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Collections under which this article appears: Clinical Research Allergy Dermatology Children

BMJ 2002;324:1376-1379 ( 8 June )

Clinical review

Childhood atopic eczema

Ross St C Barnetson, professor of dermatology ^a, Maureen Rogers, paediatric dermatologist ^b. 

^a Department of Dermatology, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia, ^b Department of Dermatology, New Children's Hospital, Westmead, Sydney, Australia

Correspondence: R St C Barnetson ross@canc.rpa.cs.nsw.gov.au

	Introduction

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Atopic eczema is a common condition that affects more than one in ten children in developed countries, and the incidence is increasing. There are probably several reasons for this, including higher exposure to air pollution, smaller families with less exposure to infections, more pets, higher maternal age, and a wider range of foods. There is clearly also an important hereditary component to atopic eczema. This is complex because not all affected children are atopic, though the genes implicated in atopy are likely to be involved, together with others as yet unknown. Atopic eczema usually presents during the first year of life, and when it is severe it is extremely disabling. It may also cause major psychological problems. Most affected children are also allergic to house dust mite, and this is probably a major cause of exacerbation of the condition. Probably less than 10% overall have IgE mediated food allergy, but some have late phase reactions with positive results on patch tests to foods.
 

	Methods

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We searched Medline for entries on atopic eczema and atopic dermatitis in children and adults. We also relied on our personal experience in treating children with atopic eczema over the past 30 years.

	Clinical features

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Atopic eczema is usually the first manifestation of atopy and may coincide with food allergy; asthma often follows, then allergic rhinitis (fig 1).

View larger version (18K): [in this window] [in a new window]   Fig 1.   Incidence of different types of atopy by age (adapted with permission from W B Saunders1)

There is a wide spectrum of presentations of atopic eczema, from minimal flexural eczema (fig 2) to erythroderma. The skin of a child with eczema is generally dry. The eczema can occur anywhere, but there are particular patterns that are more common at certain ages. The face is usually the first to be affected (fig 3). In crawling infants the forearms, extensor aspects of the knees, and the ankle flexures are often the most affected. In older children the flexor aspects of the elbows and the knees are mostly affected. The eczema may be moist and weeping or may be thickened (lichenified) and dry. In children with darker skin the rash may have a papular nature. Scratch marks are always seen. The course of the condition fluctuates: causes of exacerbations may be evident but usually are not.

Infective complications are common. Staphylococcal infection may manifest as typical bullous impetigo or simply as a worsening of the eczema with increased redness and oozing. Staphylococcal folliculitis may occur as a result of occlusion from greasy emollients or wet dressings. Streptococcal infection may manifest as increased redness and erosion of the skin or as pustular lesions. Atopic children are particularly prone to severe widespread herpes simplex infections; the spread of the condition is mainly systemic but the areas most affected are the areas of active eczema.

	Psychological issues

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The child's life is limited by the constraints of care of the skin, which can separate the child from his or her peers.² This can include sport, swimming, and dietary restrictions. The child feels unattractive and different and may have problems with self image and self confidence.

(Credit: DR P MARAZZI/SPL) View larger version (88K): [in this window] [in a new window]   Fig 2.   Flexural eczema in bend of child's leg

	Precipitating factors

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There are several possible precipitating factors.
 

Inhalant allergens
Most children with eczema are atopic and are therefore allergic to inhalants such as house dust mite (Dermatophagoides pteronyssinus), grass pollens, and animal dander. Some children develop eczema on the face during the pollen season, and many parents report that their child's eczema is worse after close contact with pets. The highest proportion of IgE is produced against house dust mite, and this must be the most important allergen in the exacerbation of eczema.³

House dust mite is present in large numbers in children's beds and as well as causing asthma causes exacerbations of eczema. Several studies have shown that actions to reduce dust mite numbers are associated with amelioration of eczema.⁴ This is not surprising as in children highly allergic to the mites, skin contact is bound to have a deleterious effect on the eczema. The role of delayed hypersensitivity to house dust mite is also likely to be important. People with atopic eczema have positive results to patch tests⁵ and positive lymphoproliferative responses to the mite. Unfortunately, in everyday life minimisation of house dust mite in bedding is difficult to achieve.

Food allergy and intolerance
In general, food allergy is caused by immunological mechanisms, food intolerance is not. Food intolerance is relatively common: certain chemicals in foods may cause worsening of the eczemafor example, tartrazine or other colourings in foodby mechanisms that are unclear.

Food allergy is age dependent. It may be severe in the infant and become less so with age. Allergy to some foods (such as egg and cows' milk) is relatively transient, whereas allergy to peanuts or shellfish may continue throughout life.

(Credit: DR P MARAZZI/SPL) View larger version (90K): [in this window] [in a new window]   Fig 3.   Eczema on face and head

The association between atopic eczema and food allergy is complex, though it is usually children with severe atopic eczema who have food allergy. Probably less than 10% of all children with atopic eczema have IgE mediated food allergy with angioedema and urticaria, when the diagnosis is obvious from the immediacy of the symptoms and can be confirmed by a wheal >5 mm in diameter after a skin prick test. Some of these children have multiple food allergies. There is no doubt that IgE mediated food allergy can act as a trigger for exacerbations of eczema,⁶ but most parents recognise the allergy and the food is avoided. What is not clear is the role of late phase food reactions, which cause exacerbations of the eczema without urticaria or angioedema. These can be confirmed by atopy patch tests⁷ and food provocation tests. This is receiving increasing attention.
 

