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_______________________________________________________________________
MedPulse is a weekly index of key news and features on Medscape's
specialty sites compiled by Medscape's Editors.
_______________________________________________________________________
___________________ NEW FEATURE ARTICLES THIS WEEK ____________________
-- XIV INTERNATIONAL AIDS CONFERENCE --
Reports from the Barcelona meeting are both promising and disappointing. Read
Medscape's coverage of the highs and lows in today's treatment strategies.
Daily coverage by our on-site clinical experts includes:
- Which First-line Regimen?
- Short-Course HAART During Primary HIV Infection
- Compelling Evidence of HIV-1 Superinfection
- Stopping Therapy Is Safe in "Prematurely Treated" Patients
- Deferred Therapy May Result in Impaired Immune Function
- PI Therapy Associated With Increased Rate of Heart Disease
- Low CD4+ Count Predicts Virologic Failure in Patients Starting HAART
- Risk Factors for Disease Progression Among Naive Patients Starting HAART
98TH INTERNATIONAL CONFERENCE OF THE AMERICAN THORACIC SOCIETY
Coverage includes management of ARDS, asthma, ventilators, and sleep disorders,
as well as clinical controversies.
Medscape Pulmonary Medicine 6(2) 2002
medscape.com/viewprogram/1930?srcmp=id-071202
HIGHLIGHTS FROM THE 98TH INTERNATIONAL CONFERENCE OF THE AMERICAN THORACIC
SOCIETY, MAY 17-22, 2002, ATLANTA, GEORGIA
Information on care of lung transplant candidates and new innovations that may
defer the need for transplantation.
Medscape Transplantation 3(2) 2002
medscape.com/viewarticle/436464?srcmp=id-071202
HAART AND PREVENTION OF HIV TRANSMISSION
A wide-ranging report on the potential role of antiretroviral therapy in HIV
prevention, based on 11 expert reviews
Medscape HIV/AIDS 8(2) 2002
medscape.com/viewarticle/437545?srcmp=id-071202
OUTBREAKS OF ORAL WARTS COINCIDING WITH HAART?
How should we manage an HIV+ patient who has severe outbreaks of oral warts
during HAART which disappear off-therapy?
Medscape HIV/AIDS 8(2) 2002
medscape.com/viewarticle/437557?srcmp=id-071202
-- MEDSCAPE JOURNAL SCAN --
PULMONARY MEDICINE, APRIL 2002
A review of the current literature in the pulmonary field, including:
- Clinical Findings and Lung Pathology in Children With Cystic Fibrosis
Medscape Pulmonary Medicine 6(1) 2002
- Nontypeable Haemophilus influenzae in Carriage and Disease: A Difference in
IgA1 Protease Activity Levels
medscape.com/viewarticle/437580?srcmp=id-071202
CRITICAL CARE, MAY 2002
A review of the current literature in the critical care field, including:
- Alcohol-Based Handrub Improves Compliance With Hand Hygiene in Intensive Care
Units
- Incidence and Outcome of Polymicrobial Ventilator-Associated Pneumonia
Medscape Critical Care 3(1) 2002
- Relevance of Mutations in the TLR4 Receptor in Patients With Gram-Negative
Septic Shock
medscape.com/viewarticle/438083?srcmp=id-071202
-- MEDSCAPE GENERAL MEDICINE --
HIGH PREVALENCE OF FASCIOLOPSIS BUSKI IN AN ENDEMIC AREA OF LIVER FLUKE
INFECTION IN THAILAND
Preventable parasitic infections are still prevalent in many remote areas of
Thailand.
Medscape General Medicine 4(3) 2002
medscape.com/viewarticle/437120?srcmp=id-071202
HIGH PREVALENCE OF HBsAg SEROPOSITIVITY IN HILLTRIBERS IN THE MAE JAM DISTRICT
IN NORTHERN THAILAND
Of the estimated 50 million new cases of hepatitis B virus infection diagnosed
annually worldwide, 75% occur in Asia.
Medscape General Medicine 4(3) 2002
medscape.com/viewarticle/437398?srcmp=id-071202
PALPITATIONS IN A FORMER BUTCHER
This 41-year-old former lamb butcher from Iraq also had a 2-year history of
abdominal fullness and pain.
