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NTP CHEMICAL REPOSITORY
              MERCURY((O-CARBOXYPHENYL)THIO)ETHYL, SODIUM SALT


-IDENTIFIERS
 ===========

*CATALOG ID NUMBER: 001097

*CAS NUMBER: 54-64-8

*BASE CHEMICAL NAME: MERCURYCARBOXYPHENYLTHIOETHYL,SODIUMSALT,O-

*PRIMARY NAME: MERCURY((O-CARBOXYPHENYL)THIO)ETHYL, SODIUM SALT

*CHEMICAL FORMULA: C9H9HgO2S.Na

*STRUCTURAL FORMULA: Not printable

*WLN: QVR BS-HG-2 &-NA-

*SYNONYMS:
  ((O-CARBOXYPHENYL)THIO)ETHYLMERCURY SODIUM SALT
  ELICIDE
  O-(ETHYLMERCURITHIO)BENZOIC ACID SODIUM SALT
  ETHYLMERCURITHIOSALICYLIC ACID SODIUM SALT
  ETHYLMERCURITHIOSALICYLATE SODIUM SALT
  MERCUROTHIOLATE
  MERZONIN SODIUM
  SET
  SODIUM ETHYLMERCURIC THIOSALICYLATE
  SODIUM MERTHIOLATE
  THIMEROSAL
  THIMEROSALATE
  THIMEROSOL
  THIMERSALATE
  THIOMEROSAL
  THIOMERSAL
  THIOMERSALATE
  MERCURATE(1-), ETHYL(2-MERCAPTOBENZOATO(2-)-O,S)-, SODIUM
  MERFAMIN
  MERTHIOLATE
  MERTHIOLATE SODIUM
  MERTORGAN
  SODIUM O-(ETHYLMERCURITHIO)BENZOATE
  MERCURY, ETHYL(HYDROGEN O-MERCAPTOBENZOATO)-, SODIUM SALT
  ETHYL(HYDROGEN O-MERCAPTOBENZOATO)MERCURY, SODIUM SALT
  MERZONIN
  NOSEMACK
  SODIUM 2-(ETHYLMERCURITHIO)BENZOATE
  MERSEPTYL
  THIOMERSALAT
  BENZOIC ACID, 2-MERCAPTO-, MERCURY COMPLEX
  ELCIDE 75
  ETHYL(2-MERCAPTOBENZOATO-S)MERCURY SODIUM SALT
  ETHYL (SODIUM O-MERCAPTOBENZOATO)MERCURY
  MERCURY, ETHYL(2-MERCAPTOBENZOATE-S), SODIUM SALT
  MERTHIOLATE SALT
  MERZONIN, SODIUM SALT
  SODIUM ETHYLMERCURITHIOSALICYLATE
  ETHYL(2-MERCAPTOBENZOATO(2-)-O,S)-MERCURATE(1-) SODIUM


-PHYSICAL CHEMICAL DATA
 ======================

*PHYSICAL DESCRIPTION: LITERATURE: Light cream-colored crystalline powder
                       REPOSITORY: White powder

*MOLECULAR WEIGHT: 404.82

*SPECIFIC GRAVITY: Not available

*DENSITY: Not available

*MP (DEG C): 232-233 C (decomposes) [269,275]

*BP (DEG C): Not available

*SOLUBILITIES:
       WATER : >=100 mg/mL @ 19 C (RAD)

        DMSO : >=100 mg/mL @ 19 C (RAD)

 95% ETHANOL : 10-50 mg/mL @ 19 C (RAD)

    METHANOL : Soluble [295]

     ACETONE : <1 mg/mL @ 19 C (RAD)

     TOLUENE : Not available

 OTHER SOLVENTS:
  Ether: Practically insoluble [033,062,233,295]
  Benzene: Practically insoluble [033,062]
  Alcohol: 1 g/8 mL [033,295]

*VOLATILITY:
    Vapor pressure: Not available
    Vapor density:  Not available

*FLAMMABILITY(FLASH POINT):
      Flash point data for this chemical are not available; however, it is
 probably combustible.  Fires involving this material can be controlled with
 a dry chemical, carbon dioxide or Halon extinguisher.  A water spray may
 also be used [269].

