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Infectious disease experimentation involving human
volunteers.
Rosenbaum JR, Sepkowitz KA.
Department of Internal Medicine, Robert Wood Johnson Clinical Scholars Program,
Yale University School of Medicine, New Haven, CT, 06510, USA. Julie.rosenbaum@yale.edu
The current care of patients with infectious diseases owes a tremendous debt to
healthy volunteers who allowed investigators to induce disease in them for the
study of transmission, natural history, and treatment. We reviewed the
English-language medical literature about the rarely discussed subject of the
use of healthy volunteers in human-subject research in infectious diseases to
determine the contributions of these experiments to the current understanding of
disease transmission. The literature review focused on hepatitis, upper
respiratory infections, and malaria, which represent the array of issues
involved in this type of research. Researchers successfully induced infection
through injecting, nebulizing, and feeding specimens to thousands of volunteers,
who included authentic volunteers as well as soldiers and imprisoned subjects.
These volunteers often undertook unforeseen and unpredictable risks during these
experiments for the benefit of others. Future research in these areas must
strike an adequate balance between the risks to participants and the benefits to
society.
PMID: 11880963 [PubMed - in process]
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