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Nervous system disease & vaccination
Vaccine
diseases Citations
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Neurological Demyelination CENTRAL NERVOUS SYSTEM (CNS) Brain & spinal cord Acute Flaccid paralysis Encephalomyelitis Multiple Sclerosis/MS Polio Brain (Encephalopathy) Encephalopathy Meningitis Meningoencephalitis Parkinsonism Encephalitis Epilepsy Spinal cord Transverse myelitis /radiculomyelitis/myelitis CFIDS/ME (formerly myalgic encephalomyelitis) |
PERIPHERAL NERVOUS SYSTEM Neuropathy/Neuritis/Polyradiculitis/polyradiculopathy Inflammatory polyradiculoneuropathy Guillain-Barre syndrome/polyneuropathy Chronic inflammatory Demylenating Polyneuropathy (CIDP) Related: Hiding polio
Mononeuropathy (single nerve) demyelinating polyneuropathy
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Dyro FM. Vaccination mononeuropathy.Ann Neurol. 1978 May;3(5):468. No abstract available.PMID: 215078 [PubMed - indexed for MEDLINE]
Maillefert JF, Farge P, Gazet-Maillefert MP, Tavernier C.
Mental nerve neuropathy as a result of hepatitis B vaccination.Oral
Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Jun;83(6):663-4.PMID: 9195619
[PubMed - indexed for MEDLINE]
Powell HC, Mizisin AP, Wiley CA, Morey MK, Hughes RA.
Relationship of adjuvants and swine influenza vaccine to experimental neuropathy
in rabbits.Acta Neuropathol (Berl). 1987;73(1):12-8.PMID:
3037840 [PubMed - indexed for MEDLINE]
Experimental neuropathy, characterized by endoneurial edema and demyelination,
was induced by inoculating rabbits with a combination of Freund's
complete adjuvant (FCA), gangliosides, lecithin and cholesterol. A less
severe demyelinating neuropathy could be induced by treatment with FCA alone but
no significant change could be elicited by injection of swine influenza vaccine
(SFV) alone. When FCA was combined with gangliosides, lecithins, cholesterol and
SFV, neuropathy occurred, but the changes were less severe than if these agents
were used without SFV. Sera were tested for myelin basic protein (MBP) and
galactocerebroside (GC) antibodies in each experimental group. Neither SFV alone
nor SFV combined with Freund's complete adjuvant, gangliosides, cholesterol and
lecithin evoked significant antibody titers to MBP or GC. However, rabbits
inoculated with FCA, gangliosides, lecithin and cholesterol had rising titers of
antibody to both MBP and GC over the 3-month experimental period. One rabbit
inoculated with FCA alone had significant antibody to MBP. The findings suggest
that Freund's complete adjuvant alone can induce demyelination in the peripheral
nerves of rabbits and that SFV may modulate the immune response acting either as
an adjuvant or suppressant in the experimental demyelinating disease.
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