*UEL: Not available                         LEL: Not available

*REACTIVITY:
      This chemical is incompatible with acids, iodine, heavy metal salts
 and many alkaloids [295,455].  This chemical can be absorbed by rubber caps.
 It is incompatible with strong oxidizing agents and strong bases.  The rate
 of oxidation for this compound is greatly increased by traces of copper ions
 [295].

*STABILITY:
      This chemical is stable in air, but not sunlight [033,233].  It may
 discolor on exposure to light [269].  Dilute aqueous solutions of this
 chemical are fairly stable to heat but labile to light.  Solutions are less
 stable to heat when acidic than when alkaline.  Solutions are most stable to
 light at pH 5 to 7.  Solutions are unstable to heat but not to light in the
 presence of copper, iron or zinc ions but not in the presence of calcium or
 magnesium ions [295].  Solutions of this chemical in water, DMSO, 95% ethanol
 or acetone should be stable for 24 hours when protected from light (RAD).

*OTHER PHYSICAL DATA:
  pH of 1% aqueous solution: 6.7 [062]
  Slight odor [062,295]


-TOXICITY
 ========

*NIOSH REGISTRY NUMBER: OV8400000

*TOXICITY: (abbreviations)
        typ. dose    mode     specie      amount     units     other
          LD50       orl       rat           75      mg/kg
          LD50       scu       rat           98      mg/kg
          LD50       unr       rat           40      mg/kg
          LDLo       ivn       mus           30      mg/kg
          LD50       orl       mus           91      mg/kg
          LD50       ipr       mus           54      mg/kg
          LDLo       ial       chd           60      mg/kg/4W-I

*AQTX/TLM96: Not available

*SAX TOXICITY EVALUATION:
  THR: Poison by ingestion, subcutaneous, intravenous and possibly other
       routes.  An experimental neoplastigen and teratogen.  Experimental
       reproductive effects.

*CARCINOGENICITY:
  Tumorigenic Data:
    TDLo: scu-rat   104 mg/kg (1Y-I)

*MUTATION DATA: Not available

*TERATOGENICITY: See RTECS printout for data

*STANDARDS, REGULATIONS & RECOMMENDATIONS:
  OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z
        Transitional Limit: PEL-TWA 0.01 mg(Hg)/m3; Ceiling Limit 0.04 mg(Hg)/m3
                             [015,327,545,610]
        Final Limit: PEL-TWA 0.01 mg(Hg)/m3 (skin); STEL 0.03 mg(Hg)/m3 [015,
                      545,610]
  ACGIH: TLV-TWA 0.01 mg(Hg)/m3 (skin); STEL 0.03 mg(Hg)/m3 [610]
  NIOSH Criteria Document: None
  NFPA Hazard Rating: Health (H): None
                      Flammability (F): None
                      Reactivity (R): None

*OTHER TOXICITY DATA:
  Skin and Eye Irritation Data:
    eye-rbt  8 ug MLD
  Status: EPA Genetox Program 1988, Positive: S cerevisiae gene conversion
          EPA TSCA Chemical Inventory, 1986
  Human lethal dose: 2-4 grams [301]


-OTHER DATA (Regulatory)
 =======================

*PROPER SHIPPING NAME (IATA): Mercury compounds, solid, n.o.s.

*UN/ID NUMBER: UN2025

*HAZARD CLASS: 6.1           SUBSIDIARY RISK: None    PACKING GROUP: III

*LABELS REQUIRED: Keep away from food

*PACKAGING: PASSENGER: PKG. INSTR.: 619, Y619    MAXIMUM QUANTITY: 100 kg, 10 kg
            CARGO    : PKG. INSTR.: 619          MAXIMUM QUANTITY: 200 kg

*SPECIAL PROVISIONS: None

*USES:
      This compound is used as an ophthalmic preservative, a topical anti-
 infective and a topical veterinary antibacterial and antifungal agent.  It is
 also used as a bacteriostat and a fungistat.  It is an FDA over-the-counter
 drug.

