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[Evaluation of the toxic action of
prophylactic and therapeutic preparations on cell cultures. III. The
detection of toxic properties in medical biological preparations by the
degree of cell damage in the L132 continuous cell
line].
[Article in Russian]
Kravchenko AT, Dzagurov SG, Chervonskaia GP.
The methods of the quality control of medical biological preparations,
including tests on animals, do not ensure the complete absence of toxicity in
a final
product. The use of the method of "subcultures with the introduced
preparation" makes it possible to determine the toxicity of both
specific and nonspecific components of vaccines and sera from the number of
dead and damaged cells. The toxic action of preparations kills and damages
the cells at the site of injection, thus inducing the formation of autoantigens
whose effect on the body cannot be predicted. Thus thimerosal, commonly used
as preservative, has been found not only to render its primary toxic effect,
but also capable of changing the properties of cells. This fact suggests that
the use of thimerosal for the preservation of medical biological
preparations, especially those intended for children,
is inadmissible.
MeSH Terms:
·
Allergens/toxicity
·
Animal
·
Bacterial Vaccines/toxicity
·
Biological Products/toxicity*
·
Cell
Line
·
Cells, Cultured
·
Immunoglobulins/toxicity
·
L Cells (Cell
Line)/drug effects*
·
Methods
·
Mice
·
Quality Control
·
Thimerosal/toxicity
·
Viral Vaccines/toxicity
Substances:
·
Thimerosal
·
Viral Vaccines
·
Immunoglobulins
·
Biological Products
·
Bacterial Vaccines
·
Allergens
PMID: 6845931 [PubMed - indexed for MEDLINE]
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