Drug induced aseptic meningitis (DIAM) citations

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Drug induced aseptic meningitis (DIAM) citations
DIAM Meningitis Vaccine meningitis

Antibiotics:
Antibiotic & vaccine associated paralytic Poliomyelitis (VAPP)

[Media UK, 1996] Meningitis clusters linked to antibiotics (erythromycin)

Andrade A, Hilmas E, Walter C. A rare occurrence of trimethoprim/sulfamethoxazole (TMP/SMX)-induced aseptic meningitis in an older woman.J Am Geriatr Soc. 2000 Nov;48(11):1537-8. No abstract available.PMID: 11083344 [PubMed - indexed for MEDLINE]

Capra C, Monza GM, Meazza G, Ramella G. Trimethoprim-sulfamethoxazole-induced aseptic meningitis: case report and literature review.Intensive Care Med. 2000 Feb;26(2):212-4. Review.PMID: 10784311 [PubMed - indexed for MEDLINE]

Corson AP, Chretien JH. Metronidazole-associated aseptic meningitis.Clin Infect Dis. 1994 Nov;19(5):974. No abstract available.PMID: 7893894 [PubMed - indexed for MEDLINE]

Czerwenka W, Gruenwald C, Conen D. Aseptic meningitis after treatment with amoxicillin.BMJ. 1999 Jun 5;318(7197):1521. No abstract available.PMID: 10356006 [PubMed - indexed for MEDLINE]

Czerwenka WM. Amoxicillin can induce aseptic meningitis.Arch Intern Med. 1999 Dec 13-27;159(22):2746. No abstract available.PMID: 10597768 [PubMed - indexed for MEDLINE]

Jacobsson G, Elowson S. [Amoxicillin caused aseptic meningoencephalitis]Lakartidningen. 1999 Jan 20;96(3):201-2. Swedish. No abstract available.PMID: 10068320 [PubMed - indexed for MEDLINE]

Wittmann A, Wooten GF. Amoxicillin-induced aseptic meningitis.Neurology. 2001 Nov 13;57(9):1734. No abstract available.PMID: 11706130 [PubMed - indexed for MEDLINE]

Alloway JA, Mitchell SR. Sulfasalazine neurotoxicity: a report of aseptic meningitis and a review of the literature.J Rheumatol. 1993 Feb;20(2):409-11. Review. No abstract available.PMID: 8097252 [PubMed - indexed for MEDLINE]

Barbot F, Danan-Causanski S, Chaouat D, Thuong M.[Aseptic meningitis after ranitidine treatment for systemic lupus erythematosus]Presse Med. 1999 Nov 13;28(35):1938. French. No abstract available.PMID: 10598151 [PubMed - indexed for MEDLINE]

Ballas ZK, Donta ST. Sulindac-induced aseptic meningitis.Arch Intern Med. 1982 Jan;142(1):165-6.PMID: 7053720 [PubMed - indexed for MEDLINE]

Bouland DL, Specht NL, Hegstad DR. Ibuprofen and aseptic meningitis.Ann Intern Med. 1986 May;104(5):731. No abstract available.PMID: 3963677 [PubMed - indexed for MEDLINE]

Chaudhry HJ, Cunha BA. Drug-induced aseptic meningitis. Diagnosis leads to quick resolution. Postgrad Med. 1991 Nov 15;90(7):65-70. Review. PMID: 1946120 [PubMed - indexed for MEDLINE]

Giansiracusa DF, Blumberg S, Kantrowitz FG. Aseptic meningitis associated with ibuprofen.Arch Intern Med. 1980 Nov;140(11):1553. No abstract available.PMID: 7436656 [PubMed - indexed for MEDLINE]

Greenberg GN.Recurrent sulindac-induced aseptic meningitis in a patient tolerant to other nonsteroidal anti-inflammatory drugs.
South Med J. 1988 Nov;81(11):1463-4.PMID: 3187641 [PubMed - indexed for MEDLINE]

Horn AC, Jarrett SW. Ibuprofen-induced aseptic meningitis in rheumatoid arthritis. Ann Pharmacother. 1997 Sep;31(9):1009-11. PMID: 9296242 [PubMed - indexed for MEDLINE]
OBJECTIVE: To report a case of aseptic meningitis related to ibuprofen ingestion. CASE SUMMARY: We discuss the case of a 56-year-old white man with a history of rheumatoid arthritis and hypertension who became confused, nauseated, and began to vomit within 2 hours of the ingestion of ibuprofen. A diagnosis of ibuprofen-induced aseptic meningitis was made based on the patient's physical and laboratory findings, the quick onset and resolution of symptoms, and his medical history. DISCUSSION: Ibuprofen-induced aseptic meningitis has been most frequently reported in patients with systemic lupus erythematosus. However, there have been reports of this reaction in patients with other underlying disease states. Various nonsteroidal antiinflammatory drugs have been reported to cause this reaction, but ibuprofen is the most common offending agent. A drug-related cause should be considered in any patient who presents with typical meningitis symptoms, such as fever, headache, and stiff neck, that occur within hours of ingesting a drug. CONCLUSIONS: Although persons with systemic lupus erythematosus appear to have an increased risk for this type of reaction, the development of signs and symptoms in other patients warrants the consideration of nonsteroidal antiinflammatory drugs as the cause of aseptic meningitis.