*COMMENTS: Not available


-HANDLING PROCEDURES
 ===================

*ACUTE/CHRONIC HAZARDS:
      This compound is toxic by ingestion and inhalation [062].  It is an eye
 irritant.  When heated to decomposition it emits very toxic fumes of mercury,
 sodium oxide and sulfur oxides [043].

*MINIMUM PROTECTIVE CLOTHING: Not available

*RECOMMENDED GLOVE MATERIALS:
 GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
      This chemical has not been tested for permeation by Radian Corporation;
 however, the GlovES+ expert system was used to extrapolate permeation test
 information from compounds in the same chemical class.  The GlovES+ system uses
 permeation data from literature sources; therefore, extra safety margins should
 be used with the estimated protection time(s).  If this chemical makes direct
 contact with your glove, or if a tear, puncture or hole develops, replace them
 at once.
      The GlovES+ expert system is a tool that can help people better manage
 protection from chemicals, however this tool cannot replace sound judgment nor
 make technical decisions.  Our GlovES+ expert system is designed to offer
 initial advice and assistance in glove selection while the final glove
 selection should be made by knowledgeable individuals based on the specific
 circumstances involved.

 Glove Type            Model Number      Thickness   Estimated Protection Time
 Natural rubber        Edmont 36-124      0.51 mm            240 min
 Neoprene              Edmont 29-865      0.51 mm            240 min
 Nitrile               Edmont 36-175      0.46 mm            240 min
 PVC                   Edmont 34-100      0.20 mm            240 min

*RECOMMENDED RESPIRATOR:
      Where the neat test chemical is weighed and diluted, wear a NIOSH-
 approved half face respirator equipped with an organic vapor/acid gas
 cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
 dust/mist filter.

*OTHER: Not available

*STORAGE PRECAUTIONS:
      You should protect this compound from light and store it under
 ambient temperatures.

*SPILLS AND LEAKAGE:
      If you spill this chemical, you should dampen the solid spill material
 with water, then transfer the dampened material to a suitable container.  Use
 absorbent paper dampened with water to pick up any remaining material.  Seal
 your contaminated clothing and the absorbent paper in a vapor-tight plastic
 bag for eventual disposal.  Wash all contaminated surfaces with a soap
 and water solution.  Do not reenter the contaminated area until the Safety
 Officer (or other responsible person) has verified that the area has been
 properly cleaned.

*DISPOSAL AND WASTE TREATMENT: Not available


-EMERGENCY PROCEDURES
 ====================

*SKIN CONTACT:
      IMMEDIATELY flood affected skin with water while removing and isolating
 all contaminated clothing.  Gently wash all affected skin areas thoroughly
 with soap and water.
      If symptoms such as redness or irritation develop, IMMEDIATELY call a
 physician and be prepared to transport the victim to a hospital for treatment.

*INHALATION:
      IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
 IMMEDIATELY call a physician and be prepared to transport the victim to a
 hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
 or burning in the mouth, throat, or chest) develop.
      Provide proper respiratory protection to rescuers entering an unknown
 atmosphere.  Whenever possible, Self-Contained Breathing Apparatus (SCBA)
 should be used; if not available, use a level of protection greater than or
 equal to that advised under Respirator Recommendation.

*EYE CONTACT:
      First check the victim for contact lenses and remove if present.  Flush
 victim's eyes with water or normal saline solution for 20 to 30 minutes while
 simultaneously calling a hospital or poison control center.
      Do not put any ointments, oils, or medication in the victim's eyes without
 specific instructions from a physician.
      IMMEDIATELY transport the victim after flushing eyes to a hospital even if
 no symptoms (such as redness or irritation) develop.