Infect Med 19(5) 2002
medscape.com/viewarticle/436721?srcmp=id-071202
PEDIATRIC BULLETIN - WINNING THE BATTLE AGAINST PERINATAL INFECTIONS
Preventive strategies coupled with adherence and postimplementation surveillance
have been key.
Infect Med 19(5) 2002
medscape.com/viewarticle/436723?srcmp=id-071202
SCREENING ORGAN DONORS FOR CHAGAS DISEASE? EUROPEAN HOSPITALS: MANDATORY
SURVEILLANCE FOR S AUREUS; BENEFIT OF PICOVIR OUTWEIGHED BY SIDE EFFECTS;
CARELESS HANDLING BEHIND RECENT CUTANEOUS ANTHRAX CASE; LYME DISEASE RASH: NOT
ALWAYS BULL'S-EYE
Review recent news in infectious diseases.
Infect Med 19(5) 2002
medscape.com/viewarticle/436722?srcmp=id-071202
-- OTHER JOURNALS --
INTRAVENOUS IMMUNOGLOBULINS: CLINICAL EXPERIENCE AND VIRAL SAFETY
Rigorous donor screening and plasma testing must continue to be implemented in
order to ensure safety.
J Am Pharm Assoc 42(3) 2002
medscape.com/viewarticle/436640?srcmp=id-071202
ROLE OF CORPECTOMY FOR MANAGING CERVICAL SPONDYLOSIS
Surgical advances have expanded the role of corpectomy for managing
cervical spondylosis. Review indications, techniques, complications,
and outcomes in "Role of Corpectomy in Cervical Spondylosis," available
in the Spine Surgery area of the Medscape Spine Disorders Resource Center
at
medscape.com/mp/rc/spine
----------------
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For information on advertising in our e-mail newsletters -- like this MedPulse
you are reading -- or other creative advertising opportunities with WebMD
Medscape, please send an email to:
nycps-salessupport@exchange.webmd.net
SMALLPOX VACCINE STUDY LAUNCHED
Kaiser Permanente announced today that it has begun vaccinating volunteers in a
new study comparing the effectiveness of two versions of a smallpox vaccine.
Reuters Health Information 2002
medscape.com/viewarticle/438130?srcmp=id-071202
MASS VACCINATION WOULD STOP SMALLPOX OUTBREAK SOONER THAN CURRENT CDC PLAN
Mass vaccination in the event of a smallpox attack would stop an epidemic faster
and result in fewer deaths than would the strategy recommended by the CDC,
according to a report in the Proceedings of the National Academy of Sciences
Early Edition for July 8.
Reuters Health Information 2002
medscape.com/viewarticle/438100?srcmp=id-071202
AUTOCLAVE LETS MORE LABS SAFELY TEST FOR BIOTERROR AGENTS
Physicians are 'frontline soldiers' in bioterror war; recognition of symptoms is
crucial.
Medscape Medical News 2002
medscape.com/viewarticle/438160?srcmp=id-071202
-- PLAGUE --
BUBONIC PLAGUE DETECTED IN KAZAKHSTAN
A case of bubonic plague has been reported in southwestern Kazakhstan, and
physicians have placed those in contact with the infected person in isolation,
the state television channel Khabar said on Monday.
Reuters Health Information 2002
medscape.com/viewarticle/438101?srcmp=id-071202
-- DENGUE --
NINTH DEATH FROM DENGUE HEMORRHAGIC FEVER IN HONDURAS
A seven-year-old girl died from dengue hemorrhagic fever on Tuesday in a
hospital in northern, according to health authorities in Tegucigalpa, the
capital.
Medscape Medical News 2002
medscape.com/viewarticle/438243?srcmp=id-071202
-- MALARIA --
WHO SEEKS US APPROVAL FOR ANTI-MALARIA DRUG
The World Health Organization on Wednesday will present its case for US approval
of a malaria drug that may save the lives of patients around the world who now
lack access to emergency treatment.
