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"Dose-Related Effects of Smallpox Vaccine"Immunization Newsbriefs (c) Copyright Information Inc., Bethesda, MD. Brought to you by the National Network for Immunization Information (NNii). Visit NNii's new website at http://www.immunizationinfo.org.
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May 22, 2002
U.S. IMMUNIZATION NEWS
"Dose-Related Effects of Smallpox Vaccine" New England Journal of Medicine (www.nejm.org) (04/25/02) Vol. 346, No. 17, P. 1275; Frey, Sharon E.; Newman, Frances K.; Cruz, John
To help researchers better understand the effects of smallpox vaccination, a study of 60 healthy adults was conducted involving three dilutions of vaccinia virus vaccine. The double-blind, randomized trial concentrated on the clinical success rates, humoral responses, and virus-specific activity of cytotoxic T cells and interferon-gamma-producing T cells. The three intradermal vaccinations were either an undiluted vaccine, a tenth of the original strength, or a hundredth of the undiluted medicine, each tested in 20 patients. Vaccinia vesicles appeared in 19 of the 20 full vaccine patients, 14 of the second group, and only three patients in the 1:100 dilution cohort. One month after vaccination, 34 of the 36 patients who developed vesicles showed antibody response to smallpox, compared to just one of the 24 patients who had no suggestion of virus replication. Cytotoxic T-cell and interferon-gamma responses were evident in 94 percent of vesicle patients, while a cytotoxic T-cell response was evident in only one non-vesicle patient. The study shows that vaccines made before 1982 are still potent in previously unvaccinated adults. ALL INFORMATION, DATA, AND
MATERIAL CONTAINED, PRESENTED, OR PROVIDED HERE IS FOR GENERAL INFORMATION
PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS REFLECTING THE KNOWLEDGE OR OPINIONS
OF THE PUBLISHER, AND IS NOT TO BE CONSTRUED OR INTENDED AS PROVIDING MEDICAL OR
LEGAL ADVICE. THE DECISION WHETHER OR NOT TO VACCINATE IS AN IMPORTANT AND
COMPLEX ISSUE AND SHOULD BE MADE BY YOU, AND YOU ALONE, IN CONSULTATION WITH
YOUR HEALTH CARE PROVIDER.
DISCLAIMER: All information, data, and material contained, presented, or provided here is for general information purposes only and is not to be construed as reflecting the knowledge or opinions of the publisher, and is not to be construed or intended as providing medical or legal advice. The decision whether or not to vaccinate is an important and complex issue and should be made by you, and you alone, in consultation with your health care provider.
Copyright 2012 by Vaccination News, A Non-Profit Corporation. All Rights Reserved. This content may not be copied unless permission in writing from Sandy Gottstein has been obtained. 
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 "A foolish faith in authority is the worst enemy of truth." -- Albert Einstein, letter to a friend, 1901 "I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education." -- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820 "What's the point of vaccination if it doesn't protect you from the unvaccinated?" -- Sandy Gottstein "Who gets to decide what the greater good is and how many will be sacrificed to it?" -- Sandy Gottstein |