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Journal Home Page Clinical Immunology
Vol. 100, No. 3, September 1, 2001
ISSN: 1521-6616
EISSN: 1090-2341
 
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Infection of Human B Lymphocytes with MMR Vaccine Induces IgE Class Switching
pp. 355-361 (doi:10.1006/clim.2001.5073) 
Farhad Imani1,  Kelly E. Kehoe  

Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, Maryland, 21224
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  • Imani, F [IDEAL] 
  • Kehoe, KE [IDEAL] 
    		•
    (Received February 26, 2001; accepted May 24, 2001; published electronically July 26, 2001)
    Abstract

    Circulating immunoglobulin E (IgE) is one of the characteristics of human allergic diseases including allergic asthma. We recently showed that infection of human B cells with rhinovirus or measles virus could lead to the initial steps of IgE class switching. Since many viral vaccines are live viruses, we speculated that live virus vaccines may also induce IgE class switching in human B cells. To examine this possibility, we selected the commonly used live attenuated measles mumps rubella (MMR) vaccine. Here, we show that infection of a human IgM+ B cell line with MMR resulted in the expression of germline [epsilon] transcript. In addition, infection of freshly prepared human PBLs with this vaccine resulted in the expression of mature IgE mRNA transcript. Our data suggest that a potential side effect of vaccination with live attenuated viruses may be an increase in the expression of IgE. Copyright 2001 Academic Press.


    Key Words:  vaccine; IgE; asthma; allergy

     
    1To whom correspondence should be addressed. E-mail: fimani@mail.jhmi.edu.

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