*INGESTION:
      Some heavy metals are VERY TOXIC POISONS, especially if their salts are
 very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and
 arsenic).  IMMEDIATELY call a hospital or poison control center and locate
 activated charcoal, egg whites, or milk in case the medical advisor recommends
 administering one of them.  Also locate Ipecac syrup or a glass of salt water
 in case the medical advisor recommends inducing vomiting.  Usually, this is
 NOT RECOMMENDED outside of a physician's care.
      If advice from a physician is not readily available and the victim is
 conscious and not convulsing, give the victim a glass of activated charcoal
 slurry in water or, if this is not available, a glass of milk, or beaten egg
 whites and IMMEDIATELY transport victim to a hospital.
      If the victim is convulsing or unconscious, do not give anything by mouth,
 assure that the victim's airway is open and lay the victim on his/her side with
 the head lower than the body.  DO NOT INDUCE VOMITING.  IMMEDIATELY transport
 the victim to a hospital.

*SYMPTOMS:
      Symptoms of exposure to this class of compounds includes aphthous
 stomatitis, catarrhal gingivitis, nausea, liquid stools, pain, liver dis-
 order, injury to the cardiovascular system and hematopoietic system, deafness
 and ataxia.  Exposure may be fatal.  Headache, paresthesia of the tongue,
 lips, fingers and toes, other non-specific dysfunctions, metallic taste,
 slight gastrointestinal disturbances, excessive flatus and diarrhea may occur.
 Acute poisoning may cause gastrointestinal irritation and renal failure.  Early
 signs of severe poisoning include fine tremors of extended hands, loss of side
 vision, slight loss of coordination in the eyes, speech, writing and gait,
 inability to stand or carry out voluntary movements, occasional muscle atrophy
 and flexure contractures, generalized myoclonic movements, difficulty under-
 standing ordinary speech, irritability and bad temper progressing to mania,
 stupor, coma, mental retardation in children, skin irritation, blisters and
 dermatitis [173].  Other symptoms include chorea, athetosis, tremors, convul-
 sions, pain and numbness in the extremities, nephritis, salivation, loosening
 of the teeth, blue line on the gums, anxiety, mental depression, insomnia,
 hallucinations and central nervous system effects [301].  Exposure may also
 cause irritation of the eyes, mucous membranes and upper respiratory tract
 [269].


-SOURCES
 =======

*SOURCES:
 [015] Lewis, R.J., Sr. and R.L. Tatken, Eds.  Registry of Toxic Effects
          of Chemical Substances.  On-line Ed.  National Institute for
          Occupational Safety and Health.  Cincinnati, OH.  OV8400000.
          March 8, 1990.

 [029] Buckingham, J., Ed.  Dictionary of Organic Compounds.  5th Ed. and
          Supplements.  Chapman and Hall.  New York.  1988.  Vol. 5, p. 5341,
          #T-02044.

 [033] Budavari, Susan, Ed.  The Merck Index.  11th Ed.  Merck and Co., Inc.
          Rahway, NJ.  1989.  pp. 1467-1468, #9244.

 [043] Sax, N.I. and Richard J. Lewis, Sr.  Dangerous Properties of Industrial
          Materials.  7th Ed.  Van Nostrand Reinhold.  New York.  1989.
          Vol. III, p. 2205, #MDI000.

 [058] Information Handling Services.  Material Safety Data Sheets
          Service.  Microfiche Ed.  Bimonthly Updates.  February/March 1989.
          #1954-022, A-13.

 [062] Sax, N.I. and R.J. Lewis Sr., Eds.  Hawley's Condensed Chemical
          Dictionary.  11th Ed.  Van Nostrand Reinhold.  New York.  1987.
          p. 1147.

 [082] U.S. Environmental Protection Agency, Office of Toxic Substances.
          Toxic Substances Control Act Chemical Substance Inventory:  1985
          Edition.  5 Vols.  U.S. Environmental Protection Agency.
          Washington, D.C.  January 1986.  Listed.

 [099] Grant, W. Morton, M.D.  Toxicology of the Eye.  3rd Ed.  Charles
          C. Thomas, Publisher.  Springfield, IL.  1986.  p. 902.

 [110] Oak Ridge National Laboratory.  Environmental Mutagen Information
          Center (EMIC), Bibliographic Data Base.  Oak Ridge National
          Laboratory.  Oak Ridge, TN.  Listed.

