http://www.whale.to/v/meninguk.html

Vaccines  UK (BNF 42 2002) http://www.bnf.org/Index.htm  

BCG Vaccines:

Bacillus Calmette-Guérin Vaccine   BCG Vaccine, Dried Tub/Vac/BCG. A freeze-dried preparation of live bacteria of a strain derived from the bacillus of Calmette and Guérin.
Bacillus Calmette-Guérin Vaccine, Percutaneous Tub/Vac/BCG(Perc)    A preparation of live bacteria of a strain derived from the bacillus of Calmette and Guérin (important: this preparation must not be confused with the intradermal preparation)

Cholera vaccine

Cholera vaccine contains heat-killed Inaba and Ogawa sub-types of Vibrio cholerae, Serovar O1. Cholera vaccine provides little protection and cannot control the spread of the disease; it is no longer available in the UK.

Diphtheria vaccines  

Diphtheria vaccines for children  

With tetanus and pertussis (triple vaccine)  

Adsorbed Diphtheria, Tetanus, and Pertussis Vaccine DTPer/Vac/Ads    Injection, suspension of diphtheria formol toxoid, tetanus formol toxoid, and pertussis vaccine adsorbed on a mineral carrier Dose: primary immunisation of children, by intramuscular or deep subcutaneous injection, 0.5 mL at 2 months followed by second dose after 4 weeks and third dose after another 4 weeks (see schedule, section 14.1)Available from Health Authorities or (in England only) direct from Farillon as Aventis Pasteur MSD Ltd brand (excipients include thiomersal)

Infanrix ^® (Glaxo SmithKline) Injection, suspension of diphtheria toxoid, tetanus toxoid, and acellular pertussis vaccine components adsorbed on a mineral carrier, net price 0.5-mL prefilled syringe = £11.00

With tetanus  

Adsorbed Diphtheria and Tetanus Vaccine DT/Vac/Ads(Child)   Injection, suspension of diphtheria formol toxoid and tetanus formol toxoid adsorbed on a mineral carrier Dose: primary immunisation of children omitting pertussis component, by intramuscular or deep subcutaneous injection, 0.5 mL at 2 months followed by second dose after 4 weeks and third dose after another 4 weeks (see schedule, section 14.1); booster at school entry, 0.5 mL (see schedule, section 14.1) Available from Health Authorities or (in England only) direct from Farillon as Evans Vaccines brand (excipients include thiomersal) or Aventis Pasteur MSD Ltd brand (excipients include thiomersal)

With tetanus

DIFTAVAX Adsorbed Diphtheria Vaccine for Adults and Adolescents Dip/Vac/Ads(Adult)    Injection, diphtheria formol toxoid adsorbed on a mineral carriernet price 0.5-mL prefilled syringe = £2.67 Dose: primary immunisation in patients over 10 years, by intramuscular or deep subcutaneous injection, 3 doses each of 0.5 mL separated by intervals of 4 weeks; booster, 0.5 mL after 10 years Available from Health Authorities or (in England only) direct from Farillon as Aventis Pasteur MSD Ltd brand (Diftavax^®; excipients include thiomersal)

Single antigen  

Adsorbed Diphtheria Vaccine for Adults and Adolescents Dip/Vac/Ads(Adult)   Injection, diphtheria formol toxoid adsorbed on a mineral carrier Dose: primary immunisation in patients over 10 years, by intramuscular or deep subcutaneous injection, 3 doses each of 0.5 mL separated by intervals of 1 month; booster, 0.5 mL Booster in children under 10 years (when tetanus booster already given) [unlicensed use], see notes above Note. Unimmunised adults and children over 10 years who are contacts of a diphtheria case or carrier are given the primary immunisation course; immunised adults and children over 10 years are given the booster dose. Available from Health Authorities or (in England only) direct from Farillon

Diphtheria antitoxin

Diphtheria antitoxin is used for passive immunisation; it is prepared in horses therefore reactions are common after administration. It is now only used in suspected cases of diphtheria (without waiting for bacteriological confirmation); tests for hypersensitivity should be first carried out. It is no longer used for prophylaxis because of the risk of hypersensitivity; unimmunised contacts should be promptly investigated and given erythromycin prophylaxis (section 5.1, table 2) and vaccine (see notes above).

