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Methotrexate
Drug adverse reactions citations

Blackburn WD Jr, Alarcon GS. Impotence in three rheumatoid arthritis patients treated with methotrexate.Arthritis Rheum. 1989 Oct;32(10):1341-2. No abstract available.PMID: 2803334 [PubMed - indexed for MEDLINE]

Combe B, Sany J.  Extraarticular manifestations during methotrexate therapy for rheumatoid arthritis.J Rheumatol. 1995 Apr;22(4):790. No abstract available.PMID: 7791187 [PubMed - indexed for MEDLINE]

Dubin Kerr L, Troy K, Isola L.Temporal association between the use of methotrexate and development of leukemia in 2 patients with rheumatoid arthritis.J Rheumatol. 1995 Dec;22(12):2356-8.PMID: 8835576 [PubMed - indexed for MEDLINE]

Ellman MH, Hurwitz H, Thomas C, Kozloff M.  Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate.J Rheumatol. 1991 Nov;18(11):1741-3.PMID: 1787499 [PubMed - indexed for MEDLINE]

Finger DR, Klipple GL.  Gynecomastia following low dose methotrexate therapy for rheumatoid arthritis.J Rheumatol. 1995 Apr;22(4):796-7. No abstract available.PMID: 7791195 [PubMed - indexed for MEDLINE]

Grisold W, Lutz D, Wolf D. Necrotizing myelopathy associated with acute lymphoblastic leukemia. Case report and review of literature. Acta Neuropathol (Berl). 1980;49(3):231-5. PMID: 6929156 [PubMed - indexed for MEDLINE]
The clinico-pathological findings are reported of a 16-year-old boy with acute lymphoblastic leukemia who during chemotherapy which included intrathecal Methotrexate developed a transverse cord lesion 5 months before death. Autopsy revealed necrotizing myelopathy of the T8--T10 segments and moderate lymphoblastic infiltration of the cerebrospinal meninges and spinal nerve roots. Neither parenchymal infiltration nor vascular lesions were found. The pathogenesis of this rare lesion associated with acute lymphoblastic leukemia remains obscure.

Grardel B, Fauquert P, Hardouin P. Malignancy in patients with rheumatoid arthritis treated with methotrexate.J Rheumatol. 1997 Apr;24(4):805-6; discussion 806-7. No abstract available.PMID: 9101525 [PubMed - indexed for MEDLINE]

Iqbal MP, Ali AA, Alvi AA [corrected to Ali AA].  Severe bone marrow suppression in a patient with rheumatoid arthritis on methotrexate.J Pak Med Assoc. 1993 Dec;43(12):262-3. No abstract available.PMID: 8133640 [PubMed - indexed for MEDLINE]

Kolte B, Baer AN, Sait SN, O'Loughlin KL, Stewart CC, Barcos M, Wetzler M, Baer MR.   Acute myeloid leukemia in the setting of low dose weekly methotrexate therapy for rheumatoid arthritis.Leuk Lymphoma. 2001 Jul;42(3):371-8.PMID: 11699401 [PubMed - indexed for MEDLINE]

Kevat SG, Hill WR, McCarthy PJ, Ahern MJ.  Pancytopenia induced by low-dose methotrexate for rheumatoid arthritis.Aust N Z J Med. 1988 Aug;18(5):697-700.PMID: 3245825 [PubMed - indexed for MEDLINE]

Laroche F, Perrot S, Menkes CJ.Pancytopenia in rheumatoid arthritis patients receiving methotrexate.Rev Rhum Engl Ed. 1996 May;63(5):381-2. No abstract available.PMID: 8789889 [PubMed - indexed for MEDLINE]

Marce S, Bannwarth B, Schaeverbeke T, Dehais J.[Neutropenia after the first administration of methotrexate in rheumatoid arthritis]Rev Rhum Ed Fr. 1993 Nov 30;60(11):843-4. French. No abstract available.PMID: 8054935 [PubMed - indexed for MEDLINE]

Mueller S, Bell W, Seibert J.Cerebral calcifications associated with intrathecal methotrexate therapy in acute lymphocytic leukemia.J Pediatr. 1976 Apr;88(4 Pt. 1):650-3. No abstract available.PMID: 1062546 [PubMed - indexed for MEDLINE]

Omdal R, Goransson L, Bergrem H.Fatal outcome of low-dose methotrexate therapy in rheumatoid arthritis.Clin Rheumatol. 1993 Jun;12(2):283-4. No abstract available.PMID: 8358998 [PubMed - indexed for MEDLINE]

Pointud P, Prudat M, Peron JM.Acute leukemia after low dose methotrexate therapy in a patient with rheumatoid arthritis.J Rheumatol. 1993 Jul;20(7):1215-6.PMID: 8371222 [PubMed - indexed for MEDLINE]

Reznik M. Acute ascending poliomyelomalacia after treatment of acute lymphocytic leukemia.Acta Neuropathol (Berl). 1979 Feb 15;45(2):153-7.PMID: 283679 [PubMed - indexed for MEDLINE]

This paper reports the case of a 16-year-old girl with acute lymphoblastic leukemia who received chemotherapy including intrathecal injections of methotrexate and preventive irradiation of the brain, but not of the spinal cord. Several months later, she died from an acute ascending poliomyelitic syndrome hrolving during 10 days. Clinical, bacteriological, and viral investigations failed to demonstrate any pathological agent. Autopsy revealed an acute ischemic lesion involving both anterior horns of the whole spinal cord and extending from the lower segment up to the mesencephalic region, without significant alteration of the white matter. Neither tumoral invasion, nor vascular obstruction was found. The pathogenesis of this yet undescribed lesion remained unclear but a metabolic disorder seemed the most plausible pathological factor.

Stewart M, Malkovska V, Krishnan J, Lessin L, Barth W.  Lymphoma in a patient with rheumatoid arthritis receiving methotrexate treatment: successful treatment with rituximab.Ann Rheum Dis. 2001 Sep;60(9):892-3.

Sukenik S, Ariad S, Flusser D.  Malignancy in patients with rheumatoid arthritis treated with methotrexate.J Rheumatol. 1997 Apr;24(4):806; discussion 806-7. No abstract available.PMID: 9101526 [PubMed - indexed for MEDLINE]

Thomas E, Leroux JL, Blotman F.Gynecomastia in patients with rheumatoid arthritis treated with methotrexate.J Rheumatol. 1994 Sep;21(9):1777-8. No abstract available.PMID: 7799373 [PubMed - indexed for MEDLINE]

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