http://bmj.com/cgi/content/full/324/7339/695/a
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Mammography helps to cut deaths from breast cancer in older women by about a third, agree experts assembled by the World Health Organization, hoping to put an end to the uncertainties that over the last two years have surrounded the value of screening.
The 24 experts from 11 countries, convened this month by the WHO's International Agency for Research on Cancer, dismissed the work of Danish investigators published in January 2000 and October 2001 that claimed that mammography did not save lives and could actually be harmful (Lancet 2000;355:129-34 and 2001;358:1340-2).
In women aged 50-69, mammography reduces the chances of dying from breast cancer by about 35% the group estimates, although in younger women there is only a slight benefit.
The Danish researchers, who are associated with the Cochrane Collaboration, had criticised the scientific basis of many of the major trials used worldwide to support national breast cancer screening programmes. But the WHO group, which re-examined the original studies, claims that the data do provide sufficient evidence that mammography saves lives in older women.
The National Institute for
Clinical Excellence has approved the use of the drug trastuzumab (Herceptin) in
combination with paclitaxel (Taxol) for women with advanced breast
cancer. Taxol has been available for use on its own for this group of
women for some time, but the new combination is expected to improve
survival rates in women with a particularly aggressive form of
breast cancer.
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