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Gastroenterology 1999 Apr;116(4):796-803 |
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Comment in:
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Gastroenterology. 1999 Apr;116(4):988-90
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Gastroenterology.
1999 Nov;117(5):1253-5.
Paramyxovirus infections in childhood and
subsequent inflammatory bowel disease.
Montgomery SM, Morris DL, Pounder RE, Wakefield AJ.
Inflammatory Bowel Disease Study Group, Department of Medicine, Royal Free and
University College Medical School, London, England. smm@rfhsm.ac.uk
BACKGROUND & AIMS: Measles virus has been implicated in the etiology of
both inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative
colitis. Subacute sclerosing panencephalitis (SSPE) is caused by atypical
measles infection. This study investigated the patterns of infection that are
risks for SSPE, early infection and a close temporal relationship between
measles and another infection, as potential risks for IBD. METHODS: The data
are from 7019 members of a nationally representative 1970 British Cohort Study.
The ages of five childhood infections were recorded before onset of IBD
symptoms. Diagnoses of IBD and insulin-dependent diabetes mellitus (IDDM), as a
control disease, were identified by age 26 years. RESULTS: Mumps infection
before age 2 years was a risk for ulcerative colitis (odds ratio, 25.12; 95%
confidence interval, 6. 35-99.36). Measles and mumps infections in the same
year of life were significantly associated with ulcerative colitis and Crohn's
disease, with odds ratios of 7.47 (2.42-23.06) and 4.27 (1.24-14.46), but not
with IDDM. These relationships are independent of each other as well as sex,
social class at birth, household crowding in childhood, and family history of
IBD. CONCLUSIONS: Atypical paramyxovirus infections in childhood may be risk
factors for later IBD.
PMID: 10092301 [PubMed - indexed for MEDLINE]
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