Irritants
Woollen material in direct contact with the skin is a major irritant. Shiny nylon materials and some acrylics may irritate, but cotton-polyester mixtures are usually well tolerated. Soap in excess and bubble baths excessively dry the skin, and many perfumed and "medicated" products applied to the skin will cause irritation. Some of the plant extract preparations favoured by alternative practitioners act as irritants or allergens and a query about the use of these should always be part of the history taking.

	Management

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Explanation and counselling are a vital part of the successful management of childhood eczema. Parents will have received a barrage of advice from a range of medical, paramedical, and non-medical "experts" and require a clear understanding of the nature of the condition, a long term management plan, and a realistic expectation of the results of treatment.

Terminology is often confusing; the terms atopic eczema and atopic dermatitis are often used synonymously. It is essential to talk in terms of control rather than cure, otherwise parents will search for an end point after which care will no longer be required, and this is an unrealistic expectation. The condition should be explained as a multifactorial disorder, and it must be appreciated that just as there is no "cure" there is no single "cause." Often no explanation can be found for a particular flare up of the condition, and many factors are probably working in combination at all times.

Dealing with dryness
Bath oils and products containing oatmeal are useful and prevent the drying of the skin that bathing can induce. Bath oils that contain antiseptic may have added benefit in certain cases but have a tendency to overdry and sometimes actually irritate the skin. The child should have either a bath with additive or a short shower. It is essential to find a suitable moisturiser that can be applied all over twice a day whether or not there is active eczema. Creams containing cetomacrogol, emulsifying ointment, and creams or ointments with lanolin can be used. If a product stings the skin it must be abandoned. The most likely irritant in emollient creams is the stabiliser propylene glycol. Products that contain urea almost always sting broken skin and are unsuitable in these children.

Use of wet dressings
Wet dressings are useful in children with severe widespread eczema.⁸ This is essentially an inpatient procedure but can be used for short periods at home. A water based emollient is applied all over; a corticosteroid cream (rather than ointment in this case because cream is more water miscible) is applied to the areas of active eczema. The creams are covered with a double layer of wrapping, the innermost of which is wetted with tepid water. The material may be cotton sheeting covered with a crepe bandage, though an easier alternative is the use of a double layer of tubular elasticated bandage. The procedure is repeated three times a day. This treatment is usually effective in clearing the eczema in three or four days.

Avoidance of allergens
House dust mite is the most important allergen. Avoidance measures have to be carried out assiduously and must include encasing the mattress and pillows as well as dealing with the top covers, either by encasement or by hot (>60°C) washing.

If food allergy is suspected, the child should be referred to a paediatric dietician. In general, it is children with severe atopic eczema who have food allergy or food intolerance. Children with flexural eczema are unlikely to have food allergy, unless the history suggests otherwise.

Topical corticosteroids
It is often necessary to spend some time counselling the parents that topical steroid preparations used appropriately are safe. The strength chosen depends on the severity of the eczema and the site affected. The frequency of application depends on the individual product.

Topical antibacterials
Staphylococcus aureus is commonly cultured from eczematous skin, and there may be obvious signs of infection. For localised infections, fusidic acid ointment may be effective. To prevent infections it is useful to bathe the child in preparations containing triclosan⁹ or benzalkonium chloride.

Topical immunosuppressants
Tacrolimus is a potent immunosuppressive drug used in organ transplantation. A topical formulation has been shown to be effective in trials in patients with moderate to severe atopic dermatitis. Two studies specifically related to childhood eczema have confirmed its efficacy. ^{10 11} The main side effect is a sensation of burning. A concern has been raised as to whether application to skin exposed to sun could increase the long term risk of skin cancer.

Pimecrolimus (an ascomycin derivative) is a newer immunosuppressive agent, similar to tacrolimus. Preliminary studies in children look encouraging.¹²

Oral medications
 

Immunosuppressive drugs
Severe atopic eczema is a serious condition, with huge loss of quality of life for the child on a par with juvenile rheumatoid arthritis. It is therefore essential that such children are treated adequately.

The use of oral steroids should be avoided because of severe rebound of the eczema on withdrawal, the eczema becoming unstable after several courses, and the long term side effects. There are generally two alternatives for severe eczema, cyclosporin and azathioprine.

CiclosporinRecent studies have confirmed the efficacy of ciclosporin in childhood atopic eczema. ^{13 14} Regrettably the improvement is often not maintained after withdrawal of the drug. Continuous treatment is rarely justified in view of the long term risks (such as hypertension and renal dysfunction). However, it has a place as an effective, safe, and well tolerated short term option for the management of severe refractory disease in children.
 

Azathioprine is a safer drug for long term use, though it does have several side effects, including nausea, fatigue, myalgia, and liver dysfunction. It is used by paediatric dermatologists in the United Kingdom.¹⁵ It is essential to assay for thiopurine methyl transferase before treatment starts as children deficient in this enzyme will experience marked bone marrow suppression. In most children it is effective at low dosage. The main long term side effect that could theoretically occur (as with ciclosporin) is the development of lymphoma. The advantage of this drug is that it can be used continuously.

Other possibilities include the leukotriene inhibitors zafirlukast¹⁶ and montelukast,¹⁷ given orally. Chinese herbal medicines have also been used successfully but are not without danger.¹⁸

Antihistamines
Sedating antihistamines such as alimemazine and promethazine given at bedtime are both useful. The sedation is an important feature of their antipruritic action. It is still debatable whether non-sedating antihistamines such as cetirizine and loratadine are useful because generally the role of histamine in eczema is somewhat limited. However, a large study of the use of cetirizine in adults with atopic eczema showed a significant reduction of clinical manifestations in those treated.¹⁹

	Footnotes

   Competing interests: None declared.

	References

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© BMJ 2002
 

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Collections under which this article appears: Clinical Research Allergy Dermatology Children

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