Diphtheria Antitoxin   Dip/Ser. Dose: prophylactic by intramuscular injection, 500–2000 units (but not used, see notes above); therapeutic 10 000–30 000 units increased to 40 000–100 000 units in severe cases; doses of up to 30 000 units should be given intramuscularly but for those over 40 000 units a portion is given intramuscularly followed by the bulk of the dose intravenously after an interval of ½–2 hours Note. Children require the same dose as adults, depending on the severity of the case. Available from Communicable Disease Surveillance Centre (Tel (020) 8200 6868) or in Northern Ireland from Public Health Laboratory, Belfast City Hospital (Tel (028) 9032 9241).

Haemophilus influenzae type B vaccine  

Single component  Each single component product may be used to complete a course started with any other single component product listed below

HibTITER ^® (Wyeth)  Injection, capsular polysaccharide of Haemophilus influenzae type b (conjugated to a protein carrier), net price 0.5-mL vial = £10.20

ACT-HIB ^® (Aventis Pasteur MSD Ltd)  Injection, powder for reconstitution, capsular polysaccharide of Haemophilus influenzae type b (conjugated to a protein carrier), net price per vial with diluent (0.5 mL) = £8.83

With diphtheria, tetanus and pertussis vaccines  Each combined product may be used to complete a course started with any other combined product listed below; important see also under Adsorbed Diphtheria, Tetanus and Pertussis Vaccine ( under DIPHTHERIA VACCINES)

ACT-HIB ^®DTP dc (Aventis Pasteur MSD Ltd) Injection, powder for reconstitution, capsular polysaccharide of Haemophilus influenzae type b (conjugated to a protein carrier) with diluent containing diphtheria toxoid, tetanus toxoid and Bordetella pertussis cells, net price per dual-chamber prefilled syringe = £10.41
Infanrix ^®-Hib (Glaxo SmithKline) Injection, powder for reconstitution, capsular polysaccharide of Haemophilus influenzae type b (conjugated to a protein carrier) with diluent containing diphtheria toxoid, tetanus toxoid, and acellular pertussis vaccine adsorbed on a mineral carrier, net price 0.5-mL vial = £19.00.

Hepatitis A

Single component:

Avaxim ^® (Aventis Pasteur MSD Ltd)  Injection, suspension of formaldehyde-inactivated hepatitis A virus (GBM grown in human diploid cells) 320 antigen units/mL adsorbed onto aluminium hydroxide, net price 0.5-mL prefilled syringe = £20.63

Havrix Monodose ^® (Glaxo SmithKline)  Injection, suspension of formaldehyde-inactivated hepatitis A virus (HM 175 grown in human diploid cells) 1440 ELISA units/mL adsorbed onto aluminium hydroxide, net price 1-mL prefilled syringe = £23.81, 0.5-mL (720 ELISA units) prefilled syringe (Havrix Junior Monodose^®) = £18.03
Vaqta ^® Adult (Aventis Pasteur MSD Ltd)  Injection, suspension of formaldehyde-inactivated hepatitis A virus (grown in human diploid cells) 50 antigen units/mL adsorbed onto aluminium hydroxide, net price 1-mL prefilled syringe = £20.63
Vaqta ^® Paediatric and Adolescent (Aventis Pasteur MSD Ltd)  Injection, suspension of formaldehyde-inactivated hepatitis A virus (grown in human diploid cells) 50 antigen units/mL adsorbed onto aluminium hydroxide, net price 0.5-mL prefilled syringe = £15.65

With hepatitis b:

Twinrix ^® (Glaxo SmithKline)  Injection, inactivated hepatitis A virus 720 ELISA units and recombinant (DNA) hepatitis B surface antigen 20 micrograms/mL adsorbed onto aluminium hydroxide and aluminium phosphate, net price 1-mL prefilled syringe (Twinrix^® Adult) = £29.85, 0.5-mL prefilled syringe (Twinrix^® Paediatric) = £22.36

