 Cytokines.
Saurwein-Teissl M, Lung TL, Marx F, Gschosser C, Asch E, Blasko I, Parson W,
Bock G, Schonitzer D, Trannoy E, Grubeck-Loebenstein B.
Institute for Biomedical Aging Research of the Austrian Academy of Sciences, and
Institute of Legal Medicine, Institute of Pathophysiology, Central Institute for
Blood Transfusion, University Clinics Innsbruck, Innsbruck, Austria. Aventis-Pasteur,
Marcy l'Etoile, France.
Although it is generally recognized that the function of the immune system
declines with age, the nature of the underlying defects is still poorly
understood. We now demonstrate the predominance of CD8(+)CD28(-) T cell clonal
expansions in elderly persons who fail to produce specific Abs following
influenza vaccination. These clones express effector cell markers and are mostly
CD45RA(+). When isolated and put into culture, they are unable to proliferate,
but produce IFN-gamma (but no IL-5) upon stimulation with anti-CD3 or
autoantigen. These autoreactive CD8(+) type 1 effector cells seem to trigger a
Th1 polarization, as CD4(+) T cells from elderly persons without in vivo Ab
production produce Th1, but only low amounts of Th2 cytokines upon in vitro
stimulation with PHA. Therefore, the increased occurrence of CD8(+)CD28(-)
clonal expansions may be decisive for the development of immune deficiency in
the elderly.
PMID: 12023394 [PubMed - as supplied by publisher]
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