Reuters Health Information 2002
medscape.com/viewarticle/438259?srcmp=id-071202
-- LEISHMANIASIS --
PAMIDRONATE SHOWS PROMISE IN CUTANEOUS LEISHMANIASIS
The bisphosphonate pamidronate appears to effect a radical cure in an
experimental model of cutaneous leishmaniasis, researchers at the University of
Illinois at Urbana-Champaign report in the July 1st issue of The Journal of
Infectious Diseases.
Reuters Health Information 2002
medscape.com/viewarticle/438105?srcmp=id-071202
-- HEPATITIS --
HCV TREATMENT MAY IMPROVE OUTCOME IN SPLENIC LYMPHOMA
In this small study, interferon was helpful only in patients with HCV infection.
Medscape Medical News 2002
medscape.com/viewarticle/438240?srcmp=id-071202
HEPATITIS B VACCINE SAFE AND EFFECTIVE IN RHEUMATOID ARTHRITIS PATIENTS
Hepatitis B vaccine can be safely used to protect patients with rheumatoid
arthritis against infection with the virus, according to a report in the July
issue of the Annals of the Rheumatic Diseases.
Reuters Health Information 2002
medscape.com/viewarticle/438332?srcmp=id-071202
GI DECONTAMINATION FAILS TO PREVENT INFECTION IN LIVER TRANSPLANT RECIPIENTS
Selective decontamination of the gastrointestinal tract in liver transplant
recipients does not prevent postoperative infections, but it does alter the
types of infections that occur, according to a recent report.
Reuters Health Information 2002
medscape.com/viewarticle/438283?srcmp=id-071202
-- VACCINES & IMMUNIZATION --
VACCINES AGAINST TYPES IV AND VII GROUP B STREPTOCOCCUS EFFECTIVE IN ANIMALS
Conjugate vaccines against the uncommonly encountered types IV and VII of group
B Streptococcus (GBS) are effective in mice and rabbits and could be
incorporated into the human vaccine for GBS, according to a report in the July
1st issue of The Journal of Infectious Diseases.
Reuters Health Information 2002
medscape.com/viewarticle/438262?srcmp=id-071202
REMUNE, OTHER VACCINES PRIME IMMUNE SYSTEM WITHOUT IL-2
A 38-patient study sponsored by the Adult AIDS Clinical Trials Group of the
National Institutes of Health shows the patients developed stronger immune
responses to HIV after receiving only Remune, an investigational therapeutic
vaccine, than they did when they received Remune plus interleukin 2 (IL-2).
Reuters Health Information 2002
medscape.com/viewarticle/438293?srcmp=id-071202
NEW AIDS VACCINE CONSORTIUM ZEROES IN ON NEUTRALIZING ANTIBODIES
The International AIDS Vaccine Initiative, together with the Vaccine Research
Center at the National Institute of Allergy and Infectious Diseases at the US
National Institutes of Health, has launched a 5-year initiative to investigate
HIV neutralizing antibodies, which they hope will accelerate the development of
an AIDS vaccine.
Reuters Health Information 2002
medscape.com/viewarticle/438186?srcmp=id-071202
THERAPEUTIC DNA VACCINE TO BE TESTED IN PATIENTS WITH CHRONIC HIV INFECTION
Researchers in Italy and the US will soon begin human trials with a
'therapeutic' AIDS vaccine designed to help people infected with HIV control the
infection in combination with drugs.
Reuters Health Information 2002
medscape.com/viewarticle/438279?srcmp=id-071202
AIDS VACCINE STILL SEEN TO BE A LONG WAY OFF
A vaccine that offers at least partial protection against HIV could be available
within a decade, but poor countries will be left without access for years longer
unless manufacturing and distribution capacity is built now, a leading
researcher said on Saturday.
Reuters Health Information 2002
medscape.com/viewarticle/438098?srcmp=id-071202
-- CJD/BSE --
FRENCH COURT RULES WOMAN'S GROWTH-HORMONE TREATMENT LED TO CJD DEATH
A French court ordered two medical associations on Tuesday to pay damages to the
family of a woman who died from Creutzfeldt-Jakob Disease (CJD) after receiving
growth hormone therapy.
Reuters Health Information 2002
medscape.com/viewarticle/438271?srcmp=id-071202
STATISTICAL TREND PREDICTS 32 MORE VCJD DEATHS IN UK THIS YEAR
Thirty-two more Britons will die from the human form of 'mad cow' disease if
current trends continue, government backed scientists said on Tuesday.
