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June 21, 2002
U.S. IMMUNIZATION NEWS
"Identification of in Vivo Expressed Vaccine Candidate Antigens From Staphylococcus aureus" Proceedings of the National Academy of Sciences Online
(www.pnas.org) (05/14/02) Vol. 99, No. 10, P. 6573; Etz, Hildegard; Minh, Duc Bui; Henics, Tamas
The article asserts that vaccines can only be effective if the diseases they prevent are recognized within the community in which they are used. A group of researchers has created a fast and effective way to identify antigens, beginning with the comprehensive antigenic profile of Staphylococcus aureus. Peptides of S. aureus were found to display a total of 60 antigenic proteins, the majority of which are found on the surface of the bacterium or secreted. The process was made possible through genomic research. Now that they have been identified, the proteins will help to create effective vaccine candidates for further research and will increase the effectiveness of future pathogens that contain antibodies in humans.
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