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"Use of an Inactivated Varicella Vaccine in Recipients of Hematopoietic-Cell Transplants"Immunization Newsbriefs (c) Copyright Information Inc., Bethesda, MD. Brought to you by the National Network for Immunization Information (NNii). Visit NNii's new website at http://www.immunizationinfo.org.
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July 15, 2002
U.S. IMMUNIZATION NEWS
"Use of an Inactivated Varicella Vaccine in Recipients of Hematopoietic-Cell Transplants" New England Journal of Medicine Online (www.nejm.org) (07/04/02) Vol. 347, No. 1, P. 26; Hata, Atsuko; Asanuma, Hideomi; Rinki, Mary
Patients who receive hematopoietic-cell transplants often contract zoster from the reactivation of varicella-zoster virus from latency. To determine if a varicella vaccine would be effective in preventing the illness, 119 patients who were to receive hematopoietic-cell transplants were enrolled in a trial of a varicella vaccine, and were given either the vaccine or placebo at 30 days before transplantation and 30 days, 60 days, and 90 days after the process. The goal of the program was to prevent varicella-zoster virus for a period of 12 months. In the vaccinated group of 53 patients, zoster developed in seven, compared to 19 patients in the unvaccinated group of 58 patients. The respective rates of infection were 13 percent and 30 percent. Patients who received the vaccine had higher in vitro CD4 T-cell proliferation against varicella-zoster at all points in the study than those without the vaccination. The findings indicate that vaccinating patients against varicella-zoster before hematopoietic-cell transplantation can lower the risk of contracting the illness for at least 12 months. ALL INFORMATION, DATA, AND
MATERIAL CONTAINED, PRESENTED, OR PROVIDED HERE IS FOR GENERAL INFORMATION
PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS REFLECTING THE KNOWLEDGE OR OPINIONS
OF THE PUBLISHER, AND IS NOT TO BE CONSTRUED OR INTENDED AS PROVIDING MEDICAL OR
LEGAL ADVICE. THE DECISION WHETHER OR NOT TO VACCINATE IS AN IMPORTANT AND
COMPLEX ISSUE AND SHOULD BE MADE BY YOU, AND YOU ALONE, IN CONSULTATION WITH
YOUR HEALTH CARE PROVIDER.
DISCLAIMER: All information, data, and material contained, presented, or provided here is for general information purposes only and is not to be construed as reflecting the knowledge or opinions of the publisher, and is not to be construed or intended as providing medical or legal advice. The decision whether or not to vaccinate is an important and complex issue and should be made by you, and you alone, in consultation with your health care provider.
Copyright 2012 by Vaccination News, A Non-Profit Corporation. All Rights Reserved. This content may not be copied unless permission in writing from Sandy Gottstein has been obtained. 
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 "A foolish faith in authority is the worst enemy of truth." -- Albert Einstein, letter to a friend, 1901 "I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education." -- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820 "What's the point of vaccination if it doesn't protect you from the unvaccinated?" -- Sandy Gottstein "Who gets to decide what the greater good is and how many will be sacrificed to it?" -- Sandy Gottstein |