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Cancer
Baby cord cells offer
leukaemia breakthrough
James Meek, science
correspondent
Tuesday July 9, 2002
The Guardian
A male nurse with leukaemia has been brought back from the brink of death by
blood from a newborn baby's umbilical cord which, in virtually all British
births, is thrown away as useless.
The extraordinary recovery of Stephen Knox, 31, the first time an adult
in Britain has been treated this way, is certain to lead to calls for more
publicly funded cord blood banks to be set up. At present there are only
two.
The usual last-ditch treatment for leukaemia sufferers is a transplant of
bone marrow, which makes blood cells. This involves destroying the patient's
existing bone marrow and replacing it with marrow from a family member or
compatible donor. Hundreds of patients still die because they cannot find a
match.
It has been known for some time that blood from newborn babies' umbilical
cords, normally discarded at birth, contains stem cells which could be an
alternative to bone marrow.
A handful of British children have been treated in this way but it had
been thought that adults could not. Even if matching cells could be found
from one cord, they would not be enough to repopulate the entire marrow.
Then Stephen Proctor, a consultant and leukaemia researcher at Newcastle
University, heard by chance of operations in Canada where doctors had mixed
matching and non-matching batches of cord cells together with remarkable
success. On February 22, at Newcastle's Royal Victoria Infirmary, Professor
Proctor's team injected a mixture of stem cells from the umbilical cords of
seven babies into Mr Knox, from Middleton-St-George, near Darlington, Co
Durham.
Mr Knox had been given a few months to live after chemotherapy had
failed.
One of the cords was a perfect match: the other six were not. But instead
of the body rejecting the unmatched cells, they appeared to act as boosters
for the tiny number of matched ones, and Mr Knox began to recover.
The amount of blood which can be taken from an umbilical cord is about
enough to fill a wine glass. But of that, only a tiny fraction - a few
hundred out of billions of cells - will be the kind of stem cells needed to
replace some six pounds of destroyed bone marrow.
To the astonishment of Prof Proctor, Mr Knox's white blood cell level was
up to adequate levels by five weeks.
"I wouldn't have believed that was possible," Prof Proctor said. "Stephen
is progressing much better than we thought he would and the transplant has
worked much better and more quickly than we expected. It's a really exciting
development and opens up huge possibilities. It has been carried out 23
times in the UK on children but never with an adult."
The two publicly funded cord blood banks in Britain - one in Newcastle,
the other in London - have too little money to collect and store the amount
of blood that would be needed for a comprehensive nationwide transplant
programme.
Private cord blood banks are available but expensive. The parents of the
first so-called "designer" baby to be born in Britain, genetically
pre-selected to be a tissue match for her brother, who had suffered from
leukaemia, stored her cord blood when she was born in case their son had a
relapse.
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