http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11513549&dopt=Abstract
Infection of human B lymphocytes with MMR vaccine induces IgE
class switching.
Imani F, Kehoe KE.
Division of Clinical Immunology, Department of Medicine, The Johns Hopkins
University School of Medicine, Asthma and Allergy Center, 5501 Hopkins Bayview
Circle, Baltimore, Maryland 21224, USA. fimani@mail.jhmi.edu
Circulating immunoglobulin E (IgE) is one of the characteristics of human
allergic diseases including allergic asthma. We recently showed that infection
of human B cells with rhinovirus or measles virus could lead to the initial
steps of IgE class switching. Since many viral vaccines are live viruses, we
speculated that live virus vaccines may also induce IgE class switching in human
B cells. To examine this possibility, we selected the commonly used live
attenuated measles mumps rubella (MMR) vaccine. Here, we show that infection of
a human IgM(+) B cell line with MMR resulted in the expression of germline
epsilon transcript. In addition, infection of freshly prepared human PBLs with
this vaccine resulted in the expression of mature IgE mRNA transcript.
Our data suggest that a potential side
effect of vaccination with live attenuated viruses may be an increase in the
expression of IgE.
Copyright 2001 Academic Press.
PMID: 11513549 [PubMed - indexed for MEDLINE]
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