Preventive Smallpox Vaccinations Urged for Health Workers
By
LAWRENCE K. ALTMAN
mallpox
vaccine should be made available to certain groups of health care
workers like those in emergency rooms even before a bioterrorist
attack, a number of speakers said yesterday at a forum on
vaccination policy.
The speakers, at a government-sponsored forum at the Mount Sinai
Medical Center in Manhattan, many of whom were doctors, nurses and
other health care workers, said they needed protection because, if
an attack occurred, they would most likely be the first to care for
patients.
The forum was the first in a national series that the Centers for
Disease Control and Prevention is holding to solicit opinions before
two advisory committees decide whether to change recommendations on
smallpox vaccination because of the bioterrorism threat and the
availability of additional vaccine.
The current recommendation is that vaccine be given just to the
small number of scientists and laboratory workers who work with
smallpox and closely related viruses. The advisory panels are
considering whether changes are needed, in particular whether the
entire population should be vaccinated or just health care and other
emergency workers.
The panels, the Advisory Committee on Immunization Practices and
the National Vaccine Advisory Committee, are generally expected to
make their decision by June 20.
The fairness of offering vaccine to one group and not to the
population at large is an issue that the panels will consider before
their decision, a spokesman for disease control centers, Glen Nowak,
said. The committees will be guided by standard public health
policy, which calls for weighing the benefits of vaccinating a
specific group, or the general public, against the risk of
complications. Determining the balance is particularly difficult
because the disease would not be naturally transmitted, and the
benefit is to protect against a theoretical risk, a bioterrorist
attack.
One factor is that health care workers would most likely have a
greater risk of exposure to smallpox than the average citizen. In
deciding, the panels will want to avoid putting any group, or the
public at large, at unnecessary risk, Dr. Nowak said.
At the New York forum, few speakers said they favored vaccinating
the public because of the risks of the vaccine. The vaccine is
probably the most dangerous one. It can cause serious problems like
generalized rashes, brain damage and death. It poses risks to
vaccinated people and to those with whom they come in contact.
As many as 38 million Americans would be at serious risk of
complications from smallpox vaccine because they are infected with
H.I.V., have cancer or other diseases causing impaired immune
systems or have or have had common skin conditions like eczema and
atopic dermatitis.
"We heard a great diversity of views," Dr. Guthrie S. Birkhead, a
New York State health official and a member of the committees, said
in summarizing the forum.
The committees are basing their thinking on the assumption that
the government has not learned of a specific new threat, Dr.
Birkhead said. But a broader recommendation would take effect if
laboratory workers identified the virus or doctors diagnosed a
single case somewhere in the world, he added.
The meeting in New York and one yesterday in San Francisco were
extraordinary because the disease was eradicated 20 years ago and
routine vaccinations stopped in the United States in 1971.
Many younger participants at the forum said they had never given
a smallpox vaccination, seen the disease or been vaccinated. Older
participants like Dr. Walter Orenstein, who directs the national
immunization program of the disease control centers, said, "I never
thought I'd be talking about smallpox except in an historical
context."
After the anthrax attacks last fall, the government expanded its
smallpox vaccine stockpile. Tests have shown that the 15 million
doses stored frozen since vaccinations stopped can be safely diluted
to 75 million while retaining potency. A drug company, Aventis
Pasteur, has donated 80 million doses that it has kept frozen since
1958. The government says that supply will be used only in an
emergency.
The government is also buying 220 million doses made by a new
technique. Delivery is expected by year's end. Because none of the
vaccine is licensed, its use would require signed consent from each
recipient.
The expanded supply has led officials to consider broader options
in vaccinating segments of the public. Deciding which segments and
how many participants is one of the thorniest public health
problems, largely because no one can predict if, when and where an
attack might occur and where the victims might seek care.
|