Reuters Health Information 2002
medscape.com/viewarticle/438184?srcmp=id-071202
-- INFLUENZA --
FDA REQUESTS MORE DATA FOR MEDIMMUNE'S FLUMIST
MedImmune Inc. said on Thursday that the US Food and Drug Administration (FDA)
has requested additional information regarding its biologics license application
(BLA) for the intranasal influenza vaccination FluMist.
Reuters Health Information 2002
medscape.com/viewarticle/438347?srcmp=id-071202
-- ANTIBIOTIC RESISTANCE --
CARBAPENEM-RESISTANT BACTERIA WIDESPREAD THROUGHOUT HOSPITALS IN BROOKLYN
Strains of multidrug-resistant Acinetobacter baumannii and Pseudomonas
aeruginosa have become endemic to hospitals in the Brooklyn, New York area,
investigators report in the Archives of Internal Medicine for July 8.
Reuters Health Information 2002
medscape.com/viewarticle/438112?srcmp=id-071202
-- H PYLORI --
VIRULENT FORM OF H. PYLORI LINKED TO ATHEROSCLEROTIC STROKE
Infection with more virulent strains of Helicobacter pylori is more common among
patients with atherosclerotic stroke than among patients with other types of
strokes or healthy subjects, according to a report published in the July 9th
rapid access issue of Circulation, to be published in the July 30th print issue.
Reuters Health Information 2002
medscape.com/viewarticle/438107?srcmp=id-071202
-- OTHER ID NEWS --
FIRST ENGINEERED VIRAL cDNA ABLE TO PRODUCE INFECTIOUS VIRUS
For the first time, an infectious virus has been synthesized in vitro based
solely on its known genome and without a natural template or use of any living
organisms, researchers from the State University of New York at Stony Brook
report.
Reuters Health Information 2002
medscape.com/viewarticle/438321?srcmp=id-071202
SURGEON GENERAL NOMINEE FACES TOUGH QUESTIONS AT CONFIRMATION HEARING
Months after his nomination was announced to become the next Surgeon General of
the United States, Arizona trauma surgeon and deputy sheriff Dr. Richard Carmona
finally got his hearing before the US Senate Health, Education, Labor and
Pensions Committee Tuesday, where he faced pointed questions about allegations
made Monday in an article in the Los Angeles Times.
Reuters Health Information 2002
medscape.com/viewarticle/438163?srcmp=id-071202
EARLY VIRAL INFECTION MAY TRIGGER ASTHMA
A single paramyxoviral infection in mice results in airway hyperreactivity and
goblet cell hyperplasia that persists for a year after the virus has been
cleared, according to the report in the July 15th issue of The Journal of
Clinical Investigation.
Reuters Health Information 2002
medscape.com/viewarticle/438325?srcmp=id-071202
SIMIAN 40 VIRUS SEEN AS ENTRENCHED IN HUMANS, BUT ONCOGENICITY DISPUTED
Though there is still no clear consensus, a majority of researchers told a
quasi-governmental health panel Thursday that simian virus 40 (SV40) has become
established in humans, and that it plays a role in causing cancer-- including in
people who had virus-contaminated polio vaccines in the 1950s and 1960s.
Reuters Health Information 2002
medscape.com/viewarticle/438346?srcmp=id-071202
NEW MEETING COVERAGE: VISIT THE CONFERENCE CENTER
Catch up on hot topics from some of the year's most important
medical meetings, with Medscape Conference Coverage. Free
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LEGAL ADVICE. THE DECISION WHETHER OR NOT TO VACCINATE IS AN IMPORTANT AND
COMPLEX ISSUE AND SHOULD BE MADE BY YOU, AND YOU ALONE, IN CONSULTATION WITH
YOUR HEALTH CARE PROVIDER.
"A foolish faith in authority is the worst enemy of truth."
-- Albert Einstein, letter to a friend, 1901
"I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education."
-- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820
"What's the point of vaccination if it doesn't protect you from the unvaccinated?"
-- Sandy Gottstein
"Who gets to decide what the greater good is and how many will be sacrificed to it?"