With typhoid vaccine:

Hepatyrix ^® (Glaxo SmithKline) Injection, suspension of inactivated hepatitis A virus (grown in human diploid cells) 1440 ELISA units/mL adsorbed onto aluminium hydroxide, combined with typhoid vaccine containing 25 micrograms/mL virulence polysaccharide antigen of Salmonella typhi, net price 1-mL prefilled syringe = £34.49

Hepatitis b vaccine

Single component:

Engerix B ^® (Glaxo SmithKline)   Injection, suspension of hepatitis B surface antigen (rby, prepared from yeast cells by recombinant DNA technique) 20 micrograms/mL adsorbed onto aluminium hydroxide, net price 0.5-mL (paediatric) vial = £9.85, 1-mL vial = £13.27, 1-mL prefilled syringe = £13.97

H-B-Vax II   (Aventis Pasteur MSD Ltd)   Injection, suspension of hepatitis B surface antigen (prepared from yeast cells by recombinant DNA technique) 10 micrograms/mL adsorbed onto aluminium hydroxide, net price 1-mL prefilled syringe = £12.13, 1-mL vial = £11.41, 0.5-mL prefilled syringe (HB-Vax^® II Paediatric) = £8.99 Excipients: include thiomersal

With hepatitis A vaccine  See Hepatitis A Vaccine

Influenza vaccines:

Inactivated Influenza Vaccine (Split Virion) (Aventis Pasteur MSD Ltd)  Injection, suspension of formaldehyde-inactivated influenza virus (split virion) Flu/Vac/Split, net price 0.5-mL prefilled syringe = £5.70 Excipients: include thiomersal

Inactivated Influenza Vaccine (Surface Antigen) (Evans Vaccine)   Injection, suspension of propiolactone-inactivated influenza virus (surface antigen) Flu/Vac/SA, net price 0.5-mL prefilled syringe = £3.98   Excipients: include thiomersal

Begrivac ^® (Wyeth)  Injection, suspension of formaldehyde-inactivated influenza virus (split virion) Flu/Vac/Split, net price 0.5-mL prefilled syringe = £5.72

Fluarix ^® (Glaxo SmithKline)  Injection, suspension of formaldehyde-inactivated influenza virus (split virion) Flu/Vac/Split, net price 0.5-mL prefilled syringe = £3.99  Excipients: include thiomersal

Fluvirin ^® (Evans Vaccine)  Injection, suspension of propiolactone-inactivated influenza virus (surface antigen) Flu/Vac/SA, net price 0.5-mL prefilled syringe = £5.69Excipients: include thiomersal

Influvac Sub-unit ^® (Solvay Healthcare Ltd )  Injection, suspension of formaldehyde-inactivated influenza virus (surface antigen) Flu/Vac/SA, net price 0.5-mL prefilled syringe = £5.08  Excipients: include thiomersal Dose: by deep subcutaneous or by intramuscular injection, 0.5 mL as a single dose; CHILD 6–35 months 0.25–0.5 mL repeated after at least 4 weeks if child not previously infected or vaccinated

Measles vaccines:

Single antigen

Single antigen vaccine  No longer available in the UK

Combined vaccine:

MMR Vaccine  Live measles, mumps, and rubella vaccine Dose: by deep subcutaneous or by intramuscular injection, 0.5 mL Available from Health Authorities or (in England only) direct from Farillon as MMR II^® (Aventis Pasteur MSD Ltd) or Priorix^® (SmithKline Beecham)

Meningococcal vaccines 

Meningitec ® (Wyeth)  Injection, suspension of capsular polysaccharide antigen of Neisseria meningitidis group C (conjugated to Corynebacterium diphtheriae protein), net price 0.5-mL vial = £17.95

Menjugate ® (Chiron)  Injection, powder for reconstitution, capsular polysaccharide antigen of Neisseria meningitidis group C (conjugated to
Corynebacterium diphtheriae protein), adsorbed onto aluminium hydroxide, single-dose and 10-dose vials