Hanson L. Ibuprofen-induced aseptic meningitis. J Tenn Med Assoc. 1994 Feb;87(2):58. No abstract available. PMID: 8176914 [PubMed - indexed for MEDLINE]

Herlihy TE. Phenazopyridine and aseptic meningitis. Ann Intern Med. 1987 Jan;106(1):172-3. No abstract available. PMID: 3789573 [PubMed - indexed for MEDLINE]

Hanson L. Ibuprofen-induced aseptic meningitis.J Tenn Med Assoc. 1994 Feb;87(2):58. No abstract available.PMID: 8176914 [PubMed - indexed for MEDLINE]

Hoppmann RA, Peden JG, Ober SK. Central nervous system side effects of nonsteroidal anti-inflammatory drugs. Aseptic meningitis, psychosis, and cognitive dysfunction.Arch Intern Med. 1991 Jul;151(7):1309-13. Review.PMID: 2064481 [PubMed - indexed for MEDLINE]

Jolles S, Sewell WA, Leighton C. Drug-induced aseptic meningitis: diagnosis and management. Drug Saf. 2000 Mar;22(3):215-26. Review.PMID: 10738845 [PubMed - indexed for MEDLINE]
Drug-induced aseptic meningitis (DIAM) has been reported as an uncommon adverse reaction with numerous agents. It is a diagnosis of exclusion, and clinical signs and CSF findings vary greatly. The body of evidence regarding DIAM is largely in the form of anecdotal case reports and must be interpreted carefully bearing this in mind. The major categories of causative agents are nonsteroidal anti-inflammatory drugs, antimicrobials, intravenous immunoglobulin, intrathecal agents, vaccines and a number of other less frequently reported agents. There appears to be an association between DIAM and connective tissue disease, particularly systemic lupus erythematosus, and ibuprofen. There are 2 major proposed mechanisms for DIAM. The first involves direct irritation of the meninges by intrathecal administration of the drug, and the second involves immunological hypersensitivity to the drug, most likely type III and type IV hypersensitivity. Recognition and diagnosis of DIAM is important, as it is treatable by withdrawal of the drug and recurrence is prevented. The outcome of DIAM is generally good, usually without long term sequelae. This article describes the case reports of DIAM in the current literature and discusses the diagnosis and management of this rare complication.

Kindmark CO, Carlsson U, Hedback B, Tove H. [Aseptic meningitis after treatment with ibuprofen]Lakartidningen. 1987 Sep 2;84(36):2782-3. Swedish. No abstract available.PMID: 3669815 [PubMed - indexed for MEDLINE]

Lafferty TE, DeHoratius RJ, Smith JB.Aseptic meningitis as a side effect of intravenous immune gammaglobulin.J Rheumatol. 1997 Dec;24(12):2491-2. No abstract available.PMID: 9415672 [PubMed - indexed for MEDLINE]

Lawson JM, Grady MJ. Ibuprofen-induced aseptic meningitis in a previously healthy patient. West J Med. 1985 Sep;143(3):386-7. No abstract available. PMID: 4049858 [PubMed - indexed for MEDLINE]

Marinac JS. Drug- and chemical-induced aseptic meningitis: a review of the literature. Ann Pharmacother. 1992 Jun;26(6):813-22. Review. PMID: 1611165 [PubMed - indexed for MEDLINE]
OBJECTIVE: The primary objective of this article is to provide readers with case reports of drug- or chemical-induced aseptic meningitis (DCAM) described in the medical literature. Background information regarding the classification of DCAM, incidence, proposed mechanisms, associated risk factors, clinical management, and sequelae is presented. DATA SOURCES: A MEDLINE search was used to identify pertinent background literature and case reports of DCAM. DATA EXTRACTION: All case reports of DCAM involve anecdotal information. A critical analysis of a causal relationship to the implicated drug or chemical and the appearance of meningeal involvement is presented. Animal data are included when pertinent. DATA SYNTHESIS: DCAM is a rare adverse event associated with numerous agents. Patients present with a variety of clinical signs and symptoms and laboratory findings of cerebral spinal fluid, when obtained, vary greatly. Most patients fully recover without sequelae. CONCLUSIONS: Numerous drugs and chemicals have been implicated in the medical literature as producing DCAM. Two proposed mechanisms of DCAM have been theorized: a delayed hypersensitivity-type reaction and direct meningeal irritation. The nonsteroidal antiinflammatory drugs, certain antibiotics, radiographic agents, and muromonab-CD3 have been most frequently implicated. There appears to be an association between the occurrence of the hypersensitivity-type reactions and underlying collagen vascular or rheumatologic disease.