 [120] Oak Ridge National Laboratory.  Environmental Teratogen Information
          Center (ETIC), Bibliographic Data Base.  Oak Ridge National
          Laboratory.  Oak Ridge, TN.  Listed.

 [151] Gosselin, R.E., H.C. Hodge, and R.P. Smith.  Clinical Toxicology
          of Commercial Products.  5th Ed.  Williams and Wilkins, Co.
          Baltimore.  1984.  p. II-138, #244.

 [165] Wiswesser, W.J., Ed.  Pesticide Index.  Entomological Society
          of America.  College Park, MD.  1976.  p. 146.

 [173] Hayes, W.J., Jr.  Pesticides Studied in Man.  Williams and
          Wilkins.  Baltimore.  1982.  pp. 20-23.

 [195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds.  CFTA Cosmetic
          Ingredient Dictionary.  3rd Ed.  The Cosmetic, Toiletry and
          Fragrance Assn. Inc.  Washington.  1982.  p. 317.

 [205] Dean, John A., Ed.  Lange's Handbook of Chemistry.  13th Ed.
          McGraw-Hill Book Company.  New York.  1985.  p. 7-401, #e286.

 [233] Wardell, J.L., Ed.  Organometallic Compounds of Zinc, Cadmium and
          Mercury.  Chapman and Hall.  London.  1985.  p. 89, #Hg-00546.

 [269] Lenga, Robert E.  The Sigma-Aldrich Library of Chemical Safety Data.
          Edition 1.  Sigma-Aldrich Corporation.  Milwaukee, WI.  1985.
          p. 919, #D.

 [275] Aldrich Chemical Company.  Aldrich Catalog/Handbook of Fine
          Chemical.  Aldrich Chemical Co., Inc.  Milwaukee, WI.
          1988.  p. 721, #E3,525-7.

 [295] Reynolds, James E.F., Ed.  Martindale The Extra Pharmacopoeia.  28th Ed.
          The Pharmaceutical Press.  London.  1982.  p. 576, #2281-s.

 [301] Dreisbach, R.H.  Handbook of Poisoning: Prevention, Diagnosis
          and Treatment.  11th Ed.  Lange Medical Publications.  Los
          Altos, CA.  1983.  p. 263.

 [327] Office of the Federal Register National Archives and Records
          Administration.  Code of Federal Regulations, Title 29, Labor,
          Parts 1900 to 1910.  U.S. Government Printing Office.
          Washington.  1988.  p. 710.

 [346] Sittig, M.  Handbook of Toxic and Hazardous Chemicals and Carcinogens.
          2nd Ed.  Noyes, Publications.  Park Ridge, NJ.  1985.  pp. 567-568.

 [415] American Conference of Governmental Industrial Hygienists.
          Threshold Limit Values and Biological Exposure Indices
          for 1988-1989.  American Conference of Governmental
          Industrial Hygienists.  Cincinnati, OH.  1988.  p. 25.

 [421] American Conference of Governmental Industrial Hygienists.
          Documentation of the Threshold Limit Values.  5th Ed.
          American Conference of Governmental Industrial Hygienists.
          Cincinnati, OH.  1986.  p. 360.

 [455] The Pharmaceutical Society of Great Britain.  The Pharmaceutical Codex.
          11th Edition.  The Pharmaceutical Press.  London.  1979.
          pp. 940-941.

 [545] Office of the Federal Register National Archives and Records
          Administration.  Federal Register, Dept. of Labor, Part III.
          U.S. Government Printing Office.  Washington.  January 19, 1989.
          p. 2942.

 [610] Clansky, Kenneth B., Ed.  Suspect Chemicals Sourcebook:  A Guide to
          Industrial Chemicals Covered Under Major Federal Regulatory and
          Advisory Programs.  Roytech Publications, Inc.  Burlingame, CA.
          1990.  Section 3, p. 7, 110.

 [620] United States National Toxicology Program.  Chemical Status Report.
          NTP Chemtrack System.  Research Triangle Park, NC.  November 6, 1990.
          Not listed.

         -------------------------------------------------------------

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