NeisVac-C ® (Baxter)  Injection, suspension of polysaccharide antigen of Neisseria meningitidis group C (conjugated to tetanus toxoid protein), 0.5-mL prefilled syringe

AC Vax ® (Glaxo SmithKline)  Injection, powder for reconstitution, capsular polysaccharide antigens of Neisseria meningitidis groups A and C, net price single-dose vial (with diluent) = £7.37

Mengivac (A+C) ® (Aventis Pasteur MSD Ltd)  Injection, powder for reconstitution, capsular polysaccharide antigens of Neisseria meningitidis (meningococcus) groups A and C, net price single-dose vial (with syringe containing diluent) = £6.39

ACWY Vax ® (Glaxo SmithKline)  Injection, powder for reconstitution, capsular polysaccharide antigens of Neisseria meningitidis groups A, C, W135 and Y, net price single-dose vial (with diluent) = £17.14

pneumococcal vaccine:

Pneumococcal polysaccharide vaccines  

Pneumovax II    (Aventis Pasteur MSD Ltd)   Polysaccharide from each of 23 capsular types of pneumococcus, net price 0.5-mL prefilled syringe = £10.00 Dose: by subcutaneous or intramuscular injection, 0.5 mL; revaccination, see notes above; CHILD under 2 years, not recommended (suboptimal response and also safety and efficacy not established)

Pnu-Imune ^® (Wyeth)  Polysaccharide from each of 23 capsular types of pneumococcus, net price 0.5-mL vial = £9.94 Excipients: include thiomersal Dose: by subcutaneous or intramuscular injection, 0.5 mL; revaccination, see notes above; CHILD under 2 years, not recommended

Pneumococcal polysaccharide conjugated vaccine  

Prevnar ^® (Wyeth) Polysaccharide from each of 7 capsular types of pneumococcus adsorbed onto aluminium phosphate, net price 0.5-mL vial = £39.25 Dose: by intramuscular injection, INFANT under 6 months 3 doses each of 0.5 mL separated by intervals of 1 month and a further dose in second year of life; 6 months–1 year 2 doses each of 0.5 mL separated by an interval of 1 month and a further dose in second year of life; CHILD 1–2 years 2 doses each of 0.5 mL separated by an interval of 2 months

Polio vaccines

Live (oral) (Sabin)  

Poliomyelitis Vaccine, Live (Oral)    Pol/Vac (Oral)¹. A suspension of suitable live attenuated strains of poliomyelitis virus, types 1, 2, and 3. Available in single-dose and 10-dose containers Dose: 3 drops from a multidose container or the total contents of a single-dose container; for primary immunisation 3 doses are required (see schedule, section 14.1). May be given on a lump of sugar; not to be given with foods which contain preservatives Available from Health Authorities or (in England and Scotland only) direct from Farillon   1. BP permits code OPV for vaccine in single doses provided it also appears on pack. Note. Poliomyelitis vaccine loses potency once the container has been opened, therefore any vaccine remaining at the end of an immunisation session should be discarded; whenever possible sessions should be arranged to avoid undue wastage.

Inactivated (Salk)  

Poliomyelitis Vaccine, Inactivated    Pol/Vac (Inact). An inactivated suspension of suitable strains of poliomyelitis virus, types 1, 2, and 3. Dose: by subcutaneous injection, 0.5 mL or as stated on the label; for primary immunisation 3 doses are required at intervals of 4 weeks Available direct from Farillon. Note. Should be ordered one dose at a time (on a named-patient basis) and only when required for use

Rabies vaccine:

Rabies Vaccine (Aventis Pasteur MSD Ltd)  Freeze-dried inactivated Wistar rabies virus strain PM/WI 38 1503-3M cultivated in human diploid cells, net price single-dose vial with syringe containing diluent = £22.15 IMPORTANT. Studies have shown that when this vaccine is injected into the gluteal region there is a poor response. Concomitant administration of chloroquine may also affect the antibody response. Because of the potential consequences of inadequately treated rabies exposure and because there is no indication that fetal abnormalities have been associated with rabies vaccination, pregnancy is not considered a contra-indication to post-exposure prophylaxis. If there is substantial risk of exposure to rabies, pre-exposure prophylaxis may also be indicated during pregnancy