Moris G, Garcia-Monco JC. The challenge of drug-induced aseptic meningitis. Arch Intern Med. 1999 Jun 14;159(11):1185-94. Review. PMID: 10371226 [PubMed - indexed for MEDLINE]
Several drugs can induce the development of aseptic meningitis. Drug-induced aseptic meningitis (DIAM) can mimic an infectious process as well as meningitides that are secondary to systemic disorders for which these drugs are used. Thus, DIAM constitutes a diagnostic and patient management challenge. Cases of DIAM were reviewed through a MEDLINE literature search (up to June 1998) to identify possible clinical and laboratory characteristics that would be helpful in distinguishing DIAM from other forms of meningitis or in identifying a specific drug as the culprit of DIAM. Our review showed that nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, intravenous immunoglobulins, and OKT3 antibodies (monoclonal antibodies against the T3 receptor) are the most frequent cause of DIAM. Resolution occurs several days after drug discontinuation and the clinical and cerebrospinal fluid profile (neutrophilic pleocytosis) do not allow DIAM to be distinguished from infectious meningitis. Nor are there any specific characteristics associated with a specific drug. Systemic lupus erythematosus seems to predispose to NSAID-related meningitis. We conclude that a thorough history on prior drug intake must be conducted in every case of meningitis, with special focus on those aforementioned drugs. If there is a suspicion of DIAM, a third-generation cephalosporin seems a reasonable treatment option until cerebrospinal fluid cultures are available.

Maignen F, Castot A, Falcy M, Efthymiou ML. [Drug-induced aseptic meningitis]Therapie. 1992 Sep-Oct;47(5):399-402. Review. French.PMID: 1299979 [PubMed - indexed for MEDLINE]
Aseptic meningitis is a very rare drug reaction involving non-steroidal antiinflammatory agents (ibuprofen and sulindac), antibiotics (cotrimoxazole, trimethoprim, ciprofloxacin) and miscellaneous drugs such as carbamazepine, human immune globulin and muromonab CD3. Meningeal symptoms occur a few hours after drug intake and resolve without sequelae within one or two days after drug withdrawal, mainly in young females with systemic lupus erythematosus or mixed connective tissue disease. Biological findings and radiological investigations are not suggestive of an infectious etiology or rheumatological/neurological disturbances. Diagnosis is simple when recurrent episodes coincide with drug ingestion.

Oddou S, Molinier S, Coso D, Boulet JM, Gastaut JA, Bouabdallah R. [Aseptic meningitis following treatment with immunoglobulins: physiopathological and prognostic value of screening]Presse Med. 1995 May 27;24(19):916. French. No abstract available.PMID: 7638138 [PubMed - indexed for MEDLINE]

Pisani E, Fattorello C, Leotta MR, Marcello O, Zuliani C. Recurrence of ibuprofen-induced aseptic meningitis in an otherwise healthy patient.Ital J Neurol Sci. 1999 Feb;20(1):59-62.PMID: 10933487 [PubMed - indexed for MEDLINE]

Preminger-Shapiro R, Nussinovitch M, Soen G, Varsano I. Aseptic meningitis: a frequent side-effect of intravenous immunoglobulin?Eur J Pediatr. 1995 Oct;154(10):866-7. No abstract available.PMID: 8529693 [PubMed - indexed for MEDLINE]

Roel JE, Gadano AC, Falcon JL. [Ketoprofen and aseptic meningitis] Medicina (B Aires). 1991;51(2):186. Spanish. No abstract available. PMID: 1820511 [PubMed - indexed for MEDLINE]

Rottach K, Scheglmann K, Pfadenhauer K. Mollaret's meningitis: a new aetiologic feature.Eur Neurol. 1996;36(3):172-3. No abstract available.PMID: 8738949 [PubMed - indexed for MEDLINE]

Ruppert GB, Barth WF. Tolmetin-induced aseptic meningitis.JAMA. 1981 Jan 2;245(1):67-8.PMID: 7431632 [PubMed - indexed for MEDLINE]

Sirvent N, Monpoux F, Benet L, Mariani R. [Aseptic meningitis during treatment with immunoglobulins] Arch Pediatr. 1996 Aug;3(8):830-1. French. No abstract available. PMID: 8998543 [PubMed - indexed for MEDLINE]

Seaton RA, France AJ. Recurrent aseptic meningitis following non- steroidal anti-inflammatory drugs--a reminder.Postgrad Med J. 1999 Dec;75(890):771-2.PMID: 10567617 [PubMed - indexed for MEDLINE]

Scribner CL, Kapit RM, Phillips ET, Rickles NM. Aseptic meningitis and intravenous immunoglobulin therapy.Ann Intern Med. 1994 Aug 15;121(4):305-6. No abstract available.PMID: 8037414 [PubMed - indexed for MEDLINE]

Weksler BB, Lehany AM. Naproxen-induced recurrent aseptic meningitis.DICP. 1991 Nov;25(11):1183-4.PMID: 1763533 [PubMed - indexed for MEDLINE]

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