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Hormone replacement therapy - Findings of women's health initiative trial need not alarm usershttp://bmj.com/cgi/content/full/325/7356/113
EditorialsHormone replacement therapyFindings of women's health initiative trial need not alarm users
Observational studies have suggested a major health benefit of postmenopausal
hormone replacement therapy, including reductions in coronary heart
disease, osteoporotic fractures, and colorectal cancer. Such studies
have also suggested an increased risk for breast cancer and possibly
stroke. Critics have said that the benefits, but not the risks, may
simply reflect a healthy user bias and have demanded randomised
trials. The women's health initiative is a randomised trial of these
health outcomes to assess risks and benefits of intervention
strategies in a postmenopausal population. The trial has shown harm
for cardiovascular diseases, including coronary heart disease (the
primary outcome) and stroke, although it showed benefits for hip
fractures and bowel cancer. The relative risks for invasive breast
cancer, coronary heart disease, and stroke were increased, although
the absolute risks were very small. The findings may not be the same
for types of hormone replacement therapy other than those used in
this trial, or for lower doses of the regimen that was used One treatment arm of the trial included over 16 000 postmenopausal women who were taking continuous combined oestrogen-progestogen hormone replacement therapy, using conjugated equine oestrogens 0.625 mg plus medroxyprogesterone acetate 2.5 mg daily, tested against placebo.1 This primary prevention study was due to run for 8.5 years but was halted at just over 5 years because the number of cases of breast cancer had reached a prespecified safety limit. For 10 000 women taking hormone replacement therapy each year, compared with those not taking it, there would be an additional eight cases of invasive breast cancer, seven heart attacks, eight strokes, and eight pulmonary embolisms. However, there would also be six fewer bowel cancers and five fewer hip fractures. Overall mortality was not increased with therapy. Survival of the human species over two million years implies that female sex
hormones by themselves are not dangerous to health. If harm is
established, we must therefore examine the types of substitutes that
we use and their means of delivery. The small increase in the number
of patients with breast cancer accords with previous population
studies,2 as are the increases in venous
thromboembolism and the decreases in fractures and in bowel cancer.
Given the biological effects of oestrogen on the cardiovascular
system, the lack of benefit on coronary heart disease is surprising Hormone replacement therapy regimens using different oestrogens and progestogens, and different routes of administration, may be similar in their effects on the breast, bowel, and skeleton. But the metabolic effects of different regimens are clearly different,6 and this is most likely to have an impact on their cardiovascular effects. Indeed, the women's health initiative trial also has an oestrogen-alone arm for women with hysterectomies, which has not been stopped. We need to see these findings to know whether the medroxyprogesterone acetate is causing the harm. It is most unhelpful that this point about different oestrogens and progestogens was not appreciated by the recent recommendations of the Committee for Safety of Medicines and the Medicines Control Agency,7 which were inappropriate with respect to cardiovascular disease. Particularly for coronary heart disease, the dose (and possibly type) of oestrogen and the type of progestogen may be crucial. Similar studies using different types of hormone replacement therapy than the one used in this trial must be carried out. Women who are currently taking continuous combined oestrogen-progestogen should not panic, as it is most unlikely to have caused considerable harm. Certainly the risk of breast cancer is not appreciably increased during the first four years, so women wishing to take this therapy for the short term relief of menopausal symptoms should be reassured. However, they need to discuss with their doctor whether they should shift to a different preparation, which could theoretically have a more beneficial effect on the cardiovascular system. There is no right or wrong hormone replacement therapy to use in the short term, but in the light of the findings of this trial the use of hormone replacement therapy regimens containing conjugated oestrogens 0.625 mg together with medroxyprogesterone acetate (at any dose) should be avoided in the long term. The findings of this trial may not apply to lower doses of conjugated equine oestrogens, given with or without other progestogens. The long term effects of alternative hormone replacement therapy preparations have not yet been tested in large randomised trials, and this must become a research priority. At present, long term hormone replacement therapy should be given only on an individual basis, depending on the needs and risk factors of the patient. Long term therapy could still be considered for prevention of osteoporosis, used as part of the management of women with particular cardiovascular risk factors, and used for better quality of life. We do not yet know the effects, if any, for the prevention of dementia, although preliminary evidence is encouraging. Women who are already taking long term hormone replacement therapy should be reviewed and counselled. If they need further treatment, consideration should be given to switching them to another form of hormone replacement therapy if they are taking a regimen of conjugated equine oestrogen and medroxyprogesterone acetate. For women starting hormone replacement therapy, we continue to recommend that
the starting dose of oestrogen is kept low in women over the age of
60. For example, this would be 1 mg for oral, or 50 µg for
transdermal, oestradiol 17 j.stevenson@ic.ac.uk, Endocrinology
and Metabolic Medicine, Faculty of Medicine, Imperial College, London W2 1NY
malcolmwhitehead@mrmenopause.com, Menopause Clinic, King's College Hospital,
London SE5 8RX
Footnotes JCS and MIW have been investigators in various clinical trials of hormone replacement therapy regimens. JCS is an investigator in the MRC women's hormones intervention secondary prevention (WHISP) trial. MIW is an investigator in the UK national trial of use of hormone replacement therapy in women with early breast cancer. They have attended meetings and lectured on hormone replacement therapy, sometimes with the support of various pharmaceutical companies.
Rapid Responses:Read all Rapid Responses
Other related articles in BMJ:
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 "A foolish faith in authority is the worst enemy of truth." -- Albert Einstein, letter to a friend, 1901 "I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education." -- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820 "What's the point of vaccination if it doesn't protect you from the unvaccinated?" -- Sandy Gottstein "Who gets to decide what the greater good is and how many will be sacrificed to it?" -- Sandy Gottstein |
a
point that is acknowledged by the authors of the study.