Rabipur ^® (MASTA)  Freeze-dried inactivated Flury LEP rabies virus strain cultivated in chick embryo cells, net price single-dose vial = £22.15 Dose: prophylactic, by intramuscular injection in the deltoid muscle or anterolateral thigh in small children, 1 mL on days 0, 7 and 21 or 28; also booster doses every 2–5 years for those at continued risk
Post-exposure, by intramuscular injection in the deltoid muscle or anterolateral thigh in small children, 1 mL, see notes above

Rubella vaccine:

Rubella Vaccine, Live   Rub/Vac (Live). Prepared from Wistar RA 27/3 strain propagated in human diploid cells Dose: by deep subcutaneous or by intramuscular injection, 0.5 mL (see schedule, section 14.1 and notes above) Available from Health Authorities or (in England only) direct from Farillon as SmithKline Beecham brand (Ervevax^®)

Tetanus vaccines:

Adsorbed Tetanus Vaccine   Tet/Vac/Ads. Injection, suspension of tetanus formol toxoid adsorbed on a mineral carrier Dose: by deep subcutaneous or by intramuscular injection, 3 doses each of 0.5 mL separated by intervals of 1 month Available from Evans Vaccines as Clostet^®, net price 0.5-mL single-dose syringe = £1.40) and from Aventis Pasteur MSD Ltd Aventis Pasteur (net price 0.5-mL amp = 74p; 0.5-mL single-dose syringe = £1.50; excipients include thiomersal

Typhoid vaccines:

Polysaccharide vaccine for injection  

Typherix ^® (Glaxo SmithKline)  Injection, Vi capsular polysaccharide typhoid vaccine, 50 micrograms/mL virulence polysaccharide antigen of Salmonella typhi, net price 0.5-mL prefilled syringe = £10.68 Dose: by intramuscular injection, 0.5 mL; CHILD under 2 years may show suboptimal response

Typhim Vi ^® (Aventis Pasteur MSD Ltd )  Injection, Vi capsular polysaccharide typhoid vaccine, 50 micrograms/mL virulence polysaccharide antigen of Salmonella typhi, net price 0.5-mL prefilled syringe = £10.20 Dose: by deep subcutaneous or by intramuscular injection, 0.5 mL; CHILD under 18 months may show suboptimal response

Polysaccharide vaccine with hepatitis A vaccine  See Hepatitis A Vaccine

Live oral vaccine  

Vivotif ^® (MASTA)   Capsules, e /c, live attenuated Salmonella typhi (Ty 21a), net price 3-cap pack = £15.88. Label: 23, 25, C, administration dose: ADULT and CHILD over 6 years, 1 capsule on days 1, 3, and 5; under 6 years, not recommended COUNSELLING. Swallow as soon as possible after placing in mouth with a cold or lukewarm drink; it is important to store capsules in refrigerator

Yellow Fever Vaccine

Yellow Fever Vaccine, Live   Yel/Vac. A suspension of chick embryo proteins containing attenuated 17D strain virusDose: by subcutaneous injection, 0.5 mL   Available (only to designated Yellow Fever Vaccination centres) as Arilvax^® (Evans Vaccine)

ALL INFORMATION, DATA, AND MATERIAL CONTAINED, PRESENTED, OR PROVIDED HERE IS FOR GENERAL INFORMATION PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS REFLECTING THE KNOWLEDGE OR OPINIONS OF THE PUBLISHER, AND IS NOT TO BE CONSTRUED OR INTENDED AS PROVIDING MEDICAL OR LEGAL ADVICE.  THE DECISION WHETHER OR NOT TO VACCINATE IS AN IMPORTANT AND COMPLEX ISSUE AND SHOULD BE MADE BY YOU, AND YOU ALONE, IN CONSULTATION WITH YOUR HEALTH CARE PROVIDER.